Yoshiyuki Shimizu

ORCID: 0000-0003-4378-4899
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About
Contact & Profiles
Research Areas
  • Granular flow and fluidized beds
  • Tunneling and Rock Mechanics
  • Central Venous Catheters and Hemodialysis
  • Methane Hydrates and Related Phenomena
  • Neonatal Respiratory Health Research
  • Advancements in Semiconductor Devices and Circuit Design
  • Clinical Nutrition and Gastroenterology
  • Fluid Dynamics Simulations and Interactions
  • Respiratory Support and Mechanisms
  • Drilling and Well Engineering
  • Biochemical Analysis and Sensing Techniques
  • Hemodynamic Monitoring and Therapy
  • Regulation of Appetite and Obesity
  • Grouting, Rheology, and Soil Mechanics
  • Cardiac Arrest and Resuscitation
  • Eosinophilic Esophagitis
  • Geotechnical Engineering and Soil Mechanics
  • Cardiac Imaging and Diagnostics
  • Congenital Diaphragmatic Hernia Studies
  • Acute Ischemic Stroke Management
  • Geotechnical Engineering and Underground Structures
  • Metabolism and Genetic Disorders
  • Emergency and Acute Care Studies
  • dental development and anomalies
  • Radio Frequency Integrated Circuit Design

Tokai University
2006-2025

Shimizu (Japan)
1997-2025

The University of Tokyo
2024-2025

Osaka Women's and Children's Hospital
2017-2025

Shizuoka University
2023

Kyoto University
2000-2021

Hamamatsu Photonics (United Kingdom)
2019-2021

Hokuriku University
2021

Hamamatsu Photonics (Japan)
2011-2020

Dokkyo University
2019-2020

Despite its long history, the central effects of progressive depletion vitamin A in adult mice has not been previously described. An examination vitamin-deprived animals revealed a and ultimately profound impairment hippocampal CA1 long-term potentiation virtual abolishment depression. Importantly, these losses are fully reversible by dietary replenishment vivo or direct application all trans -retinoic acid to acute slices. We find retinoid responsive transgenes be highly active hippocampus,...

10.1073/pnas.191369798 article EN Proceedings of the National Academy of Sciences 2001-09-11

A numerical analysis using the 3D distinct element method (DEM) is conducted in order to examine performance of screw conveyors. In particular, simulation horizontal and vertical types studied. The results are compared with previous work empirical equations. As a result, it determined that this sufficiently well developed useful analyze

10.1061/(asce)0733-9399(2001)127:9(864) article EN Journal of Engineering Mechanics 2001-09-01

In addition to NS3 protease, the NS4A protein is required for efficient cleavage of nonstructural region hepatitis C virus polyprotein. To investigate function and sequence enhancement protease activity, we developed an in vitro assay system consisting three purified viral elements: (i) a recombinant which was expressed Escherichia coli as maltose-binding protein-NS3 fusion (MBP-NS3), (ii) synthetic fragments, (iii) peptide substrate mimics NS5A/5B junction. We showed that activity MBP-NS3...

10.1128/jvi.70.1.127-132.1996 article EN Journal of Virology 1996-01-01

Polymetallic nodules and REE-rich mud under the seabed of 5500–5700 m water depth around Minamitorishima island are promising attractive for exploration development. Following our previous research, numerical analysis was used to investigate unsteady flow characteristics lifting performance a commercial production system using an air-lift pump hybrid lifting, both polymetallic mud. Gas–liquid–solid three-phase gas–liquid two-phase in were analyzed one-dimensional drift–flux model. First,...

10.3390/jmse13020267 article EN cc-by Journal of Marine Science and Engineering 2025-01-31

Healthcare-associated infections after pediatric cardiac surgery are significant causes of morbidity and mortality. We aimed to identify the risk factors for occurrence healthcare-associated surgery.Retrospective, single-center observational study.PICU at a tertiary children's hospital.Consecutive patients less than or equal 18 years old admitted PICU surgery, between January 2013 December 2015.None.All data were retrospectively collected from medical records patients. assessed first during...

10.1097/pcc.0000000000001445 article EN Pediatric Critical Care Medicine 2018-01-10

The levels of peripheral‐blood, naturally occurring aliphatic polyamines, such as putrescine, spermidine, and spermine, from 21 bronchial asthmatic patients (11 atopics 10 nonatopics) were measured by postcolumn derivatization high‐performance liquid chromatography analysis. None the patients, except 44‐year‐old woman in case report below, given prednisolone, they instructed to take only regular medication during tests. Blood was drawn a fasting state, polyamine compared between times when...

10.1111/j.1398-9995.1992.tb02388.x article EN Allergy 1992-12-01

This study evaluated whether the dynamic needle tip positioning technique increased success rate of ultrasound-guided peripheral venous catheterization in pediatric patients with a small-diameter vein compared static technique.Randomized controlled study.Single institution, Osaka Women's and Children's Hospital.The population included 60 less than 2 years old who required PICU.Patients were randomly divided into (n = 30) or group 30). Each received without positioning, respectively. The...

10.1097/pcc.0000000000002034 article EN Pediatric Critical Care Medicine 2019-06-22

Although open chest management optimizes hemodynamics after cardiac surgery, it increases postoperative infections and leads to increased mortality. Despite the importance of antibiotic prophylaxis during management, no specific recommendations exist. We aimed compare occurrence rates bloodstream infection surgical site between different prophylactic regimens for pediatric surgery.Retrospective, single-center, observational study.PICU at a tertiary children's hospital.Consecutive patients...

10.1097/pcc.0000000000001995 article EN Pediatric Critical Care Medicine 2019-05-16

The withdrawal response elicited by a nociceptive stimulus, i.e., evoked pain measure, is commonly used as an efficacy endpoint in neuropathic animal models. It, however, has several limitations, which highlight the importance of examining spontaneous pain. present study describes automated method for measuring behaviour rat model caused chronic constriction injury (CCI) sciatic nerve.After CCI surgery, small magnet was implanted into operated limb. placed test chamber that surrounded wire...

10.1002/j.1532-2149.2012.00142.x article EN European Journal of Pain 2012-03-27

Intestinal ischemia-reperfusion (I/R) injury plays an important role in the pathogenesis of systemic inflammation and multiple-organ failure. We studied whether glutamine, primary fuel small intestine, prevents intestinal mucosal damage after I/R rats.Rats were randomly divided into 4 groups: a sham-standard amino acid (SAA) group (n = 8); sham-glutamine (Gln) I/R-SAA 10); I/R-Gln 9). Alanyl-glutamine solution was produced by replacing 36% total nitrogen with Gln. The superior mesenteric...

10.1177/0148607103027002110 article EN Journal of Parenteral and Enteral Nutrition 2003-03-01

Purpose Cognitive processing generally deteriorates as people age. Recent neuroimaging studies have shown that the prefrontal cortex (PFC) is involved in human-specific behavior, such preparing for future actions and prospective memory; hence, PFC may be voluntarily activated even during "resting" condition precedes task execution. The purpose of present study was to investigate changes voluntary pre-task activation a result aging using paradigm includes longer intertrial interval (e.g., 30...

10.1371/journal.pone.0098779 article EN cc-by PLoS ONE 2014-06-04
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