A5075515448- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Skin Diseases and Diabetes
- Peripheral Neuropathies and Disorders
- Eosinophilic Disorders and Syndromes
- Marine Toxins and Detection Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Urticaria and Related Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone health and treatments
- Pneumonia and Respiratory Infections
- Otitis Media and Relapsing Polychondritis
- Psoriasis: Treatment and Pathogenesis
- Marine Sponges and Natural Products
- IgG4-Related and Inflammatory Diseases
- Chronic Lymphocytic Leukemia Research
- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- Polyomavirus and related diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Erythropoietin and Anemia Treatment
Hiroshima University Hospital
2019-2025
Miyoshi Kasei (Japan)
2024
ClassNK
2024
Hiroshima City Asa Citizens Hospital
2019
Taisho Pharmaceutical (Japan)
2010-2018
Hokkaido University
1998-2002
Kobe University
1992-2001
Washington University in St. Louis
1990
Abstract Objectives: Studies on the clinical features of undifferentiated peripheral spondyloarthritis (upSpA) are limited. This study explores sex-based manifestations upSpA and compares with rheumatoid arthritis (RA) under conditions low human leukocyte antigen B27 positivity in Japan. Methods: In this multicenter prospective observational study, physical laboratory findings from 29 cases (19 females, 10 males) were collected to investigate sex differences. Fourteen patients RA also...
Abstract To achieve the goal of a 50% reduction CO 2 emission in maritime industry by 2050, different systems and solutions were proposed researchers. Rigid wind sails, rotor suction wings, kites developed to contribute cleaner environment-friendly transportation reducing total fuel energy consumption. In present study, ship dynamics model KVLCC2 consisting hull, rudder, propeller, sailing system was built considering effects wave. Firstly, amount consumption both examined under directions...
Abstract Background Blood coagulation factor XIII (FXIII) promotes cross-linking between fibrin molecules at the final stage of blood cascade. However, its expression in cells or tissues and function, particularly subunit B (FXIII-B), remains controversial. Hemorrhagic FXIII deficiency following anti-interleukin-6 (IL-6) receptor antibody treatment has been reported patients with rheumatoid arthritis (RA). Patients receiving this biologics have reduced activity when compared to those treated...
ABSTRACT The direct causes of dermatomyositis, a common autoimmune disease, have not yet been accurately identified, but several studies linked this condition to various patient-associated and environmental factors, such as viral infections area residence. In the present report, we describe our experience with patient presenting anti-melanoma differentiation–associated gene 5 (MDA5) antibody-positive which developed after vaccination against coronavirus disease 2019 (COVID-19). This was...
Abstract Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman diagnosed SLE undergoing immunosuppressive therapies, including azathioprine, presented cerebral cortical symptoms, lymphocytopenia, and vitamin B12 deficiency was subsequently PML. We evaluated cause disease activity PML, focusing on longitudinal...
An efficient synthesis of the C10−C31 (BCDEF ring) portion pinnatoxin A has been achieved. The key step is a highly stereoselective construction dispiroketal (BCD system employing an intramolecular hetero-Michael reaction reversibly formed hemiketal alkoxide through use LiOMe.
This case report describes a 52-year-old immunocompromised man diagnosed with disseminated Mycobacterium abscessus complex (MABC) infection. The patient had history of malignant lymphoma and presented fever polyarthritis that lasted 3 weeks. Upon initial evaluation, blood synovial fluid cultures from the swollen joints were negative. Reactive arthritis or rheumatoid was suspected as cause inflammatory synovitis in multiple joints. Administration prednisolone followed by an interleukin-6...
There is evidence suggesting some role of mononuclear cells at the resorptive site in bone remodeling. The possibility was therefore postulated that these might provide signal for osteoclast formation. We examined effects human monocyte-conditioned medium (CM) on formation osteoclast-like from hemopoietic blast absence stromal and unfractionated presence cells. In both culture systems, cell induced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] or parathyroid hormone (PTH)-(1–34) significantly...
<b><i>Background:</i></b> TP0463518 is a novel hypoxia-inducible factor prolyl hydroxylase inhibitor developed to aid in the treatment of anemia associated with chronic kidney disease (CKD) and expected increase erythropoietin (EPO) derived from liver. Two phase I studies were conducted healthy volunteers (HV) CKD patients undergoing hemodialysis (i.e., HD patients) or those not dialysis ND patients). <b><i>Methods:</i></b> Pharmacokinetics,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes disease 2019 (COVID-19), utilizes the host receptor angiotensin-converting enzyme (ACE2) and auxiliary Neuropilin-1 (NRP1) to enter cells. NRP1 has another isoform, NRP2, whose function in COVID-19 seldom been reported. In addition, although patients with severe cases of often exhibit increased levels proinflammatory cytokines, relationship between these cytokines SARS-CoV-2 proliferation remains unknown. The aim this...
We purified a glutamyl endopeptidase that is major foliar in cucumber. The had molecular mass of 400 kDa, consisted four subunits 97 and was inactivated by SH-modifying reagents. Its optimum pH temperature were 8.0 30-37 degrees C, respectively. An internal amino acid sequence the highly homologous to partial unidentified proteins deduced from genetic information for Arabidopsis thaliana, soybean rice, but not sequences bacterial endopeptidases or animal proteases. Therefore, might be widely...
Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients LE.We consecutively registered diagnosed LE between January 2009 and October 2019, retrospectively compared their clinical characteristics based on whether they had good or treatment.A total 13 (17 episodes) were included. The median age 41 years, 12 female. A comparison groups...
An efficient method for the reconstruction of 9-dihydroerythromycin A macrolactone skeleton has been established. The key steps are oxidative cleavage at 11,12-position and after insertion an appropriate functionalized amino alcohol. Novel 15-membered macrolides, we named as "11a-azalides", were synthesized based on above methodology evaluated their antibacterial activity. Among them, (13R)-benzyloxymethyl-11a-azalide showed most potent Streptococcus pneumoniae activity, with improved...
Abstract Objectives This study aimed to quantify nailfold capillary (NFC) abnormalities in anti–melanoma differentiation–associated gene 5 (MDA5) -positive DM patients and evaluate the association with clinical parameters, including serum biomarkers. In addition, we clarify period leading remission of NFC during immunosuppressive treatment DM. Methods A prospective observational was conducted (n = 10) who first visited Hiroshima University Hospital were diagnosed or clinically amyopathic...
A new route to (+)-a-allokainic acid commencing with L-serine has been established, wherein the key step involves a C3-C4 bond formation simultaneous creation of C2, C3-trans and C3, C4-trans arrangement substituents by Rh2(0Ac)4-catalyzed C-H insertion reaction adiazoacetoacetamide tethered (S)-4-(3-butenyl)-2,2-dimethyl-1,3-oxazolidine system.Taher's conlputational model confirms observed diastereomer preference.With advent dirhodium(l1) carboxylate catalysts, intramolecular reactions...
Nailfold capillary abnormalities are typically observed in patients with systemic sclerosis and also often found polymyositis (PM) dermatomyositis (DM). some PM/DM were to improve immunosuppressant treatment. However, the short-term changes nailfold capillaries their associations disease activity have not been established yet. Additionally, there no reports on whether can change during progression of malignant tumours. A man his 60s anti-transcriptional intermediate factor 1γ (anti-TIF-1γ)...
Multiple external root resorption (MERR) has been reported in systemic sclerosis (SSc) patients Japan and Spain. To establish whether MERR is a new manifestation, we investigated the prevalence of oral manifestations to be associated with SSc. Root was detected by dental X-rays, panoramagraphy or cone beam computed tomography (CBCT). The examined rheumatologists dentists, respectively. Autoantibodies were using laboratory tests. four out 41 (9.8%) who participated present study. digital...