A5063396885- Immunotherapy and Immune Responses
- Fungal Biology and Applications
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Diabetic Foot Ulcer Assessment and Management
- Animal testing and alternatives
- Cerebral Palsy and Movement Disorders
- Gut microbiota and health
- Pesticide Exposure and Toxicity
- Cancer Research and Treatments
- Immunotoxicology and immune responses
- Balance, Gait, and Falls Prevention
- Phytochemistry and Bioactivity Studies
- Antifungal resistance and susceptibility
- Immune cells in cancer
- Nail Diseases and Treatments
- Stroke Rehabilitation and Recovery
- Carcinogens and Genotoxicity Assessment
- Advanced Nanomaterials in Catalysis
- Phytochemistry and Bioactive Compounds
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Polysaccharides and Plant Cell Walls
- Leprosy Research and Treatment
Universidade de São Paulo
2018-2023
Universidade Estadual Paulista (Unesp)
2009-2023
Universidade Cruzeiro do Sul
2014-2015
Terra
2010
Fundação de Amparo à Pesquisa do Estado de São Paulo
2010
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2010
National Council for Scientific and Technological Development
2010
Partial body weight support (BWS) systems have been broadly used with treadmills as a strategy for gait training of individuals impairments. Considering that we usually walk on level ground and BWS is achieved by altering the load plantar surface foot, it would be important to investigate some reaction force (GRF) parameters in healthy walking better implement rehabilitation protocols impairments.To describe effects unloading GRF young adults walked ground.Eighteen (27 ± 4 years old)...
Recognizing the invasive potential of dermatophytes and understanding mechanisms involved in this process will help with disease diagnosis developing an appropriate treatment plan. In report, we present histopathological, microbiological immunological features a model dermatophytosis that is induced by subcutaneous infection Trichophyton mentagrophytes healthy adult Swiss mice. Using model, observed fungus rapidly spreads to popliteal lymph nodes, spleen, liver kidneys. Similar human...
In order to attain a better understanding of the interactions between opportunist fungi and their hosts, we investigated cytokine profile associated with inflammatory response Candida albicans infection in mice solid Ehrlich tumors different degrees.Groups eight animals were inoculated intraperitoneally 5 x 106 C. 7, 14 or 21 days after tumor implantation. After 24 72 hours, euthanized intraperitoneal lavage fluid was collected. Peritoneal macrophages cultivated levels IFN-gamma, TNF-alpha,...
To better understand the interactions between opportunistic fungi and their hosts, we investigated hydrogen peroxide (H2O2), nitric oxide TNF-alpha production by peritoneal macrophages from Ehrlich tumour-bearing mice (TBM) during microbial infections. For this purpose, TBM at days 7, 14 21 of tumour progression were inoculated intraperitoneally with C. albicans evaluated after 24 72 h. We observed that showed significant increases in H2O2, levels fungal clearance day 7 infection. However,...
The noxious effects of low or effective dose exposure to single mixed pesticides on macrophage activity and the lymphohematopoietic organs were investigated. Male Wistar rats orally exposed dichlorvos, dicofol, endosulfan, dieldrin permethrin, either as combined mixtures during a 28-day study containing eight groups: one group received semipurified diet (non-treated); two groups mixture (dieldrin 0.025 mg/kg, 0.6 dicofol 0.22 dichlorvos 0.23 permethrin 5 mg/kg) an (dichlorvos 2.3 2.5...
Abstract We have recently observed that human DCs treated with low doses of antitumor chemotherapeutic agents became them more efficient to stimulate T lymphocytes, whereas treatment tumor cells concentrations drugs made immunogenic than wild type cells. In this study we aimed evaluate whether transfection DC drug-treated RNA, enhances the effectiveness DC-based vaccine, and if modulatory effects can be in vivo. To achieve these goals, C57/Bl-6 mice were s.c inoculated MC-38 10 days later...
Considering the central role of dendritic cells (DCs) on development an antitumor immune response, in this study we used a murine model to evaluate how DC transfection with drug-treated tumor cell RNA changes their phenotype, and whether enhances vivo effectiveness DC-based vaccine.MC-38 colorectal were pretreated minimum effective concentration 5-fluorouracil (5-FU), then total was extracted transfected into DCs. These DCs inoculated C57Bl/6 mice bearing subcutaneous MC-38 tumor.DC...
Background: Partial body weight support (BWS) systems have been used with treadmills as a strategy for rehabilitation of individuals gait impairment. Considering that over ground is the commonly surface walking, it would be important to compare use BWS system on treadmill and ground. Aim: To analyze healthy adults walking no harness 30% Method: Kinematics data from 14 (26 ± 3 years old) were acquired they walked treadmill. From these data, temporal-spatial parameters joint segmental angles...
Background: Partial body weight support (BWS) systems have been used with treadmills as a strategy for rehabilitation of individuals gait impairment. Considering that over ground is the commonly surface walking, it would be important to compare use BWS system on treadmill and ground. Aim: To analyze healthy adults walking no harness 30% Method: Kinematics data from 14 (26 ± 3 years old) were acquired they walked treadmill. From these data, temporal-spatial parameters joint segmental angles...
Abstract The central role of dendritic cells (DCs) in antigen presentation and induction antitumor immunity supported the development vaccines based on these cells. In previous studies, we have observed that treatment with ultra-low doses paclitaxel (PAC) modulated human DCs to express phenotype mature activated cells, stimulated their activity. At same time, tumor treated low concentrations drugs became more immunogenic susceptible lytic activity cytotoxic T lymphocytes vitro. Therefore,...
Background We have recently observed that treatment of colon tumor cells with low concentration paclitaxel increased the expression several genes associated antigen-presenting machinery. Since 5-fluoruracil (5-FU) is main antineoplastic agent for cancer, in this study we aimed to evaluate: a) whether transfection dendritic (DC) drug-treated RNA, enhances effectiveness DC-based vaccine; b) if modulatory effects vaccine can be vivo, and c) combination DC dose chemotherapy schedule improves...