A5047494394- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Tracheal and airway disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Infectious Diseases and Tuberculosis
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- RNA regulation and disease
- Restless Legs Syndrome Research
- Full-Duplex Wireless Communications
- Polyomavirus and related diseases
- biodegradable polymer synthesis and properties
- Infectious Encephalopathies and Encephalitis
- Cognitive Functions and Memory
- Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Sinusitis and nasal conditions
- Cooperative Communication and Network Coding
- Osteomyelitis and Bone Disorders Research
- Respiratory and Cough-Related Research
- Autoimmune and Inflammatory Disorders
Hiroshima University
2019-2025
Hiroshima University Hospital
2013-2022
Aichi Medical University
2021
Hiroshima International University
2021
National Hospital Organization
2021
Nagoya University
2021
Kure Medical Center
2021
Hiroshima City Asa Citizens Hospital
2018-2021
Weight loss, a key indicator of malnutrition in amyotrophic lateral sclerosis (ALS) patients, negatively impacts patient prognosis. However, effective nutritional interventions have not been adequately established. Research ALS model mice has shown that L-arginine can prolong survival; however, no human intervention studies conducted. We conducted single-center, single-arm, prospective, open-label, and comparative trial to assess the safety tolerability hydrochloride patients. patients were...
Synthetic magnetic resonance imaging (MRI) is an innovative MRI technology that enables the acquisition of multiple quantitative values, including T1 and T2 proton density, myelin volume, in a single scan. Although usefulness measurement with synthetic has been reported for assessing several diseases, investigations patients stroke have not reported. We aimed to explore utility quantification using predicting outcomes acute ischemic stroke. Patients (n=101) premorbid modified Rankin Scale...
Abstract Background Both fragile X-associated tremor/ataxia syndrome (FXTAS) and late-onset neuronal intranuclear inclusion disease (NIID) show CGG/GGC trinucleotide repeat expansions. Differentiating these diseases are difficult because of the similarity in their clinical radiological features. It is unclear that skin biopsy can distinguish NIID from FXTAS. We performed a an FXTAS case with cognitive dysfunction peripheral neuropathy without tremor, which was initially suspected to be NIID....
Background and purpose Non-invasive, simple, repetitive swallowing evaluation is required to prevent aspiration pneumonia in neurological care. We investigated the usefulness of sound patients with amyotrophic lateral sclerosis (ALS) using our new electronic stethoscope artificial intelligence (AI) analysis tool. Methods studied ALS who provided written informed consent. used an stethoscope, placed a Bluetooth-enabled on upper end sternum, performed 3-mL water swallow three times, remotely...
High-density surface electromyography (HD-sEMG) has enabled non-invasive analysis of motor unit (MU) activity and recruitment, but its application to swallowing-related muscles is limited.
Abstract Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman diagnosed SLE undergoing immunosuppressive therapies, including azathioprine, presented cerebral cortical symptoms, lymphocytopenia, and vitamin B12 deficiency was subsequently PML. We evaluated cause disease activity PML, focusing on longitudinal...
Abstract Aspiration pneumonia is the leading cause of death in patients with Parkinson’s disease. The incidence silent aspiration high such owing to decreased pharyngeal and laryngeal sensation; thus, interventions for this condition may help prevent pneumonia. In single-arm, open-label study, we used a cervical percutaneous interferential current stimulation device activate sensory nerves. We evaluated its effectiveness Hoehn–Yahr stages 2–4 primary endpoint was proportion normal cough...
Parkinson's disease (PD) can lead to swallowing dysfunction, resulting in aspiration pneumonia. Among the types of disorders, a characteristic and serious problem associated with PD is silent due pharyngeal laryngeal hypoesthesia.This single-arm, open-label study aims evaluate effectiveness percutaneous neck interferential current sensory stimulation enhancing function patients PD. The efficacy safety will be investigated for diagnosed PD, based on Movement Disorder Society criteria,...
Colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is an adult-onset caused by mutations in CSF1R. The present study aimed to explore the broader genetic spectrum of CSF1R-related association with clinical and imaging features.Mutational analysis CSF1R was performed for 100 consecutive patients leukoencephalopathy. Sequence copy number variation (CNV) analyses were performed. genomic ranges deletions determined long-read sequencing. Ligand-dependent autophosphorylation...
Neuronal intranuclear inclusion disease (NIID) is a slowly progressive neurodegenerative disorder with wide range of clinical manifestations, including dementia and peripheral neuropathy.1 NIID pathologically characterized by eosinophilic hyaline inclusions found in the central nervous systems various organs, skin,1,2 which enables confirmation diagnosis skin biopsy.2 High-intensity signals along corticomedullary junction on diffusion-weighted imaging (DWI) bilateral leukoencephalopathy are...
Parkinson's disease (PD) presents with motor symptoms that hinder physical activity. This study aimed to thoroughly investigate swallowing dysfunction in patients PD using videofluoroscopy (VF) and the Movement Disorder Society (MDS)-Unified Rating Scale (UPDRS) sub-scores.
We present a case with non-convulsive status (NCSE) in which density spectrum array (DSA) illustrated "three little seizures." The conventional EEG was not useful. However, DSA revealed three seizures lasting for 30-40 seconds gradual decrease frequency, along the temporal frequency change. highlights usefulness of detecting NCSE, particularly cases where there is no typical rhythmic and periodic pattern.
Objective Prospective memory (PM) is an important social cognitive function in everyday life. PM one of the most affected domains multiple sclerosis (MS) patients. Gray matter (GM) atrophy and plaques have been attracting attention for various impairments MS This study aimed to clarify atrophic GM regions associated with deficits investigate relationship between plaques.
<title>Abstract</title> Weight loss, a key indicator of malnutrition in amyotrophic lateral sclerosis (ALS) patients, negatively impacts prognosis. However, effective nutritional interventions have not been adequately established. Previous research ALS model mice has shown that L-arginine can prolong survival, yet no human intervention studies conducted. This study aimed to assess the safety, tolerability, and efficacy hydrochloride patients. patients were administered 15 g/day for 90 days....
The study investigates end-of-life trajectories, focusing on the degree of oral intake function in older individuals with frailty aged over 90 years.
Parkinson's disease (PD) leads to various types of swallowing disorders. We investigated the effect cervical percutaneous interferential current stimulation on dysphagia. By conducting detailed qualitative and quantitative analysis videofluoroscopic examination, we aimed understand dysphagia in patients with PD investigate its effects function.Patients received for 20 min twice a week 8 weeks. In this exploratory study, evaluated aspiration/laryngeal penetration, oral cavity residue,...