Sílvia Ferreira de Sousa

ORCID: 0000-0001-7820-4749
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About
Contact & Profiles
Research Areas
  • Oral and Maxillofacial Pathology
  • Bone Tumor Diagnosis and Treatments
  • Tumors and Oncological Cases
  • Salivary Gland Tumors Diagnosis and Treatment
  • Oral Health Pathology and Treatment
  • Soft tissue tumor case studies
  • Oral and gingival health research
  • Head and Neck Cancer Studies
  • Sarcoma Diagnosis and Treatment
  • Ear and Head Tumors
  • Cancer Diagnosis and Treatment
  • Bone and Dental Protein Studies
  • Vascular Tumors and Angiosarcomas
  • Vascular Malformations and Hemangiomas
  • Cancer-related molecular mechanisms research
  • Salivary Gland Disorders and Functions
  • Oral health in cancer treatment
  • dental development and anomalies
  • Hedgehog Signaling Pathway Studies
  • Dental Radiography and Imaging
  • Lymphoma Diagnosis and Treatment
  • Cutaneous Melanoma Detection and Management
  • Dermatologic Treatments and Research
  • Viral-associated cancers and disorders
  • Neuroblastoma Research and Treatments

Universidade Federal de Minas Gerais
2016-2025

Universitat de Barcelona
2023

University of KwaZulu-Natal
2023

Hospital Pedro Hispano
2021

Universidade Federal de Sergipe
2017-2019

Hospital de Egas Moniz
2008

Universidade de São Paulo
2005

Cosmetic injections are increasing, as their complications, which can be misdiagnosed neoplastic lesions. This study aimed to detail clinical, pathological, histochemical, and immunohistochemical features of adverse reactions cosmetic fillers in the oral maxillofacial region. Samples were retrieved from five pathology laboratories. Hematoxylin-eosin (H&E), Alcian Blue, Sirius Red, Toluidine blue stains performed, well immunohistochemistry for CD68, CD3, CD20. H&E was evaluated under...

10.1111/jop.13604 article EN Journal of Oral Pathology and Medicine 2025-01-29

ABSTRACT Background Salivary glands are the reservoir for severe acute respiratory syndrome Coronavirus 2 virus (SARS‐CoV‐2). It is known that SARS‐CoV‐2 uses angiotensin‐converting enzyme (ACE2), transmembrane serine protease (TMPRSS2) and FURIN to infect cells. express these entry factors, it unclear if molecules expressed in salivary from primary Sjögren's disease (pSjD). This study assessed ACE2 , TMPRSS2 gene expression by RT‐qPCR pSjD compared normal gland pleomorphic adenoma. Methods...

10.1111/jop.13621 article EN Journal of Oral Pathology and Medicine 2025-03-17

Abstract Background The erbB receptors and their ligands are involved in the pathogenesis progression of oral squamous cell carcinoma (OSCC). Although EGFR Her-2 frequently overexpressed OSCC, few studies evaluated these proteins saliva association with tumor, which may represent potential usefulness a clinical setting. Methods levels EGFR, Her-2, EGF were 46 patients OSCC before after surgical removal lesion, as well matched healthy controls. relationship salivary immunoexpression tumor...

10.1186/1756-9966-29-40 article EN cc-by Journal of Experimental & Clinical Cancer Research 2010-04-29

The objective of this study was to evaluate lymphangiogenesis in oral squamous cell carcinoma and the associated lymph nodes podoplanin expression neoplastic cells at invasive front. In addition, association above parameters with node metastasis also investigated. We used immunohistochemistry examine primary tumors nodes, regardless metastasis. Lymphatic vessel density (LVD) microvessel (MVD) were assessed by antibodies D2-40 CD105, respectively, intratumoral peritumoral areas regions....

10.1097/pai.0b013e31824bb3ea article EN Applied immunohistochemistry & molecular morphology 2012-04-10

To compare the immunohistochemistry (IHC) expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinomas (OSCC) with gene amplification evaluated by fluorescence situ hybridization (FISH) and chromogenic (CISH) their association clinicopathological parameters. Additionally, we tested sensibility specificity CISH comparison FISH.Case series studyOral surgery pathology department a school dentistry.52 patients histopathological diagnosis OSCC.Tumour tissue samples from...

10.1136/bmjopen-2012-002077 article EN cc-by-nc BMJ Open 2013-01-01

Oral leukoplakia (OL) dysplasia is graded on the basis of architectural and cytological features, grade does not correlate well with malignant transformation. Loss heterozygosity (LOH) profiles have been validated as risk predictors OL We aimed to assess whether histological parameters used show different LOH profiles.Areas epithelial 29 samples were microdissected, was assessed by use a panel 11 microsatellite markers located chromosomes 3, 9, 11, 17. Dysplasia graded, scored. mild in 18...

10.1111/his.12746 article EN Histopathology 2015-06-03

Background Mutations previously considered drivers of malignant neoplasms also occur in benign tumors. From the biological perspective, study and is equally relevant. The rare tumors contributes to understanding more common ones, as both could share same hallmark genetic drivers. identification driver mutations facilitated by fact that they harbor quiet genomes. Pathogenic have being described epithelial odontogenic tumors, such ameloblastomas adenomatoid However, molecular pathogenesis...

10.1111/jop.12598 article EN Journal of Oral Pathology and Medicine 2017-06-09
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