A5086033120- Asthma and respiratory diseases
- Mast cells and histamine
- Polyamine Metabolism and Applications
- Respiratory and Cough-Related Research
- Eosinophilic Disorders and Syndromes
- Drug-Induced Adverse Reactions
- Allergic Rhinitis and Sensitization
- Inflammatory mediators and NSAID effects
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Receptor Mechanisms and Signaling
- Click Chemistry and Applications
- Protein Kinase Regulation and GTPase Signaling
- Glycosylation and Glycoproteins Research
- Food Allergy and Anaphylaxis Research
- Chemical Synthesis and Analysis
- Eosinophilic Esophagitis
- Biotin and Related Studies
- Inhalation and Respiratory Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Amino Acid Enzymes and Metabolism
- bioluminescence and chemiluminescence research
- Cell Adhesion Molecules Research
- Metabolism and Genetic Disorders
- Neuropeptides and Animal Physiology
Takara (Japan)
1996-2023
Sumitomo Chemical (Japan)
1996-2023
Osaka University
1993-2010
Institute for Asthma and Allergy
2005
Showa General Hospital
2003-2004
Akita University
2000-2002
Mitsubishi Group (Japan)
2002
Gunma University
1991-2000
Kyoto University
1998-2000
Hirosaki University
1998-2000
Extracellular matrix-destructive enzymes, like matrix metalloproteinases (MMP), have been recognized in the process of inflammation and tissue remodeling repair. The affected tissues often contain markedly increased numbers mast cells. Although cells are capable activating latent collagenase proMMP, it has so far unknown whether human themselves produce secrete MMP9. In this study, MMP9 production by cord blood-derived cultured HMC-1 was examined reverse-transcriptase PCR, gelatin zymography...
The levels of peripheral‐blood, naturally occurring aliphatic polyamines, such as putrescine, spermidine, and spermine, from 21 bronchial asthmatic patients (11 atopics 10 nonatopics) were measured by postcolumn derivatization high‐performance liquid chromatography analysis. None the patients, except 44‐year‐old woman in case report below, given prednisolone, they instructed to take only regular medication during tests. Blood was drawn a fasting state, polyamine compared between times when...
Clinically apparent panniculitis is rare in dermatomyositis. The common histopathological findings are infiltration of lymphocytes, epithelioid cells and plasma the fat lobules, along with varying degrees degeneration fibrosis. We report a 65-year-old woman dermatomyositis who developed characteristic histological change known as membranocystic lesion. Although this has been observed various diseases affecting subcutaneous tissue, it rarely reported Dermatomyositis should be included showing
Summary Background The mtist cell is one of the important cells In pathogenesis allergic disorders. However, isolating human mast a laborious procedure. Recently, cultured raised from umbilical cord blood have become available. It necessary to examine whether these are useful in investigating role diseases. Objective phenotype depends on their anatomical sites. To which phetiotype most closely resemble, ability release was investigated. Methods were presence stem factor and interIeukin‐6....
It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis. EDN concentrations the urine were measured by enzyme-linked immunosorbent assay, and number eosinophils peripheral blood was counted 30 patients with The severity dermatitis graded on criteria proposed Rajka Langeland. disease activity assessed each patient a visual analogue scale (VAS). Urinary showed significant...
<i>Background:</i> It has been reported that the number of mast cells was significantly greater in malignant breast carcinomas than benign lesions. This due to tryptase-containing while tryptase, chymase-containing had no effect. However, analysis and lesions based on their histological findings remains be elucidated. <i>Methods:</i> Using immunohistochemical methods morphological examinations were undertaken tissues from 51 patients (30 benign, 21 malignant), which...
It is well known that aspirin-exacerbated respiratory disease (AERD) more common in women than men, however, whether gene polymorphisms of the thromboxane A2 receptor (TBXA2R) and chemoattractant receptor-homologous molecules expressed on Th2 cells (CRTH2) are associated with susceptibility AERD remains unknown. In this study, we examined a Japanese population. DNA specimens were obtained from following three groups: 96 patients AERD, 500 aspirin-tolerant asthma (ATA) 100 normal controls....
Background Accumulating data indicates that pholcodine (PHO)-consuming countries have higher sero-prevalences of immunoglobulin E (IgE)-antibodies to PHO and suxamethonium (SUX) increased frequencies IgE-mediated anaphylaxis neuromuscular blocking agents (NMBAs) than nonconsuming. Withdrawing PHO-containing cough syrups resulted in a significant decrease cases with Scandinavia. Nevertheless, the European Medicines Agency 2011 advised continue unrestricted use throughout Union. Objective To...
An increase in mast cell number at sites of inflamed tissues has been observed. However, the expression CXC chemokine receptors on human cells is poorly understood.Cultured were raised from umbilical cord blood presence stem factor and interleukin-6 (IL-6). The surface was analyzed by flow cytometry that mRNA examined method reverse transcriptase-polymerase chain reaction (RT-PCR). As functional assays for receptors, migration a microchemotaxis assay changes cytosolic free intracellular...
Uptake and transformation of 14C-labeled metabolites from several pesticides, 3-methyl-4-nitrophenol (1), 3,5-dichloroaniline (2), 3-phenoxybenzoic acid (3), (R,S)-2-(4-chlorophenyl)-3-methylbutanoic (4), (1RS)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic (5), were examined by using duckweed (Lemna gibba) in Hoagland's medium. More uptake into the exposure water at pH 7.0 was observed for non-ionized 1 2 than 3-5 an ionized form, their hydrophobicity accounted these...
There has been no report that investigated β(2)-adrenergic receptor (ADRB2) gene polymorphism in patients with aspirin-exacerbated respiratory disease (AERD).DNA the specimens three groups of study subjects classified AERD, aspirin-tolerant asthma (ATA) and normal controls was extracted, target DNA sequence ADRB2 amplified using a set primers to generate an amplicon 219 bp length. Allelic discrimination assay for single nucleotide polymorphisms relating expression carried out by previously...
Levels of platelet‐activating factor (PAF) in blood from 12 bronchial asthmatic patients (six atopic and six nonatopic) were measured by radioimmunoassay after lipid extraction separation high‐performance liquid chromatography. None the given disodium cromoglycate prednisolone, they instructed to take only regular medications during tests. Blood was drawn a fasting state, PAF levels compared between times when free symptoms had mild spontaneous attacks. Ten four out patients, attacks, showed...