Hélder Antônio Rebelo Pontes

ORCID: 0000-0002-7609-8804
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About
Contact & Profiles
Research Areas
  • Oral and Maxillofacial Pathology
  • Salivary Gland Tumors Diagnosis and Treatment
  • Bone Tumor Diagnosis and Treatments
  • Tumors and Oncological Cases
  • Viral-associated cancers and disorders
  • Lymphoma Diagnosis and Treatment
  • Sarcoma Diagnosis and Treatment
  • Ear and Head Tumors
  • Soft tissue tumor case studies
  • Oral Health Pathology and Treatment
  • Cancer Diagnosis and Treatment
  • Oral and gingival health research
  • Head and Neck Cancer Studies
  • Histiocytic Disorders and Treatments
  • Head and Neck Surgical Oncology
  • Vascular Malformations and Hemangiomas
  • Dental Radiography and Imaging
  • dental development and anomalies
  • Bone health and treatments
  • Oral health in cancer treatment
  • Dental Research and COVID-19
  • Multiple Myeloma Research and Treatments
  • Parathyroid Disorders and Treatments
  • Peptidase Inhibition and Analysis
  • Nonmelanoma Skin Cancer Studies

Universidade Estadual de Campinas (UNICAMP)
2014-2025

Universidade Federal do Pará
2016-2025

San Antonio College
2024

Universidade de São Paulo
2007-2024

Amazon (Germany)
2022

Ordem dos Médicos
2022

Hospital Universitário da Universidade de São Paulo
2019

Universidade Federal de Minas Gerais
2005-2015

Microsoft (Brazil)
2008

Fundação Faculdade de Odontologia
2008

ABSTRACT Background Rhabdomyosarcoma (RMS), a rare malignant tumor, frequently affects pediatric patients, with 35%–40% occurring in the head and neck. This study analyzes clinicopathologic profile of neck rhabdomyosarcomas from Brazil, Guatemala, Mexico, South Africa. Methods We reviewed 44 cases 10 Oral Maxillofacial Pathology services, conducting immunohistochemical analyses desmin, myogenin, Myo‐D1, Ki67, quantification via QuPath software. Cases ≥ 50% myogenin expression were tested for...

10.1111/jop.13600 article EN Journal of Oral Pathology and Medicine 2025-01-06

Understanding the early molecular events driving oral carcinogenesis is vital for diagnosing squamous cell carcinoma (OSCC) promptly. While metabolic differences between leukoplakia (OLK), OSCC, and healthy mucosa have been reported, changes distinguishing malignant transformed OLKs (MT-OLK) from non-transformed (NT-OLK) remain unexplored. Here, we examine metabolomic profiles of 5 cases MT-OLK 15 NT-OLK to identify key predictive molecules using untargeted high-performance liquid...

10.3390/ijms26051802 article EN International Journal of Molecular Sciences 2025-02-20

There is some evidence of Twist participation in oral carcinogenesis; however, little known about its interaction with E-cadherin squamous cell carcinoma (OSCC) development. This experimental study included an immunohistochemical analysis and proteins paraffin-embedded specimens leukoplakia (OL), OSCC, normal mucosa. In addition, it was also performed a Western blot double-immunofluorescence expression OSCC lines. Significant differences immunoexpression were observed between mucosa OL,...

10.1111/jop.12096 article EN Journal of Oral Pathology and Medicine 2013-06-15

Abstract: Chat generative pre-trained transformer (ChatGPT), a large language model based on the GPT-3.5 architecture, has potential to revolutionize field of medicine. As machine learning tool, ChatGPT ability analyze vast amounts medical data and provide clinicians with accurate relevant information improve patient care. One key advantages is its assist in evidence-based medicine, as it can datasets clinical trials other studies help identify most effective treatments for specific...

10.21037/jmai-23-70 article EN Journal of Medical Artificial Intelligence 2023-10-01

The aim of this study was to investigate the prevalence oral sarcomas from geographic regions Brazil.A cross-sectional conducted on biopsies obtained January 2007 December 2016 at twelve Brazilian and maxillofacial pathology centres. Gender, age, evolution time, clinical aspects, tumour location, size diagnosis, radiographic aspects histopathological diagnosis were evaluated. Data analysed using descriptive statistical methods.From 176,537, a total 200 (0.11%) reported, most prevalent...

10.1111/odi.13211 article EN Oral Diseases 2019-10-12

Odontogenic tumors (OT) are composed of heterogeneous lesions, which can be benign or malignant, with different behavior and histology. Within this classification, ameloblastoma ameloblastic carcinoma (AC) represent a diagnostic challenge in daily histopathological practice due to their similar characteristics the limitations that incisional biopsies represent. From these premises, we wanted test usefulness models based on artificial intelligence (AI) field oral maxillofacial pathology for...

10.1111/jop.13481 article EN Journal of Oral Pathology and Medicine 2023-09-15

Abstract Aim Langerhans cell histiocytosis (LCH) is an unusual proliferative disorder of bone marrow‐derived histiocytes (Langerhans cells) that can produce focal or systemic manifestations. Oral manifestations LCH present as single multiple lesions and be a challenge in clinical practice. The aim this paper to the clinicopathological features series nine patients with oral involvement. Methods results patient's age ranged from 2 63 years being five males four females. most common site...

10.1111/scd.12330 article EN Special Care in Dentistry 2018-09-12
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