A5087308900- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Head and Neck Cancer Studies
- Genomics, phytochemicals, and oxidative stress
- Lung Cancer Treatments and Mutations
- Endoplasmic Reticulum Stress and Disease
- Proteoglycans and glycosaminoglycans research
- Circadian rhythm and melatonin
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- interferon and immune responses
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral Infections and Immunology Research
Hiroshima University
2021-2025
Abstract Objectives Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses anticancer antiangiogenic effects in some malignant tumors. Therefore, we investigated the of on oral squamous cell carcinoma (OSCC). Methods To evaluate inhibitory effect OSCC, wound-healing assays human...
Abstract Purpose Integrin αvβ 3 is an essential molecule for tumor angiogenesis. This study aimed to investigate the anti-tumor effect of MK-0429, integrin antagonist, on oral squamous cell carcinoma (OSCC) through its inhibitory Methods In this study, we investigated MK-0429 cellular function and angiogenesis in vitro with use immortalized human umbilical vein endothelial cell, HUEhT-1, which by electroporatic transfection hTERT. The signaling pathway was examined FAK, MEK1/2 ERK 1/2...
Melatonin is a hormone that primarily produced in the pineal gland and involved wide range of biological functions. However, impact melatonin on chemotherapy-induced cell death remains to be elucidated oral squamous carcinoma (OSCC) cells. The objective this study was clarify role cisplatin-induced cytotoxicity CD44high OSCC cells.CD44high cells were cultured fibronectin-coated hydrogel. A lactate dehydrogenase assay performed evaluate death. effect Derlin-1 (DERL1) endoplasmic reticulum...
Cancer cells utilize epithelial to mesenchymal transition (EMT) during invasion and metastasis. This program has intermediate cell states with retained gained features together, referred as partial EMT. Histone demethylase LSD1 forms a complex the EMT master transcription factor Snail modify histone marks regulate target gene expression. However, little is known about formation of this Snail-dependent between Here we visualized nuclear foci signals using proximity ligation assay. We...
The low-affinity nerve growth factor receptor p75 is a stratified epithelial stem/progenitor marker of human epithelia. We found OM-1, squamous cell carcinoma (SCC) line, showed distinct cells with cluster, especially located at the center growing colony in monolayer culture. A cluster was surrounded by cytokeratin 14- and 13-expressing that settled outer margin colony. OM-1 were also capable forming tumor spheres suspension culture, an ability which attenuated inhibition p75-signaling....
Abstract PurposeIntegrin αvβ 3 is an essential molecule for tumor angiogenesis. This study aimed to investigate the anti-tumor effect of MK-0429, integrin antagonist, on oral squamous cell carcinoma (OSCC) through its inhibitory angiogenesis.MethodsIn this study, we investigated MK-0429 cellular function and angiogenesis in vitro with use immortalized human umbilical vein endothelial cell, HUEhT-1, which by electroporatic transfection hTERT. The signaling pathway was examined FAK ERK 1/2...