A5078055317- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- IgG4-Related and Inflammatory Diseases
- Otitis Media and Relapsing Polychondritis
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Chronic Myeloid Leukemia Treatments
- Lipid metabolism and disorders
- Lymphoma Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Rheumatoid Arthritis Research and Therapies
- Immune Response and Inflammation
- Inflammatory Myopathies and Dermatomyositis
- Antimicrobial Peptides and Activities
- Ocular Diseases and Behçet’s Syndrome
- Acute Lymphoblastic Leukemia research
- Kruppel-like factors research
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Complement system in diseases
- Click Chemistry and Applications
Okayama University
2017-2021
Weatherford College
2021
Okayama Saiseikai General Hospital
2015-2019
Universidade Federal de São Paulo
2019
Daiichi Sankyo (Germany)
2018
Daiichi-Sankyo (South Korea)
2018
Pfizer (United States)
2018
Kyowa Hakko Kirin (Singapore)
2018
Boehringer Ingelheim (South Korea)
2018
Okayama University Hospital
2017
Abstract Systemic lupus erythematosus (SLE) damages multiple organs by producing various autoantibodies. In this study, we report that decreased microRNA (miR)-200a-3p causes IL-2 hypoproduction through zinc finger E-box binding homeobox (ZEB)1 and C-terminal protein 2 (CtBP2) in a lupus-prone mouse. First, performed RNA sequencing to identify candidate microRNAs mRNAs involved the pathogenesis of SLE. We found miR-200a-3p was significantly downregulated, whereas its putative targets, ZEB2...
Abstract Background While survival of systemic lupus erythematosus (SLE) patients has improved substantially, problems remain in the management their emotional health. Medium to high-dose glucocorticoid doses are known worsen health; effect is unclear among receiving relatively low-dose glucocorticoids. This study aims investigate association between low and health disease activity state (LLDAS). Methods cross-sectional drew on data from SLE 10 Japanese institutions. The participants were...
Abstract Renal impairment is a major concern in patients taking high-dose methotrexate (MTX) for malignancy, but it has not been fully explored rheumatoid arthritis (RA) low-dose MTX. This study aimed to elucidate the dose-dependent effects of MTX on renal function with RA. We retrospectively reviewed 502 consecutive RA who were prescribed ≥ 1 year at Okayama University Hospital between 2006 and 2018. The primary outcome was change estimated glomerular filtration rate (eGFR) over year....
Abstract Global DNA hypomethylation in CD4+ cells systemic lupus erythematosus (SLE) was suggested to play a key role the pathogenesis. To identify new methylation-sensitive genes, we integrated genome-wide methylation and mRNA profiling data of MRL/lpr (MRL) C57BL6/J (B6) mice. We identified Cathepsin E ( Ctse ), which 13 methyl-CpGs within 583 bp region intron 1 were hypomethylated, upregulated MRL compared with B6 One methyl-CpGs, mCGCG 93.3 ± 2.05% methylated mice, while 80.0 6.2%...
Nakano, Yasuhiro MD; Miyawaki, Yoshia Sada, Ken-Ei MD, PhD; Yamamura, Yuriko Kano, Yuzuki Hayashi, Keigo Watanabe, Haruki Matsumoto, Yoshinori Kawabata, Tomoko Wada, Jun PhD Author Information
Objective Although several autoantibodies have been identified for polymyositis/dermatomyositis (PM/DM) diagnosis, the clinical impact of these antibodies is yet to be elucidated. Methods Patients with PM/DM at Okayama University Hospital from 2012 2016 were historically enrolled, and antibody profiles analyzed using line immunoassay. Hierarchical cluster analysis was performed based on serological anti-aminoacyl-tRNA synthetase (ARS) antibodies, including anti-Jo-1, PL-7, PL-12, EJ, OJ,...
Activity of transcription factors is normally regulated through interaction with other factors, chromatin remodeling proteins and transcriptional co-activators. In distinction to these well-established controls gene expression, we have uncovered a unique activation model between tyrosine kinase ABL RUNX2, an osteoblastic master factor, for cancer invasion. We show that directly binds to, phosphorylates, activates RUNX2 its SH2 domain in activity-dependent manner the complex formation...
Abstract Background The aim of the present study was to evaluate association between histology active and chronic lesions urinary protein serum creatinine (SCr) levels, as common clinical endpoints in trials for lupus nephritis (LN). Methods In total, 119 patients diagnosed with LN class III, IV, V, defined by International Society Nephrology/Renal Pathology Society, 1990 2015, were enrolled study. Multiple regression analysis performed explore semi-quantitative histological variables...
Double-stranded RNA (dsRNA) sensors including TLR3, MDA5 and RIG-I are expressed in epidermal keratinocytes play an important immunological role by enhancing various innate adaptive immune responses. Although the of elevated extracellular calcium concentration keratinocyte differentiation is well understood, effect high on dsRNA not studied. We investigated alterations sensor expression antiviral activity induced a keratinocytes. Normal human (NHEKs) were stimulated with and/or synthetic...
Numerous patients develop diabetes in response to glucocorticoid therapy. This study explored the efficacy, safety, and preventive potential of dipeptidyl peptidase-4 inhibitor, linagliptin (TRADJENTA®), development glucocorticoid-induced mellitus.From December 2014 November 2015, we recruited non-diabetic Japanese scheduled for treatment with daily prednisolone ≥20 mg. Enrolled had at least one following risk factors mellitus: estimated glomerular filtration rate ≤ 60 mL/minute/1.73 m2; age...
Objective Serologically active clinically quiescent (SACQ)-SLE is a subtype of systemic lupus erythematosus (SLE); most SACQ-SLE patients relapse. Although complement and/or anti-dsDNA level fluctuations during SACQ status are reportedly not useful for predicting relapse, they might be in specific clinical settings. We aimed to assess the correlation between future relapse and progressive reductions serum levels following remission with hypocomplementemia . Methods retrospectively reviewed...
Background: This study aimed to identify the clinical subgroups of polymyalgia rheumatica (PMR) using cluster analysis and compare outcomes among identified subgroups. Methods: We enrolled patients with PMR who were diagnosed at Okayama University Hospital, Japan between 2006 2017, met 2012 European League Against Rheumatism/American College Rheumatology provisional classification criteria for PMR, treated glucocorticoids. Hierarchical variables selected by principal component was performed...
Takayasu arteritis (TAK) is a large-vessel vasculitis affecting the aorta and its main branches. Hemoptysis can be experienced as respiratory manifestation, but origination from bronchial artery rare. Ulcerative colitis (UC) shares genetic similarities with TAK; HLA-B52*01 associated TAK UC. We herein report patient who presented hemoptysis right was diagnosed during follow-up of Transcatheter embolization performed, prednisolone tocilizumab induced remission. Complication should considered...
Bronchial involvement alone is a rare initial manifestation of granulomatosis with polyangiitis (GPA). Herein, we report case refractory GPA obstructive pneumonia caused by bronchial involvement.A 65-year-old man complained 2-week cough and fever.Considering the presence opacities multiple consolidations in both lungs due to obstruction or stenosis on bronchus, which did not respond antibiotics, proteinase-3-antineutrophil cytoplasmic autoantibody positivity, he was diagnosed GPA. Positron...
Abstract Background Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM characterized weakness due to necrosis and regeneration myofibers. Here we report the first case with acute respiratory failure treated noninvasive pressure support ventilation in addition immunosuppressants. Case presentation A 59-year-old woman who had been 2.5 mg/day rosuvastatin calcium for 5 years stopped taking drug 4 months before admission our...
Objective The objective of this study was to evaluate the chronic damage associated with pregnancies before and after diagnosis systemic lupus erythematosus (SLE). Methods Using childbearing-aged female SLE patient data registered at Okayama Showa University Hospitals, a nested case-control analysis performed investigate relationship between pregnancy using Systemic Lupus International Collaborating Clinics/American College Rheumatology Damage Index (SDI). Results Pregnancy occurred in 22...
<h3>Background</h3> TAFRO syndrome has recently been reported as a Japanese variant of multicentric Castleman9s Disease (CD), named due to the presence thrombocytopenia, anasarca, fever, reticulin fibrosis bone marrow and organomegaly. The patients often showed hypergammaglobulinemia with autoantibody production, thus leading misdiagnosis rheumatic diseases such systemic lupus erythematosus (SLE). <h3>Methods</h3> We here report three cases syndrome. <h3>Results</h3> Case 1: A 65-year-old...
The purpose of this study was to determine the rates in-utero resolution mild fetal ventriculomegaly (MFV) based on gender. A retrospective review sonographic database performed identify cases cerebral from 2003–2007. Fetuses with gestational age > 18 weeks and MFV 2 or more subsequent examinations at least 3 apart were included. additional congenital anomalies, evidence obstruction cerebrospinal fluid pathways, known aneuploidy, in which gender could not be determined excluded. defined as a...
Lymphoproliferative disorders (LPDs) are sometimes found in patients with autoimmune diseases receiving immunosuppressive treatments. However, LPDs Takayasu arteritis (TAK) were not reported previously. A 41-year-old woman TAK and ulcerative colitis (UC) maintained remission 5 mg/day of prednisolone (PSL) 100 azathioprine (AZA). the follow up colonoscopy showed reddish, submucosal lesion rectum, histological examination revealed medium-to-large-sized atypical lymphocytes proliferating...
Abstract Rationale: Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder characterized by serositis and recurrent fever. Previous reports identified patients with antineutrophil cytoplasmic antibody (ANCA)-positive FMF, but vasculitis symptoms were not reported. Patient concerns: We report the case of 44-year-old man numbness. He had history 3 episodes pleurisy was being treated propylthiouracil for hyperthyroidism. Because he ANCA-positive, we suspected drug-induced...