A5090131358- X-ray Diffraction in Crystallography
- Enzyme Production and Characterization
- Crystallization and Solubility Studies
- Cleft Lip and Palate Research
- Bone health and treatments
- Orthodontics and Dentofacial Orthopedics
- Bone Metabolism and Diseases
- Laser Design and Applications
- Temporomandibular Joint Disorders
- Ferroelectric and Piezoelectric Materials
- Advancements in Battery Materials
- dental development and anomalies
- X-ray Spectroscopy and Fluorescence Analysis
- Bone Tissue Engineering Materials
- Craniofacial Disorders and Treatments
- Solid State Laser Technologies
- Titanium Alloys Microstructure and Properties
- Maternal and Perinatal Health Interventions
- Inflammatory mediators and NSAID effects
- Microwave Dielectric Ceramics Synthesis
- Dental Implant Techniques and Outcomes
- SARS-CoV-2 detection and testing
- Chemical Synthesis and Characterization
- Child Abuse and Trauma
- Advanced ceramic materials synthesis
Tohoku University
2016-2025
Tohoku University Hospital
2012-2025
Kazusa DNA Research Institute
2025
Aderans (Japan)
2025
Chiba Institute of Technology
2003-2017
Health and Human Development (2HD) Research Network
2009
Division of Chemistry
2007
Zero to Three
2004
Northwestern University
2002-2004
Nihon University
2002
In orthodontics, undesirable movement of anchor teeth during tooth and relapse moved after treatment are the main causes unsuccessful results. If these movements could be prevented with pharmacological agents, a less complex orthodontic force system extensive retention would required. The purpose this study was to examine effect topical administration bisphosphonate (risedronate), potent blocker bone resorption, on in rats. first experiment, both right left upper molars were buccally...
Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect local administration clodronate on orthodontic tooth movement. Both right left upper first molars 26 7-week-old male Wistar rats were moved buccally with standardized expansion spring. Clodronate solution injected into sub-periosteum area adjacent molar every third day during experimental period. served as control.
During orthodontic tooth movement, the activation of vascular system in compressed periodontal ligament (PDL) is an indispensable process tissue remodeling. We hypothesized that compressive force would induce angiogenesis PDL through production endothelial growth factor (VEGF). examined localization VEGF rat tissues during experimental movement vivo, and effects continuous on angiogenic activity human cells vitro. adjacent to hyalinized alveolar bone side showed marked immunoreactivity. mRNA...
Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation orthodontic tooth movement, and, if so, determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated force during specific phases estrous cycle. Tooth movement animals that principally estrus about 33% greater than such pro-estrus (p < 0.05). Serum estradiol levels also varied...
ABSTRACT Actinomyces naeslundii and Schaalia odontolytica belong to the most predominant nitrite‐producing bacteria in oral microbiome. Nitrite has antibacterial vasodilatory effects that may contribute maintaining systemic health. We have previously elucidated metabolic characteristics of activity Veillonella species environmental factors. However, this is still unknown for species. Furthermore, these are thought degrade nitrite. Therefore, study aimed comprehensively elucidate factors (pH,...
Graves’ disease (GD) is an autoimmune disorder that can be difficult to distinguish from other diseases due symptom similarity. The exacerbation of GD owing delayed diagnosis a serious issue, and novel accessible health screening system needed. Therefore, this study investigated the association between thyroid hormone levels in women’s hair evaluated prediction accuracy non-invasive type sample. By optimizing pretreatment analysis techniques using liquid chromatography–mass spectrometry...
Patients with malocclusion, especially those in need of surgical correction, have lower health related quality life (HRQOL) and higher anxiety. We investigated the changes HRQOL psychological status following jaw surgery patients facial deformities. Thirty-one adult orthodontic admitted to Tohoku University Hospital diagnosed as malocclusion requiring were recruited for study. The severity was assessed by Severity Score (SS) which is based on their cephalometric radiographs. They divided...
To investigate histologically the effect of initially light and gradually increasing force on tooth movement in rat.Cuboids made neodymium-iron-boron magnets (experimental groups) or titanium (control group) were bonded to lingual surface right left maxillary first molars 18-week-old male Wistar rats. The initial distances between materials 1.0 mm generating 4.96 gf group 1) 1.5 2.26 2). In three groups, rats killed 1, 3, 7, 10, 14 days after treatment. Histological sections prepared stained...
The exact profiles of the clinical symptoms related to SARS-CoV-2 Omicron variant (B.1.1.529) remain largely uncertain. Therefore, this study aimed clarify manifestations infection with variant. We enrolled individuals who were tested by quantitative nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) test at a large screening center in city Japan during B.1.1.529 wave between January and May 2022, after contact COVID-19 patients. Swab tests planned be performed...
Functional constipation is the most common gastrointestinal disorder during childhood. Oral stimulation (mastication and toothbrushing) reportedly improves bowel movements, but association between daily toothbrushing behavior functional remains unknown. Data (n = 83,660) from fetal records 104,059) in Japan Environment Children's Study, an ongoing prospective birth cohort, were analyzed to investigate impact of frequency on childhood, using ROME III diagnostic criteria. After multiple...
The kinetics of the solid‐state reaction strontium carbonate with anatase and rutile in air carbon dioxide were studied by use a thermobalance. product was single‐phase SrTiO 3 all cases. relation between fraction reacted time fitted to Jander equation Carter for both rutile. For rate constant did not differ from that air. rates ⅓ ⅛ anatase, respectively. In k vs 1/ T gave two straight lines different slopes having break point at ∼820°C dioxide. activation energies higher lower temperature...
Periodontal ligament (PDL) cells play an essential role in orthodontic tooth movement. We recently reported that clodronate, a non-N-containing bisphosphonate, strongly inhibited movement rats, and thus could be useful adjunct for treatment. However, it is not clear how clodronate affects the responses of PDL to force. In this study, we hypothesized prevents mechanical stress-induced production prostaglandin E 2 (PGE ), interleukin-1β (IL-1β), nitric oxide (NO) human cells. A compressive...
Sports-related dental injuries, such as tooth fracture, loosening, and avulsion, are a major concern among young athletes because they directly impair oral function. Although the preventive efficacy of mouthguards has been well established, prevalence sports-related injuries remains high athletes. The aim this study is to identify variables contributing risk by conducting survey on large population in Miyagi prefecture. A cross-sectional was conducted with school-aged (aged 6–15 years, n =...
Cleft lip and/or palate is among the most prevalent congenital birth defects, and negatively affects maternal psychological status may consequently result in higher prevalence of child maltreatment. However, association childbirths infants with cleft emotional involvement still remains unclear. We examined between mother-to-infant bonding, using data from Japan Environment Children's Study, a nationwide cohort study.A cross-sectional study jecs-an-20,180,131 dataset was performed. A total...
In response to the COVID-19 pandemic caused by SARS-CoV-2 in 2020, we conducted drive-through nasopharyngeal swab testing for Sendai city, Japan, since April 2020. All tested individuals were judged advance public health centers necessity of undergoing test with possible contact history and/or symptoms suggestive COVID-19. this study, identify predictors positivity more efficient and evidenced selection suspected individuals, enrolled 3,540 consecutive first 7 months program, data regarding...
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) is currently the world’s largest public health concern. This study evaluated COVID-19 transmission risks in people group living environments. A total of 4550 individuals with a history recent contact patients at different places (dormitory/home/outside residences) and levels (close/lower-risk) were tested for SARS-CoV-2 viral RNA using nasopharyngeal swab test between July...
The purpose of this study was to investigate whether there are any differences in tooth movement or the response periodontal tissue orthodontic force when is applied at different times day. One hundred 6‐week‐old male Wistar rats were divided into one control group without application and three experimental groups based on time day upper first molars. Animals whole‐day received continuously throughout period, while animals light‐ dark‐period only during light (07:00–19:00) dark period...