A5058482393- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Urticaria and Related Conditions
- Multiple Myeloma Research and Treatments
- Peripheral Nerve Disorders
- Lysosomal Storage Disorders Research
- IL-33, ST2, and ILC Pathways
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Streptococcal Infections and Treatments
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
- Sepsis Diagnosis and Treatment
- T-cell and B-cell Immunology
- Veterinary Equine Medical Research
- Musculoskeletal synovial abnormalities and treatments
- Nitric Oxide and Endothelin Effects
Kyoto Prefectural University of Medicine
1998-2024
Kindai University
2021
Kitasato University
2021
Higashi Osaka City General Hospital
2021
Osaka Women's and Children's Hospital
2018
Healthcare-associated infections after pediatric cardiac surgery are significant causes of morbidity and mortality. We aimed to identify the risk factors for occurrence healthcare-associated surgery.Retrospective, single-center observational study.PICU at a tertiary children's hospital.Consecutive patients less than or equal 18 years old admitted PICU surgery, between January 2013 December 2015.None.All data were retrospectively collected from medical records patients. assessed first during...
Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). The heterogeneity ILDs reflects differences in pathogenesis among diseases. This study aimed to clarify the characteristics CTD-ILDs via detailed analysis bronchoalveolar lavage fluid (BALF) and blood immune cells. BALF samples were collected from 39 Japanese patients with newly diagnosed ILD: five Sjögren's syndrome (SS), eight dermatomyositis (DM), six rheumatoid arthritis (RA), systemic...
Abstract Objectives To evaluate the effectiveness and safety of two different intravenous methylprednisolone (IVMP) pulse doses in patients with severe microscopic polyangiitis (MPA) granulomatosis (GPA). Methods We emulated a target trial using observational data from nationwide registry Japan. Patients glomerulonephritis or diffuse alveolar haemorrhage were selected pseudo-randomized into three groups propensity score-based overlap weighting as follows: non-IVMP, IVMP 0.5 g/day 1.0 g/day....
Patients with glucocorticoid-induced osteoporosis (GIOP) are at very high risk of fracture, and patients severe GIOP often experience fractures during treatment bisphosphonates. Teriparatide (TPTD) is the only currently available anabolic agent expected to be effective for GIOP. Once-weekly TPTD decreased bone resorption marker primary different from daily TPTD, but it has not yet been tested GIOP.To evaluate efficacy once-weekly inadequate response bisphosphonates.Patients collagen diseases...
ABSTRACT Objectives To identify the optimal dose of intravenous cyclophosphamide (IVCY) for induction therapy anti-neutrophil cytoplasmic antibody-associated vasculitis. Methods We retrospectively assessed patients with vasculitis who received IVCY every 2–3 weeks during remission phase. The associations infection-free survival and relapse-free were analysed using a Cox regression model. compared in three categories: very low-dose (VLD), (LD), conventional (CD) (<7.5 mg/kg, 7.5–12.5...
Belimumab is a therapeutic medication that inhibits the B-cell-activating factor (BAFF) used for systemic lupus erythematosus (SLE); however, response sometimes varies among individuals, even when patients are stratified based on general clinical characteristics. Therefore, we focused immunological phenotypic changes with belimumab, investigated their association subsequent courses, and sought to identify relevant indicators stratify who would benefit from belimumab. We assessed in B T cell...
To determine whether patients with polymyalgia rheumatica (PMR) are more susceptible to glucocorticoid-induced adrenal insufficiency, one of the barriers glucocorticoid tapering strategies, compared rheumatoid arthritis (RA).This cross-sectional study included PMR and RA who underwent adrenocorticotropic hormone (ACTH) tests assess function. The eligibility criteria were as follows: previous use prednisolone (PSL) ≥ 5 mg/day, PSL for six consecutive months before ACTH test, current at mg/day...
We show that salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3'-O-benzylated analogs inhibit human lysosomal at submicromolar levels. Simple structure-activity relationship studies reveal salacinol side-chain stereochemistry significantly influences binding to GH31 α-glucosidases.
<h3>Background</h3> Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a serious complication and an important prognostic factor of various autoimmune diseases. Many cell types both innate adaptive immune systems are implicated in the pathogenesis fibrotic injury. The presentation clinical course CTD-ILD diverse, heterogeneity reflects differences underlying pathogenic mechanisms. <h3>Objectives</h3> objective this study to reveal different characteristics cells...
The measurement of various body dimensions horses plays a significant role in quality improvement, genetic breeding, health, and soundness. There has been advancement the technology for acquiring stereoscopic images with three-dimensional (3D) scanner. This study aimed to validate accuracy measurements obtained from taken 3D We manually took following 8 riding horses: height at withers, back, croup, chest depth, width chest, waist, girth circumference, cannon length. Using versatile...
<h3>Background</h3> Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a severe complication of rheumatic and musculoskeletal diseases, e.g. rheumatoid arthritis (RA), dermatomyositis (DM), systemic sclerosis (SSc) so on. CTD-ILD heterogeneous syndrome driven by different diseases cell types. This complexity provides challenging field for elucidating the mechanism disease. Although some patients with develop progressive fibrosing (PF-ILD) like as other ILD despite...