A5039962928- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- Diet and metabolism studies
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Chronic Kidney Disease and Diabetes
- Sodium Intake and Health
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Mass Spectrometry Techniques and Applications
- Alcohol Consumption and Health Effects
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Diabetes Management and Research
- Body Composition Measurement Techniques
- IL-33, ST2, and ILC Pathways
- Peripheral Artery Disease Management
- Adrenal and Paraganglionic Tumors
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Frailty in Older Adults
Kyoto Prefectural University of Medicine
2015-2024
Japanese Red Cross Society Kyoto Daini Hospital
2024
Kyoto first Red Cross hospital
2022-2023
Nagoya City University
1988-2016
Center for Global Health
2016
National Center for Global Health and Medicine
2016
Cambridge University Press
2016
New York University Press
2016
Hamamatsu University School of Medicine
1980-2006
Hamamatsu University
1989
Microplastics (MPs) are small particles of plastic (≤5mm in diameter). In recent years, oral exposure to MPs living organisms has been a cause concern. Leaky gut syndrome (LGS), associated with high-fat diet (HFD) mice, can increase the entry foreign substances into body through intestinal mucosa.We aimed evaluate pathophysiology outcomes consuming and simultaneous intake MPs, focusing on endocrine metabolic systems.C57BL6/J mice were fed normal (ND) or HFD without polystyrene MP for 4 wk...
The clinical significance of polymorphisms in the interleukin-28B gene encoding interferon (IFN)-λ3, which has antiviral effects, is known chronic HCV but not HBV infection. Thus, we measured IFN-λ3 levels patients with and investigated its association nucleos(t)ide (NUC) analogue administration.Serum level was 254 varying conditions using our own high sensitivity method. resulting values were compared various variables. In addition, cell lines originating from organs cultured NUCs,...
Metabolically healthy obesity (MHO) is a unique phenotype that apparently protects people from the metabolic complications of obesity. The association between MHO and incident CKD unclear. Thus, this study investigated CKD.A total 3136 Japanese participants were enrolled in an 8-year follow-up cohort 2001. status was assessed by common clinical markers: BP, triglycerides, HDL cholesterol, fasting plasma glucose concentrations. Body mass index ≥25.0 kg/m(2) defined as proteinuria or eGFR <60...
Skipping breakfast or irregular is associated with poor glycemic control. However, a relationship between the timing of dinner and control in people type 2 diabetes remains indefinite. Therefore, we investigated late-night-dinner diabetes. We performed questionnaire survey for lifestyle factors this cross-sectional study. defined having later than eight pm as late-night-dinner. examined differences clinical metabolic parameters those who have do not have. also HbA1c, using multiple...
A detailed procedure of an extremely sensitive method for quantitation methamphetamine and amphetamine in human hair by gas chromatography (GC)/chemical ionization (CI) mass spectrometry (MS) is presented. N-methylbenzylamine was used as internal standard. The samples, after extraction with organic solvent, were derivatized trifluoroacetic anhydride before the GC/MS analysis. Quantitation made quasi-molecular ions derivatives selected ion monitoring CI mode. detection limit about 10 pg...
Sarcopenia has reportedly been associated with increased risk of mortality in general populations. However, few studies have investigated the association between sarcopenia and older people type 2 diabetes mellitus (T2D). This study aimed to investigate effect on incident all-cause T2D.Low muscle strength were set at handgrip <28 kg for men <18 women, low skeletal mass index (SMI), evaluated using impedance body composition analyzer, SMI <7.0 kg/m2 <5.7 women. People who had both diagnosed...
Abstract Introduction Brazilian green propolis is an important honeybee product that considered beneficial for health. Here, we examined the therapeutic potential of dietary supplementation with against sarcopenic obesity using Db/Db mice. Methods Db/m mice fed a normal diet alone and alone, or supplemented different amounts (0.08, 0.4 2%), were effects on obesity. Results Propolis improved glucose tolerance ( P < 0.001), increased grip strength 0.001) weight soleus = 0.006) plantaris...
OBJECTIVE Recent study has suggested that not only the presence of hypertension but also variability in systolic blood pressure (SBP) are risk factors for vascular disease and organ damage. The aim this was to investigate relationship between visit-to-visit SBP change urinary albumin excretion (UAE) or development albuminuria patients with type 2 diabetes. RESEARCH DESIGN AND METHODS We measured 354 consecutive at every visit during 1 year calculated coefficient variation (CV) SBP. performed...
Background and Aims Many nutritional epidemiological studies have shown that high consumption of trans fatty acids can cause several adverse effects on human health, including cardiovascular disease, diabetes, cancer. In the present study, we investigated effect innate immunity in gut by observing mice fed with a diet acids, which been reported to dysbiosis. Methods We used C57BL6/J them normal (ND) or high-fat, high-sucrose (HFHSD) high-trans acid, (HTHSD) for 12 weeks. 16S rRNA gene...
Background and Aims: Emerging evidence has revealed that innate lymphoid cells (ILCs) play a key role in regulating metabolic disorders. Here, we investigated the of group 3 ILCs (ILC3s) modulation Non-alcoholic fatty liver disease (NAFLD). Methods: RORγ gfp/gfp (RORgt KI/KI) Rag2 −/− mice with administration A213, RORgt antagonist, fed high-fat-diet (HFD) for 12 weeks, were used. We performed flow cytometry, real time PCR, lipidomics analysis serum liver, used RAW264.7 murine primary...
Background: Erythritol, a sugar alcohol, is widely used as substitute for in diets patients with diabetes or obesity. Methods: In this study, we aimed to investigate the effects of erythritol on metabolic disorders induced by high-fat diet C57BL/6J mice, while focusing changes innate immunity. Results: Mice that were fed and administered water containing 5% (Ery group) had markedly lower body weight, improved glucose tolerance, higher energy expenditure than control mice (Ctrl (n = 6)....
A low-carbohydrate diet based on animal sources is associated with higher all-cause mortality, whereas a vegetable-based lower cardiovascular disease mortality. It has been suggested that acid/base imbalance might play an important role in some cardiometabolic abnormalities. The aims of the present study were to evaluate whether carbohydrate intake quality dietary protein and acid load, these are related metabolic syndrome patients type 2 diabetes.The cross-sectional involved 149 diabetes....
Aim To investigate the association between sarcopenia and blood pressure parameters in older patients with type 2 diabetes. Methods This was a cross‐sectional study of 146 Body composition evaluated by bioimpedance analysis. The skeletal muscle mass index (kg/m ) defined as appendicular / square height. Patients both handgrip strength <26 kg for men <18 women, <7.0 kg/m <5.7 women were diagnosed sarcopenia. We measured systolic (SBP) at every visit 1 year calculated coefficient...
The aim of this cross-sectional study was to examine the association between geriatric nutritional risk index (GNRI) and prevalence sarcopenia in people with type 2 diabetes (T2DM). Having both low handgrip strength (<28 kg for men <18 women) skeletal muscle mass (<7.0 kg/m2 <5.7 diagnosed as sarcopenia. GNRI estimated by formula below: = (1.489 × serum albumin level [g/L]) + (41.7 [current body weight (kg)/ideal (kg)]). Participants were dichotomized on basis their scores (GNRI...
Abstract Aim Inulin, a soluble dietary fiber, is source of energy for the host while metabolites, such as short-chain fatty acids (SCFAs), produced in gut through bacterial fermentation exerts anti-obesity effect. In this study, we aimed to apply metabolomics approach and clarify role fiber on glucose lipid metabolism under calorie-matched condition. Materials methods Eight-week-old male C57BL/6J mice were fed high-fat/high-sucrose based diet containing maltodextrin or inulin 12 weeks pair...