A5008910767- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Immunotherapy and Immune Responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Diseases and Glomerulopathies
- IgG4-Related and Inflammatory Diseases
- Eosinophilic Disorders and Syndromes
- Hematopoietic Stem Cell Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Advanced Glycation End Products research
- Lymphoma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Lipid metabolism and disorders
- Otitis Media and Relapsing Polychondritis
- Sarcoidosis and Beryllium Toxicity Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- GaN-based semiconductor devices and materials
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cerebral Venous Sinus Thrombosis
Feinstein Institute for Medical Research
2021-2024
Okayama University
2015-2024
The University of Tokyo
2024
Tokyo University of Technology
2024
Chuo University
2024
Northwell Health
2024
College of Industrial Technology
2023
Hiroshima University Hospital
2023
Nihon University
2023
Yokohama National University
2023
Con A-induced hepatic injury of mice accompanied by elevated transaminase was inhibited after in vivo depletion liver NK cells and NK1+ T with intermediate TCR anti-NK1 Ab or anti-IL-2Rbeta Ab. However, alone anti-asialo-GM1 did not inhibit injury. Although IL-2R expression CD4+ high (TCRhigh) IL-4 mRNA mononuclear cells, exogenous engendered endowed the TCRhigh cells. It also found that treatment anti-IL-4 before A administration In addition, although induce MHC class I-deficient mice,...
In addition to the major intrathymic pathway of T cell differentiation, extrathymic pathways such differentiation have been shown exist in liver and intestine. particular, hepatic cells receptors or CD3 intermediate levels (i.e., receptor cells) always contain self-reactive clones sometimes appear at other sites, including target tissues autoimmune diseases tumor sites malignancies. To prove their origin self reactivity, this study we used thymectomized, irradiated (B6 x C3H/He) F1 mice...
The pharmacological properties of magnolol and hõnokiol, neolignane derivatives, extracted from Magnolia officinalis, used in Chinese Japanese traditional medicine, for neurosis gastrointestinal complaints, were investigated. Magnolol hõnokiol produced sedation, ataxia, muscle relaxation a loss the righting reflex with an increase dose 50 to 500 mg/kg i.p. at suppressed spinal reflexes young chicks similar manner, but much longer duration action than mephenesin. Pretreatment mice 100...
Experiments to date have revealed a population of T cells that carry intermediate (int) levels TCR (or CD3) and express IL-2R beta-chain (IL-2R beta) in mouse liver. Such int also reside other immune organs, although low numbers. On the hand, NK1.1+ with do thymus peripheral organs. To determine relationship two types cells, we characterized CD3 throughout organs terms phenotype, V beta repertoire, morphology. Although both beta+ are classified as present within cells. The majority liver...
The liver is a major site of generation extrathymic T cells with unique properties (e.g., expressing intermediate TCR and containing self-reactive clones). We investigated herein whether the levels alpha beta varied in various organs as function age. A systematic examination number mononuclear BALB/c mice revealed that hepatic MNC increased age whereas thymocytes decreased. These changes were more striking fed under conventional conditions than specific pathogen-free condition. age-dependent...
Mouse liver contains both IL-2Rβ- (or low positive) high T-cell receptor (TCR(hi)) cells and IL-2Rβ+ intermediate TCR (TCR(int)) cells. TCR(int) consist of natural killer 1.1 (NK1)+ NK1- subsets. increase constantly with age whereas TCR(hi) decrease. NK1+ cell proportions in the until middle decrease thereafter. Although other organs are few regardless age, gradually appear lymphoid aging. Skewed usage Vβ7 Vβ8 was observed but predominance less obvious organs. V α14 messenger RNA (mRNA)...
This paper concerns field survey and laboratory experiment on the inactivation of pathogenic bacteria during sludge treatment processes with particular emphasis anaerobic digestion process. We surveyed by sampling various types sludges from 17 wastewater plants located in Japan counting number sampled sludges. The we counted included fecal coliform groups, enterococcus salmonella. median groups primary was found to be 105 MPN/g, while digested decreased 103 MPN/g. also confirmed that...
Gauge invariance is of fundamental importance to make physically meaningful predictions. In superconductors, the use mean-field Hamiltonians that lack $U(1)$ symmetry often leads gauge-dependent results. While solutions this problem for linear response conventional superconductors have been well-known, a unified understanding unconventional or nonlinear responses has not established. This study provides full detail general theoretical framework allows us compute at arbitrary orders in...
Evidence is presented for the existence of a unique T cell population which expressed one natural killer (NK) markers, CD56 antigen, in humans. Although such CD56+ cells were minor peripheral blood (< 10%), they abundant liver (up to 50%), was recently demonstrated be major organ extrathymic differentiation mice. As case mice, these humans contained higher proportion gamma delta than did CD56- cells, double-negative CD4-8- and had morphology large granular lymphocytes. This tended elevated...
To evaluate clinical links between levels of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) and relapse in patients with ANCA-associated vasculitis (AAV) using a data set from 2 nationwide prospective cohort studies.From the studies, MPO-ANCA-positive who achieved remission during 6 months after induction therapy were enrolled. We measured MPO-ANCA at 0, 3, 6, 12, 18, 24, time relapse. The primary outcome measure was A nested case-control analysis multivariable performed to...
Objective In systemic lupus erythematosus ( SLE ), an autoimmune disease associated with multiple organ involvement, the development of nephritis determines prognosis, and arthritis impairs quality life. Galectin 9 (Gal‐9, Lgals9 ) is a β‐galactoside–binding lectin that has been used for clinical application in diseases, since recombinant Gal‐9, as ligand T cell immunoglobulin mucin domain–containing protein 3 TIM ‐3), induces apoptosis activated CD 4+ ‐3+ Th1 cells. This study was...
Abstract Systemic lupus erythematosus (SLE) damages multiple organs by producing various autoantibodies. In this study, we report that decreased microRNA (miR)-200a-3p causes IL-2 hypoproduction through zinc finger E-box binding homeobox (ZEB)1 and C-terminal protein 2 (CtBP2) in a lupus-prone mouse. First, performed RNA sequencing to identify candidate microRNAs mRNAs involved the pathogenesis of SLE. We found miR-200a-3p was significantly downregulated, whereas its putative targets, ZEB2...
Symmetry properties of Cooper pairs play a pivotal role in studies on topological superconductivity. Unconventional superconductors, whose pairing symmetries are different from conventional Bardeen-Cooper-Schrieffer have been paid attention to as platform However, most superconductors actually the one and these usually considered be topologically trivial. In this work, combining real-space momentum space approaches developed recently, we conduct classifications time-reversal symmetric with...
SUMMARY When C57Bl/6 mice were exposed to restraint stress for 12 h or 24 h, lymphocytopenia was induced in the liver, spleen, and thymus. We examined which types of lymphocytes sensitive resistant such by a immunofluorescence test. T cells thymic origin while NKT NK resistant. In contrast increase proportion cells, activity liver against YAC-1 targets decreased at after stress. On other hand, their cytotoxicity syngeneic thymocytes increased parallel with an proportion. perforin −/– B6...
To determine prognostic factors of methotrexate-associated lymphoproliferative disorder (MTX-LPD) and evaluate the efficacy safety biological therapy in rheumatoid arthritis (RA) complicated with MTX-LPD.Thirty RA patients who developed MTX-LPD were investigated this study. We compared clinical laboratory parameters achieved regression LPD by MTX withdrawal those required chemotherapy evaluated course after development.Twenty-three (76.7%) withdrawal. Chemotherapy-free had a tendency shorter...
Abstract Background It is not elucidated that there treatment-related damage in elderly patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods Elderly (≥ 75 years of age) were enrolled from two nationwide prospective inception cohort studies. The primary outcome was 12-month Vasculitis Damage Index (VDI) score. Secondary outcomes included serious infections within 6 months, total VDI score, remission, and relapse. Patient characteristics compared across...
Depletion of both natural killer 1.1 + (NK1 ) intermediate αβ T‐cell receptor (int T) cells and NK by in vivo treatment with anti‐NK1 antibody greatly increased hepatic metastases intravenously injected EL4 as well pulmonary 3LL C57BL/6 mice. However, depletion alone anti‐asialo GM1 (AGM1) did not increase the either organ. Interleukin‐12 (IL‐12) administration into mice induced strong cytotoxicities cell‐depleted liver lung mononuclear (MNC) comparable to those without NK‐cell inhibited In...
High-mobility group box-1 (HMGB1) protein acts as a transcription factor in the nucleus and also pro-inflammatory cytokine when released into extracellular fluids. The presence of higher levels HMGB1 is reported gingival crevicular fluid from periodontal patients. Since proliferation bacteria within pocket closely involved exacerbation disease, it hypothesized that causes release HMGB1. Immunohistochemical staining inflamed gingiva revealed exclusively dislocated to cytoplasm epithelium,...