A5073345331- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Inorganic and Organometallic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Semiconductor materials and devices
- Oxidative Organic Chemistry Reactions
- Graphene research and applications
- Synthetic Organic Chemistry Methods
- Copper Interconnects and Reliability
- Carbon Nanotubes in Composites
- Synthesis of heterocyclic compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Coordination Chemistry and Organometallics
- Synthesis and Reactions of Organic Compounds
- Vasculitis and related conditions
- Systemic Sclerosis and Related Diseases
- Synthesis and Reactivity of Heterocycles
- Chemical Reactions and Isotopes
- Organic and Inorganic Chemical Reactions
- Fluorine in Organic Chemistry
- Biological Activity of Diterpenoids and Biflavonoids
- Advanced Synthetic Organic Chemistry
- Vascular Tumors and Angiosarcomas
- Systemic Lupus Erythematosus Research
Kyoto Prefectural University of Medicine
2015-2024
Morinomiya University of Medical Sciences
2024
Kurashiki Central Hospital
2023-2024
Osaka Prefecture University
2005-2022
Kyoto Prefectural University
2021
Tokushima University
2004-2019
North Medical Center
2019
Kanazawa University
2016
Toshiba (Japan)
2003-2014
Photonics Electronics Technology Research Association
2012-2014
The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves as polymodal detector of pain-producing chemical and physical stimuli. It has been proposed ATP, released from different cell types, initiates the sensation pain by acting predominantly on nociceptive ionotropic purinoceptors located nerve terminals. In this study, we examined effects extracellular ATP VR1. cells expressing increased currents evoked or protons through activation metabotropic P2Y 1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific and stereoselective reactions. I. Preparation of amines from alcoholsOyo Mitsunobu, Makoto Wada, Takashi SanoCite this: J. Am. Chem. Soc. 1972, 94, 2, 679–680Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/ja00757a085https://doi.org/10.1021/ja00757a085research-articleACS PublicationsRequest reuse permissionsArticle...
The effects of thinning the FLOTEX EEPROM tunnel oxide on its reliability are investigated using capacitors and cell structures with thickness ranging from 47 to 100 AA. A low-electric-field leakage current is induced by charge injection stressing, it increases decreasing thickness. Its conduction mechanism found be different that caused positive accumulation in has opposite dependence. corresponding increase loss a write/erase (W/E)-cycled observed room-temperature retention test. When...
Abstract In the presence of metallic bismuth, bismuth(III) chloride–metallic zinc, or iron, allylic halides have been found to react with aldehydes under mild conditions give corresponding homoallylic alcohols in high yields chemo-, regio-, and stereoselectivity. Allylic also at room temperature tetrahydrofuran–water by using aluminium afford expected yields.
Copper (Cu) dual-damascene interconnects with a self-formed MnSi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> O xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> barrier layer were successfully fabricated. Transmission electron microscopy shows that approximately 2-nm thick and continuous was formed at the interface of Cu dielectric SiO xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , no via bottom because oxygen during...
Abstract Rheumatoid arthritis (RA) is characterized by massive synovial proliferation, angiogenesis, subintimal infiltration of inflammatory cells and the production cytokines such as TNF-α IL-6. Allograft factor-1 (AIF-1) has been identified in chronic rejection rat cardiac allografts well tissue inflammation various autoimmune diseases. AIF-1 thought to play an important role immune processes, especially those involving macrophages. In current work, we examined expression tissues measured...
We report a synthesis of closely packed multi-walled carbon nanotube (MWCNT) forest by multi-step growth method, including new approach to immobilize catalytic nanoparticles, using plasma-based chemical vapor deposition. The CNT packing density reaches one-half the theoretical value, where space 30–40% is filled with MWCNTs. This value approximately one order magnitude larger than that as-grown synthesized conventional methods. method applicable even at spatially restricted region, for...
Although melanoma is the most aggressive skin cancer, recent advances in BRAF and/or MEK inhibitors against BRAF-mutated have improved survival rates. Despite these advances, a treatment strategy targeting NRAS-mutated has not yet been elucidated. We discovered CH5126766/RO5126766 as potent and selective dual RAF/MEK inhibitor currently under early clinical trials. examined activity of panel malignant tumor cell lines including with or NRAS mutation. Eight were assessed for their sensitivity...
Abstract With consideration of the ongoing developments in treatment options for cutaneous melanoma, Japanese Skin Cancer Society published first guidelines melanoma 2007 and later revised them 2015. Here, we report on an English version 2019 Melanoma Guidelines. In this latest edition, all processes were carried out according to Grading Recommendations, Assessment, Development Evaluation system. A comprehensive work search, systematic review determination recommendations each clinical...
Abstract RCu·BF3 reacted with 1-ethoxycarbonylpyridinium chloride at the 4-position almost complete regio-selectivity (&gt;99%) to afford corresponding 1,4-dihydropyridine derivatives in high yields (81–94%). The dihydropyridines were oxidized by oxygen give 4-alkyl(aryl)pyridines (38–68%). Grignard reagents also 1-t-butyldimethylsilylpyridinium triflate regioselectivity 1,4-dihydropyridines, which easily 4-substituted pyridines higher than above (58–70%).
Abstract Functional selectivity and stereospecificity of the intermolecular dehydration between alcohols phthalimide (III) by means diethyl azodicarboxylate (I) triphenylphosphine (II) was examined. The reaction allyl alcohol, 2-chloroethanol or (±)-ethyl lactate with I, II, III led to formation corresponding N-alkylphthalimide. further applied synthesis esters N-phthaloyl-α-amino acid. (S)-(−)-ethyl 2-hydroxy-3-phenylpropionate converted into (R)-(+)-N-phthaloylphenylalanine ethyl ester...
In the presence of bismuth(III) chloride–metallic aluminium, allylic halides have been found to react with aldehydes at room temperature in tetrahydrofuran–water afford corresponding homoallylic alcohols high yields.
Abstract In the presence of a catalytic amount bismuth(III) trichloride (5 mol%), silyl enol ethers react with aldehydes at room temperature in dichloromethane to give corresponding aldols good yields. Silyl also have been found α,β-unsaturated ketones afford 1,5-dicarbonyl compounds, Michael adducts The intermediate aldol reaction (the ethers) and were obtained
Ascitic feline coronavirus (FCoV) RNA was examined in 854 cats with suspected infectious peritonitis (FIP) by RT-PCR. The positivity significantly higher purebreds (62.2%) than crossbreds (34.8%) (P<0.0001). Among purebreds, the positivities Norwegian forest cat (92.3%) and Scottish fold (77.6%) were average of (P=0.0274 0.0251, respectively). males (51.5%) females (35.7%) (P<0.0001), whereas no gender difference has generally been noted FCoV antibody prevalence, indicating that FIP more...