A5025540458- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- IgG4-Related and Inflammatory Diseases
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Salivary Gland Disorders and Functions
- Abdominal vascular conditions and treatments
- Tuberculosis Research and Epidemiology
- Neuroendocrine Tumor Research Advances
- Inflammasome and immune disorders
- Skin Diseases and Diabetes
- Dermatological and COVID-19 studies
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Urticaria and Related Conditions
- Mycobacterium research and diagnosis
- Kawasaki Disease and Coronary Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Otitis Media and Relapsing Polychondritis
- Cancer Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Autoimmune and Inflammatory Disorders Research
Hiroshima University Hospital
2022-2025
St. Luke's International Hospital
2020-2023
ABSTRACT The direct causes of dermatomyositis, a common autoimmune disease, have not yet been accurately identified, but several studies linked this condition to various patient-associated and environmental factors, such as viral infections area residence. In the present report, we describe our experience with patient presenting anti-melanoma differentiation–associated gene 5 (MDA5) antibody-positive which developed after vaccination against coronavirus disease 2019 (COVID-19). This was...
This case report describes a 52-year-old immunocompromised man diagnosed with disseminated Mycobacterium abscessus complex (MABC) infection. The patient had history of malignant lymphoma and presented fever polyarthritis that lasted 3 weeks. Upon initial evaluation, blood synovial fluid cultures from the swollen joints were negative. Reactive arthritis or rheumatoid was suspected as cause inflammatory synovitis in multiple joints. Administration prednisolone followed by an interleukin-6...
To identify risk factors for relapse after methotrexate (MTX) dose reduction in rheumatoid arthritis (RA) patients receiving golimumab (GLM)/MTX combination therapy.Data on RA ≥20 years old GLM (50 mg) + MTX ≥6 months were retrospectively collected. was defined as a of ≥12 mg from the total within 12 weeks maximum (≥1 mg/wk average). Relapse Disease Activity Score 28 joints using C-reactive protein level (DAS28-CRP) score ≥3.2 or sustained (≥ twice) increase ≥0.6 baseline.A 304 eligible...
ABSTRACT Since its approval for the management of systemic lupus erythematosus (SLE), belimumab has been widely used. However, pregnancy safety profile underinvestigated. We present outcomes two cases early placental exposure to and summarise in previous reports regarding belimumab. Case 1 describes a 27-year-old woman with an 18-year history SLE nephritis class III. introduced 19 months prior conception control her proteinuria discontinued use at 5 weeks days gestation. Her activity was...
Abstract We aimed to clarify the long-term safety and efficacy of rituximab (RTX) as a remission induction therapy following severe relapse in patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). retrospectively collected data severely relapsed AAV from Japanese multicentre cohort. The primary exposure was RTX use; outcome complete (CR) proportions at week 24. Baseline characteristics were compared between non-RTX groups. performed multivariate logistic...
To clarify seasonal and other environmental effects on the onset of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).We enrolled patients with new-onset eosinophilic granulomatosis polyangiitis (EGPA), microscopic (MPA), (GPA) registered in database a Japanese multicenter cohort study. We investigated relationship between factors clinical characteristics. Seasons were divided into 4 (spring, summer, autumn, winter), differences AAV analyzed using Pearson chi-square...
Background: Currently it is hypothesized that many systemic autoimmune diseases occur due to environmental risk factors in addition genetic factors. Anti-Neutrophil Cytoplasmic Antibody (ANCA) mainly associated with three disease including granulomatosis polyangiitis (GPA), microscopic (MPA), eosinophilic (EGPA). It known ANCA can be positive before clinical symptoms patients diagnosis of GPA and titers rise manifestations appear. However, prevalence among general population not well known....
<h3>Background</h3> Rituximab (RTX) is widely used in both remission induction and maintenance therapy for the new-onset ANCA-associated vasculitis (AAV)[1]. However, few studies have reported efficacy safety of RTX against relapsed AAV, especially elderly patients. <h3>Objectives</h3> To clarify effectiveness as a after relapse AAV. <h3>Methods</h3> We retrospectively extracted (≥65 years) patients who granulomatosis with polyangiitis or microscopic received from J-CANVAS, Japanese...
Background: Thyroid disorders are known as common comorbidities of rheumatic diseases(RD) [1]. However, data regarding prevalence hyperthyroidism with treatment indication in RD patients limited. Objectives: This study aims to reveal and compare the frequency newly developed between healthy controls (HC), identify risk factors whose thyroid function should be followed up carefully. Methods: We retrospectively reviewed charts HC who had stimulating hormone (TSH) measured at least once 2004...
Background: IgG4-Related Disease (IgG4RD) is known to cause multiple organ lesions with infiltration of IgG4-positive plasma cells, and patients often have relapses tapering treatments despite an initial good response glucocorticoids therapy. Mizoribine (MZR) immunosuppressant working as inhibitor purine synthesis, which mechanism action similar mycophenolate mofetil. Data regarding the efficacy safety MZR on IgG4RD limited although some previous case reports 1 showed effectiveness for...
Background: It is well known that rheumatoid arthritis (RA) occurs due to environmental risk factors in addition genetic factors. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) are strongly associated with RA, these biomarkers could turn be positive before development of clinical symptoms. While smoking, particularly Brinkman index (BI) as a for RA ACPA positivity, it still unclear whether smoking intensity or duration contribute more RF ACPA. Objectives: This...
<h3>Objective</h3> Belimumab in combination with mycophenolate mofetil has been proven to be effective for treating systemic lupus erythematosus (SLE) several randomized controlled trials. Calcineurin inhibitors, tacrolimus, and voclosporine are also useful controlling the activity of nephritis. However, safety effectiveness belimumab-calcineurin inhibitor therapy not addressed. Therefore, we conducted a single-center retrospective study analyze efficacy profile belimumab-tacrolimus (B-T)...
Background: Coronary periarteritis is one of the clinical manifestations IgG4-related disease. It can cause serious conditions such as angina and ruptured aneurysms. Therefore, it important to recognize radiological characteristics, which was little known. Objectives: We report four patients with coronary a systematic literature review. Methods: identified at St. Luke’s International Hospital in Tokyo, Japan from 2014 2020. A review conducted for English articles on cases full text or...