A5100708308- Cyclopropane Reaction Mechanisms
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Synthesis and Catalytic Reactions
- Lipoproteins and Cardiovascular Health
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Diabetes Treatment and Management
- Estrogen and related hormone effects
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Asymmetric Hydrogenation and Catalysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Takotsubo Cardiomyopathy and Associated Phenomena
- Carbohydrate Chemistry and Synthesis
- Receptor Mechanisms and Signaling
- Cardiac Structural Anomalies and Repair
- Organic Chemistry Cycloaddition Reactions
- Catalytic C–H Functionalization Methods
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Eosinophilic Disorders and Syndromes
Shimane University
2013-2025
Riso Kagaku (Japan)
2011-2019
University of Shimane
2012-2017
Shimane University Hospital
2013-2017
Keio University
2015
National Center For Child Health and Development
2009
Hokkaido University
1994-2007
Sumitomo Dainippon Pharma (Japan)
2003-2005
Meisei University
2002
Scripps Research Institute
1998
Complicated oligosaccharides such as dodecasaccharide 1 can be constructed by a new solid-phase strategy. The attachment to the polymeric support (gray sphere) is through photolabile linker (structure I), and thioglycosides serve carbohydrate donors. Bn=benzyl, Bz=benzoyl.
Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] catalyzes aromatic substitution reactions of 3-alkyl-substituted 1-diazo-3,3-diphenyl-2-propanones to give (S)-1-alkyl-2-phenyl-2-indanones featured by a chiral quaternary carbon atom in up 98% ee, the effectiveness which has been demonstrated first enantioselective synthesis FR115427 [(S)-(+)-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride], non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.
Here, we report the case of a 79-year-old woman with massive exudative pleural effusion and hypothyroidism. The patient underwent total thyroid parathyroidectomy during pharyngoesophagectomy for hypopharyngeal cancer. She was administered hormone preparation (87.5 μg levothyroxine sodium), calcium supplementation (0.5 g lactate hydrate), active vitamin D (2 alfacalcidol). Four months after missing her regular medical appointment discontinuing medications, she developed severe effusion,...
A highly enantioselective construction of 3-oxa-1-azabicyclo[4.2.0]octanes (up to 96% ee) has been achieved by intramolecular C–H insertion α-methoxycarbonyl-α-diazoacetamides catalysed dirhodium(II) complexes incorporating N-phthaloyl-(S)-amino acids as chiral bridging ligands, which provides a new, catalytic asymmetric route key intermediates for carbapenem antibiotics.
Intramolecular C-H insertion reaction of N-alkyl-N-tert-butyl-α-methoxycarbonyl-α-diazoacetamides has been catalyzed by dirhodium(II) tetrakis[N-phthaloyl-(S)-phenylalaninate] to afford 4-substituted 1-tert-butyl-3-methoxycarbonyl-2-azetidinones with 3,4-cis stereochemistry in up 74% ee.
Rhodium(II) triphenylacetate, which features a bulky bridging ligand, has been demonstrated to exhibit an exceptionally high order of selectivity for aromatic C–H insertion over aliphatic or cyclopropanation in catalytic decompositions α-diazocarbonyl compounds, thus providing expedient and general entry variously substituted indan-2-ones.
The enantioselectivity in dirhodium(II) tetrakis[N-phthaloyl-(S) -phenylalaninate]-catalyzed cyclization of α-diazo β-keto 2,4-dimethyl-3-phenyl esters possessing substituted phenyl or vinyl groups at the insertion site was studied. substituent effects on enhancement were even more pronounced with group than group, though 80% ee could be achieved both (E)-conjugated ester and p-trifluoromethanesulfonyloxyphenyl groups.
C–C chemokine ligand 2 (CCL2)/its receptor (CCR2) axis is considered as an important signaling pathway in inflammatory diseases. TLK-19705 a novel CCR2 antagonist, (1-(1,3-dimethyl-1-H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea), and the inhibitory activity was antagonized by third extracellular loop peptide of CCR2. We examined this study effects on diabetic nephropathy atherosclerosis mouse models. Treatment with (30 mg/kg/d) for 8 weeks ameliorated...
Abstract A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids and C is described. The precursor 8 was synthesized starting from di‐ tert ‐butyl D ‐tartrate ( 47 ) via an eleven‐step sequence involving regioselective reduction of mono‐MPM (MPM = 4‐methoxybenzyl) ether 48 with LiBH 4 diastereoselective addition sodium diazoacetate α‐keto ester 10 . reaction α‐diazo 3‐butyn‐2‐one 40 in presence a catalytic amount [Rh 2 (OAc) ] gave desired cycloadduct 59...
The full potential of rhodium (II) -catalyzed intramolecular C-H insertion reactions α-diazo carbonyl compounds as a powerful tool for the construction both carbocycles and heterocycles has been developed by variation bridging ligands dirhodium catalysts : (1) Dirhodium tetrakis (triphenylacetate) featured steric bulk on demonstrated to exhibit an exceptionally high order selectivity into methylene over methine cycloalkane ring well aromatic substitution aliphatic insertion. (2) complexes...
We recently reported that the novel thyroid hormone receptor β (TRβ) selective agonists SKL-12846 and SKL-13784 reduce blood cholesterol levels without affecting thyroid-stimulating (TSH) in cholesterol-fed rats. Our aim this study was to elucidate what sets apart these SKL-compounds as TRβ with no effect on TSH. To end, we determined pharmacokinetics tissue distribution normal rats compared them those of GC-1, a liver-selective agonist concomitant The present explains why have beneficial...
The enantioselectivity in cyclopropanations catalyzed by dirhodium(II) tetrakis[3(S)-phthalimido-2-piperidinonate] has been found to be substantially improved employing ether as the rarely used solvent. Cyclopropanations of styrenes or 1,1-disubstituted alkenes with 2,4-dimethyl-3-pentyl diazoacetate are promoted this catalyst afford corresponding cyclopropane products highest levels (up 98% ee) reported date for dirhodium(II)-catalyzed intermolecular cyclopropanation reactions.
The total synthesis of zaragozic acid C has been achieved by a convergent strategy, wherein the key feature construction 2,8-dioxabicyclo[3.2.1]octane core structure is simultaneous creation C4 and C5 quaternary carbon centers Sn(OTf)2-promoted aldol coupling reaction between α-keto ester silyl ketene thioacetal derived from L- D-tartaric acids, respectively.
In our studies of the development a novel class selective estrogen receptor modulators, (+)-3-[4-(1-piperidinoethoxy)phenyl]spiro[indene-1,1'-indane]-5,5'-diol hydrochloride (1) was found to be an ligand with beneficial effects in rat models for human hot flush. Moreover, 1 have on lipid and bone metabolism while maintaining marginal uterus breasts. These findings suggest that would provide new treatment