A5060484739- Vasculitis and related conditions
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Medical Imaging Techniques and Applications
- Cell Adhesion Molecules Research
- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- Neuroendocrine Tumor Research Advances
- Sarcoidosis and Beryllium Toxicity Research
- Bladder and Urothelial Cancer Treatments
- Testicular diseases and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urinary and Genital Oncology Studies
- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Diabetes Treatment and Management
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- S100 Proteins and Annexins
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- IgG4-Related and Inflammatory Diseases
- Chemotherapy-induced organ toxicity mitigation
- Renal Diseases and Glomerulopathies
Kyoto Katsura Hospital
2022-2025
Osaka University of Pharmaceutical Sciences
2017-2025
Kansai Medical University
2025
Kanagawa Cardiovascular and Respiratory Center
2024
Kyoto University
2012-2023
National Cerebral and Cardiovascular Center
2016-2018
Kitano Hospital
2016
Tokyo Institute of Technology
2015
Naga Municipal Hospital
2005-2007
Gifu University
1994-2007
Although 4-borono-l-phenylalanine (4-BPA) is currently the only marketed agent available for boron neutron capture therapy (BNCT), its low water solubility raises concerns. In this study, we synthesized 3-borono-l-phenylalanine (3-BPA), a positional isomer of 4-BPA, with improved solubility. We further evaluated physicochemical properties, tumor accumulation, and biodistribution. The 3-BPA was 125 g/L, which more than 100 times higher that 4-BPA. Due to high solubility, prepared...
Rituximab (RTX) has been reported to effectively maintain remission in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). In this multicenter study involving 57 patients who achieved after 24 weeks, we evaluated the effectiveness of RTX maintaining with AAV. Patients were divided into three groups based on administration: continuous, induction phase-only, and maintenance phase-only groups. The continuous group had a rate 48 weeks treatment compared (100% vs. 88.2%, p = 0.29)....
Cytomegalovirus (CMV) reactivation during immunosuppressive therapy poses a risk of severe infections. This study aimed to investigate the factors CMV in patients with microscopic polyangiitis and granulomatosis using nationwide cohort Japan. retrospective used data from Japan Collaborative Registry anti-neutrophil cytoplasmic antibody-associated vasculitis. The outcome was as up 48 weeks after treatment initiation. We explored for by comparing two groups. Of 454 patients, occurred 89...
Glucagon-like peptide-1 receptor (GLP-1R) is an emerging critical target for the diagnosis and treatment of various diseases. Radiolabeled exendin-4 (Ex-4), a GLP-1R agonist, has been widely used as imaging probe. However, its potential to induce hypoglycemia, especially in patients with insulinoma, limits applicability. This study evaluated whether Ex-D3, Glu3Asp substitution Ex-4 higher internalization rate, could enhance efficacy while reducing hypoglycemic effects. We synthesized...
Background/Objectives: Integrin αVβ3 plays a crucial role in tumor angiogenesis and cancer progression, making it key target for radiolabeled probes used imaging therapy. A previously developed probe, [125I]bcRGD, exhibited high selectivity but limited accumulation due to rapid blood clearance. This study aimed address this issue through two strategies: (1) conjugating albumin-binding molecules enhance systemic circulation (2) dimerizing RGD peptides improve binding affinity via multivalency...
Background/Objectives: The kinase p38α, a member of the mitogen-activated protein (MAPK) family, is activated by external stimuli and plays crucial role in inflammation, tumor growth, metabolic disorders. In particular, p38α involved thermogenesis metabolism glucose brown adipose tissue (BAT), it contributes to suppression obesity diabetes. noninvasive imaging could help elucidate diverse pathological processes, including inflammatory conditions. This study aimed develop evaluate novel...
In elderly hemodialysis (HD) patients, the risk of medication-related problems is particularly high. Thus, certain medications should generally not be prescribed to those patients. The Beers criteria for potentially inappropriate (PIMs) have been publicized. Still, with regard HD prevalence and factors prescription PIMs are unknown. This was a cross-sectional study data from Japan Dialysis Outcomes Practice Patterns Study (2002–08). Patients were included if they 65 years old or older...
Cardiovascular complications are the leading cause of death in autosomal dominant polycystic kidney disease (ADPKD), and intracranial aneurysm (ICA) causing subarachnoid hemorrhage is among most serious complications. The diagnostic therapeutic strategies for ICAs ADPKD have not been fully established. We here generated induced pluripotent stem cells (iPSCs) from seven patients, including four with ICAs. vascular differentiated ADPKD-iPSCs showed altered Ca(2+) entry gene expression profiles...
To investigate the association between decreased serum IgG levels caused by remission-induction immunosuppressive therapy of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and development severe infections.We conducted a retrospective cohort study patients with new-onset or relapsing AAV enrolled in J-CANVAS registry, which was established at 24 referral sites Japan. The minimum up to weeks incidence infection 48 after treatment initiation were evaluated. After multiple...
Background: Acetaminophen (APAP) is frequently used for analgesia and considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) the kidneys. However, there little epidemiological evidence of association between APAP acute kidney injury (AKI). Objectives: To examine AKI using self-controlled case series (SCCS) method, which a novel strategy to control between-person confounders by comparing risk reference periods in each patient. Methods: We performed SCCS 1,871 patients (39.9%...
Abstract Background This study investigated the characteristics of hypertrophic pachymeningitis (HP) in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), using information from a multicenter Japan. Methods We analyzed clinical 663 Asian patients with AAV (total AAV), including 558 newly diagnosed and 105 relapsed AAV. Clinical findings were compared between without HP. To elucidate relevant manifestations for HP development, multivariable logistic regression analyses...
Cancer is a major cause of death in patients undergoing haemodialysis. However, information about the actual clinical practice chemotherapy for with cancer haemodialysis lacking. We conducted nationwide survey using questionnaires on such patients.The included who were subsequently diagnosed 20 hospitals Japan from January 2010 to December 2012. reviewed their data, including at following primary sites: kidney, colorectum, stomach, lung, liver, bladder, pancreas and breast. The consisted...
Since membrane type-1 matrix metalloproteinase (MT1-MMP) plays pivotal roles in tumor progression and metastasis holds great promise as an early biomarker for malignant tumors, a method of evaluating MT1-MMP expression levels would be valuable molecular biological clinical studies. Although we have previously developed (99m) Tc-labeled anti-MT1-MMP monoclonal IgG ((99m) Tc-MT1-mAb) imaging probe by nuclear medical techniques this purpose, slow pharmacokinetics were problem due to its large...
Positron emission tomography with 15O-labeled gases (15O-PET) is important for in vivo measurement of cerebral oxygen metabolism both clinical and basic settings. However, there are currently no reports concerning 15O-PET mice. Here, we developed an method applicable to mice spontaneous respiration 15O-gas without a tracheotomy catheter. Sequential was also performed mouse model chronic hypoperfusion bilateral common carotid artery stenosis (BCAS) induced by placement microcoils. isoflurane...
Membrane type-1 matrix metalloproteinase (MT1-MMP) is a protease activating MMP-2 that mediates cleavage of extracellular components and plays pivotal roles in tumor migration, invasion metastasis. Because vivo noninvasive imaging MT1-MMP would be useful for diagnosis, we developed novel near-infrared (NIR) fluorescence probe can activated following interaction with vivo. MT1-hIC7L an activatable comprised anti-MT1-MMP monoclonal antibodies conjugated to self-assembling polymer micelles...
Since the therapeutic effect of boron neutron capture therapy is influenced by intracellular distribution profile boronoagents containing 10B atoms, it necessary to establish a method that can determine boronoagents. We aimed develop small molecule-based fluorescence sensor changes its properties upon complexation with boronic acid moiety boronoagent. Thus, we designed 2-(2-pyridyl)phenol derivative PPN-1 introducing N,O ligand substructure into zinc probe excellent properties. To...
Boron neutron capture therapy (BNCT) is an attractive approach to treating cancers. Currently, only one 10B-labeled boronoagent (Borofalan, BPA) has been approved for clinical BNCT in Japan, and methods predicting measuring efficacy must be established support the development of next-generation 10B-boronoagents. Fluorescence sensors targeting boronic acids can achieve this because amount localization 10B tumor tissues directly determine efficacy; however, current are nonoptimal given their...
As matrix metalloproteinases (MMPs), especially MMP-9 and MMP-12 are involved in the pathological processes associated with chronic obstructive pulmonary disease (COPD), we developed a novel radiofluorinated probe, 18F-IPFP, for MMPs-targeted positron emission tomography (PET). 18F-IPFP was designed by iodination of MMP inhibitor to enhance affinity, labelled compact prosthetic agent, 4-nitrophenyl 2-18F-fluoropropionate (18F-NFP). result, IPFP demonstrated highest affinity toward (IC50 =...
Abstract Objectives To evaluate the effectiveness and safety of two different intravenous methylprednisolone (IVMP) pulse doses in patients with severe microscopic polyangiitis (MPA) granulomatosis (GPA). Methods We emulated a target trial using observational data from nationwide registry Japan. Patients glomerulonephritis or diffuse alveolar haemorrhage were selected pseudo-randomized into three groups propensity score-based overlap weighting as follows: non-IVMP, IVMP 0.5 g/day 1.0 g/day....
Membrane type-1 matrix metalloproteinase (MT1-MMP) plays pivotal roles in tumor progression and metastasis, holds great promise as an early biomarker for malignant tumors. Therefore, the ability to evaluate MT1-MMP expression could be valuable molecular biological clinical studies. For this purpose, we aimed develop short peptide-based nuclear probes because of their facile radiosynthesis, chemically uniform structures, high specific activity, compared antibody-based probes, which allow them...
The amount and localization of boron-10 atoms delivered into tumor cells determines the therapeutic effect boron neutron capture therapy (BNCT) and, consequently, efforts have been directed to develop fluorescence sensors detect intracellular boronic acid compounds. Currently, these are blue-emitting hence impracticable for co-staining with nucleus staining reagents, such as DAPI Hoechst 33342. Here, we designed synthesized a novel sensor, BS-631, that emits maximum emission wavelength 631...