A5049374968- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Vascular Malformations and Hemangiomas
- Neuroblastoma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Salivary Gland Disorders and Functions
- Cancer, Hypoxia, and Metabolism
- Cleft Lip and Palate Research
- Bone and Dental Protein Studies
- Fluoride Effects and Removal
- Infectious Diseases and Mycology
- dental development and anomalies
- Actinomycetales infections and treatment
- Oral and gingival health research
- Cancer-related gene regulation
- Head and Neck Anomalies
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Dental Health and Care Utilization
- Peptidase Inhibition and Analysis
- Vascular Tumors and Angiosarcomas
- Oral health in cancer treatment
- Protease and Inhibitor Mechanisms
Universidade Federal do Pará
2020-2025
Universidade Estadual de Campinas (UNICAMP)
2025
Abstract The aim of this study was to verify whether the expression cell proliferation and apoptosis markers in different types unicystic ameloblastoma (UA) is associated with location neoplastic cells. Immunohistochemical a sample 32 cases UA, 11 conventional (CAM) ten dental follicles (DF) performed. Cell assessed using Ki-67 status, by caspase-3 expression. Mural UA (MUA) showed higher immunostaining ( p < 0.05) lower Caspase-3 compared luminal intraluminal subtypes CAM. cells MUA’s...
ABSTRACT Objective This study aimed to assess the expression of invadopodia‐related proteins in mucoepidermoid carcinoma and their influence on this tumor's invasiveness. Material Methods Twenty‐seven grading samples were evaluated for Tks4, Tks5, cortactin, MT1‐MMP compared 10 control normal‐looking salivary glands by immunohistochemistry. For vitro analysis, immunofluorescence identified cell line. Invadopodia formation invasion assays performed after silencing Tks4 Tks5 evaluate Results...
Abstract Background Oral squamous cell carcinoma (OSCC) is the most relevant malignant neoplasm among all head and neck tumours due to its high prevalence unfavourable prognosis. Tumour invasion metastasis that affect prognosis are result of a set complex events cells with invasive potential use spread other regions. These several mechanisms invade tissues, including type finger-like membrane protrusion called invadopodia. This study aims investigate immunoexpression invaopodia...
Ameloblastoma (AMB) is a benign odontogenic tumour, with an aggressive local behaviour and high rate of recurrence. Previous studies have demonstrated that hypoxia-induced factor alpha 1 (HIF-1α) activated caspase-3 contribute to tumour invasiveness cytogenesis in ameloblastoma. Hypoxia increases HIF-1α levels, which triggers number signalling pathways. This paper aimed present data the study hypoxia-activated pathways modulate proapoptotic antiapoptotic events AMB.Twenty cases AMB ten...
Abstract Ameloblastomas are epithelial odontogenic tumours that, although benign, locally invasive and may exhibit aggressive behaviour. In the tumour microenvironment, concentration of oxygen is reduced, which leads to intratumoral hypoxia. Under hypoxia, crosstalk between HIF-1α, MMP-2, VEGF, VEGFR-2 proteins has been associated with hypoxia-induced angiogenesis, leading progression increased invasiveness. This work showcases 24 ameloblastoma cases, 10 calcifying cysts, 9 dental follicles,...
To investigate the biochemical and morphological effects of ethanol (EtOH) binge drinking during pregnancy on parotid glands (PG), submandibular (SMG), saliva offspring rats. Pregnant Wistar rats (n = 8) were exposed to EtOH consumption (3 g/kg/day – 20 % w/v) for three consecutive days. The 40-day-old was collected determine amylase activity total protein concentration. PG SMG performe oxidative biochemistry, morphometric immunohistochemistry analyses (Student's t-test, p < .05)....
Abstract Background Ameloblastoma (AME) is a benign odontogenic tumour of epithelial origin characterised by slow but aggressive growth, infiltration, and recurrence; it capable reaching large dimensions invading adjacent structures. Stem cell research has proven to be significant in the sphere biology through these cells’ possible involvement aetiopathogenesis this tumour. Methods Immunohistochemistry was performed on AME, dentigerous cyst (DC), dental follicle (DF) samples, indirect...
Actinomycosis is a rare chronic disease caused by bacterial infection of the Actinomyces genus. Standard treatment usually involves drainage and high doses antibiotic therapy, which takes between 6–12 weeks for complete resolution. A 57-year-old male was admitted with soft tissue infection-like inflammation parasymphysis region, further diagnosed as cervicofacial actinomycosis. Treatment comprised surgical debridement associated took only 4 healing. Although isn't part standard treatment, it...
Background Ameloblastoma (AME) is characterized by a locally invasive growth pattern. In an attempt to justify the aggressiveness of neoplasms, investigation role stem cells has gained prominence. The SOX-2, NANOG and OCT4 proteins are important cell biomarkers. Methodology To verify expression these in tissue samples AME, dentigerous cyst (DC) dental follicle (DF), immunohistochemistry was performed indirect immunofluorescence were on human AME (AME-hTERT) line. Results Revealed AME-hTERT...
There is currently a controversial and heated debate about the safety ethical aspects of fluoride (F) used for human consumption. Thus, this study assessed effects prenatal postnatal F exposure rats on salivary glands their offspring. Pregnant were exposed to 0, 10, or 50 mg F/L from drinking water, first day gestation until offspring weaning (42 days). The euthanized collection parotid (PA) submandibular (SM) glands, assess oxidative biochemistry perform morphometric immunohistochemical...
Abstract Background ADAMTS expression can be associated with several inflammatory processes, and has been correlated tumorigenesis of some neoplasms, but its participation in the development periapical lesions not investigated. Therefore, our objective was to verify ADAMTS-1, versican pEGFR Periapical Granuloma (PG) Radicular Cyst (RC) since they are most common periapex. Methods 25 samples RC 10 PG were used. As a control, fibrous hyperplasia (IFH) dental follicle (DF) The these proteins...
ABSTRACT The acetylation of histones H2A on lysine 5 (H2AacK5) and H3 27 (H3AcK27) modulate several cellular mechanisms through the p300 enzyme in pathological lesions; however, their role odontogenic lesions has not been addressed. This study aims to evaluate immunoexpression p300, H2AacK5, H3AcK27 samples ameloblastoma (AMB) ( n = 30), keratocyst (OK) 15), adenomatoid tumor (AOT) 10), fibroma (OF) 8), calcifying cyst (COC) myxoma (MIX) ameloblastic (AF) 06). percentage p300‐positive cells...
A glandular odontogenic cyst (GOC) has an intriguing, aggressive behaviour whose mechanisms have not yet been clarified.To conduct a collaborative cross-sectional study on the clinical, demographic, microscopic and immunohistochemical characteristics of GOCs, emphasizing histopathological expression proteins related to invasiveness.Twenty-two cases GOC from three oral maxillofacial pathology services in Brazil were selected 1988 2018. Clinical demographic data collected. Histopathological...
Despite a strong body of evidence attesting to the effectiveness fluoride (F) in preventing and controlling caries, some studies have sought investigate influence F exposure on salivary glands, organs that are essential for maintenance cavity homeostasis through production, finding can cause biochemical proteomic changes. Thus, this study aimed morphological effects prolonged glands mice, at concentrations would correspond optimally fluoridated water (suitable human consumption)...
Abstract Objectives This study aimed to assess whether the different biological behaviour between subtypes of unicystic ameloblastoma (UA) are related expression proteins that modulate cell proliferation and apoptosis. Materials methods Immunohistochemical with a sample 32 cases UA, 11 conventional (CAM) 10 dental follicles (DF) was performed. Cell assessed using Ki-67 status apoptosis by Caspase-3. Positive cells were quantified in each difference among groups compared. Results Mural UA...