A5077673587- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Endometrial and Cervical Cancer Treatments
- Head and Neck Surgical Oncology
- Cervical Cancer and HPV Research
- Advances in Oncology and Radiotherapy
- RNA modifications and cancer
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Surgical site infection prevention
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
- Cancer survivorship and care
- Salivary Gland Tumors Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
Hospital de Câncer de Barretos
2012-2024
Dana-Farber Brigham Cancer Center
2023
Brigham and Women's Hospital
2023
Dana-Farber Cancer Institute
2023
University of California, Los Angeles
2023
Hospital São Paulo
2023
AC Camargo Hospital
2006-2008
Abstract Head and neck cancer (HNC) patients suffer from a range of health‐related quality life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group HRQoL at least 5 years' post‐diagnosis in HNC survivors. In an international cross‐sectional study, survivors completed the European Organization for Research Treatment Cancer (EORTC) core questionnaire (EORTC‐QLQ‐C30) its module (EORTC‐QLQ‐H&N35). Meaningful differences...
The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the quality life in this population, 1114 HNCS were asked to state their two most serious effects. A clinician recorded responses during face-to-face appointments. list 15 example was provided, but free text field also available. total 1033 responded question. frequent 'dry mouth' (DM) (n = 476; 46%), 'difficulty swallowing/eating' (DSE) 408; 40%),...
TP53 is the most frequently mutated gene in lung tumors, but its prognostic role admixed populations, such as Brazilians, remains unclear. In this study, we aimed to evaluate frequency and clinicopathological impact of mutations non-small cell cancer (NSCLC) patients Brazil.We analyzed 446 NSCLC from Barretos Cancer Hospital. mutational status was evaluated through targeted next-generation sequencing (NGS) variants were biologically classified disruptive/nondisruptive...
The evolution of radiotherapy over recent decades has reintroduced the hypofractionation for many tumor sites with similar outcomes to those conventional fractionated radiotherapy. use in locally advanced head and neck cancer (LAHNC) been already used, however, its restricted only a few countries. aim this trial was evaluate safety feasibility moderate hypofractionated (HYP-RT) concomitant cisplatin (CDDP). This single-arm designed HYP-RT CDDP LAHNC. Stage III IV patients withnonmetastatic...
Head and neck squamous cell carcinoma (HNSCC) is well known as a serious health problem worldwide, especially in low-income countries or those with limited resources, such most Latin America. International guidelines cannot always be applied to population from large region specific conditions. This study established American guideline for care of patients head cancer presented evidence HNSCC management considering availability oncologic benefit. A panel composed 41 experts systematically...
Abstract Introduction Lung cancer in never-smoker (LCINS) patients accounts for 20% of lung cases, and its biology remains poorly understood, particularly genetically admixed populations. We elucidated the molecular profile driver genes Brazilian LCINS. Methods The mutational gene fusion status 119 adenocarcinomas from self-reported patients, was assessed using targeted sequencing (NGS), nCounter, immunohistochemistry. A panel 46 ancestry-informative markers determined patients’ genetic...
To report our experience treating soft tissue sarcoma (STS) with high dose rate brachytherapy alone (HBRT) or in combination external beam radiotherapy (EBRT) pediatric patients.Eighteen patients, median age 11 years (range 2 - 16 years) grade 2-3 STS were treated HBRT using Ir-192 a interstitial (n = 14) intracavitary implant 4). Eight patients alone; the remaining 10 of and EBRT.After follow-up 79.5 months 12 159), 14 alive without evidence disease (5-year overall survival 84.5%). There no...
Purpose: To report the outcomes and toxicity of high dose rate brachytherapy as a boost for localized prostate cancer. Materials Methods: Between 1997 2000, medical records 131 patients with adenocarcinoma who were treated external beam radiation therapy brachytherapy, retrospectively analyzed. Furthermore, 55% received neoadjuvant/concurrent or adjuvant androgen deprivation therapy. Patients stratified into 2 groups. Group 1 included 65 Gleason score 7, pretreatment specific antigen (PSA)...
The purpose of this phase II trial was to evaluate the tolerability, safety, and efficacy a non-5-fluorouracil (5-FU)-based induction chemotherapy followed by chemoradiotherapy (CRT) for patients with locally advanced head neck squamous cell carcinoma (HNSCC).Sixty stage III IV HNSCC were treated paclitaxel cisplatin (TP; 175 mg/m(2) 80 , 3 cycles) CRT (cisplatin 100 ; D1, 22, 43 radiotherapy).Fifty-six (93.3%) completed cycles TP (no treatment-related deaths), 52 (86.7%) definitive per...
NTRK1, 2, and 3 fusions are important therapeutic targets for NSCLC patients, but their prevalence in South American admixed populations needs to be better explored. NTRK fusion detection small biopsies is a challenge, distinct methodologies used, such as RNA-based next-generation sequencing (NGS), immunohistochemistry, nCounter. This study aimed evaluate the frequency concordance of positive samples using custom nCounter assay real-world scenario single institution Brazil. Out 147 12 (8.2%)...
Pelvic Radiotherapy (RT) as a postoperative treatment for endometrial cancer improves local regional control. Brachytherapy also vaginal Both treatments imply significant side effects that fine RT technique can help avoiding. Intensity Modulated (IMRT) enables the of target volume while protecting normal tissue. It therefore reduces incidence and severity effects. We report on 50 year-old patient with serous-papiliferous adenocarcinoma uterus who was submitted to surgical without lymph node...
Abstract ERBB2 exon 20 insertions may impact the clinical management of lung cancer patients. However, frequency in patients Brazil is scarce. Here, we analyzed 722 Brazilian non‐small cell (NSCLC) from Barretos Cancer Hospital that were indicated to require routine molecular testing. evaluated by a targeted panel using next‐generation sequencing (NGS). Clinicopathological and data collected patient medical records. Among NSCLC patients, 85.2% had adenocarcinomas, 53.9% male, 66.8% quitter...
To evaluate the results of salvage conformal radiation therapy (3DC-EBRT) for patients submitted to radical prostatectomy (RP) who have achieved complete PSA response and never been treated with hormonal (HT).To present biochemical control, a period free from factors related its prognosis.from August 2002 December 2004, 43 prostate cancer RP presented failure after achieving < 0.2 ng/ml. They received HT were 3DC-EBRT. Median age was 62 years, median preoperative 8.8 ng/ml, Gleason Score 7....
Abstract Background Targeted and immunotherapies are currently moving toward early-stage settings for patients with non-small cell lung cancer (NSCLC). Predictive biomarkers data scarce in this scenario. We aimed to describe the frequency of EGFR mutations PD-L1 expression levels non-squamous NSCLC from a large, single Brazilian oncology center. Methods retrospectively evaluated diagnosed at an (IB IIIA-AJCC seventh edition) Barretos Cancer Hospital (n = 302). mutational status was assessed...
To evaluate the pathologic response of cervical carcinoma to external beam radiotherapy (EBRT) and high dose rate brachytherapy (HDRB) outcome.Between 1992 2001, 67 patients with were submitted preoperative radiotherapy. Sixty-five stage IIb. Preoperative treatment included 45 Gy EBRT 12 HDRB. Patients surgery after a mean time 82 days. Lymphadenectomy was performed in 81% patients. Eleven residual cervix disease on pathological specimen 2 additional insertions HDRB.median follow up 72...
The nuclear factor κ B (NF-κB) family comprises transcription factors that promote the development and progression of cancer. NF-κB pathway is induced by radiation therapy may be related to tumour radioresistance. aim this study was evaluate expression as a predictor response radiotherapy its value prognostic marker.A retrospective analysis performed in series 32 individuals with stage IB2 IIB cervical cancer who underwent radiotherapy, followed radical hysterectomy, from January 1992 June...
To provide an overview of the achievements and future research with stereotactic body radiotherapy (SBRT) in prostate cancer.SBRT publications for cancer were retrieved from Web Science Dimension database. Bibliometric analyses performed using VOSviewer Prism graph. Analysis variance test was used to compare publication, citation, mean citation between specialty journals. Network maps produced identify authors' countries' collaboration clusters.Between 2006 2020, 574 fulfilling inclusion...
OBJETIVO: Reportar resultados de tratamentos do câncer próstata com radioterapia conformada 3D realizados em uma única instituição. MATERIAIS E MÉTODOS: De julho 1997 a janeiro 2002, 285 pacientes consecutivos foram submetidos dose mediana 7.920 cGy na e analisados retrospectivamente. A distribuição segundo o grupo risco foi seguinte: baixo - 95 (33,7%); intermediário 66 (23,4%); alto 121 (42,9%) pacientes. RESULTADOS: Em seguimento mediano 53,6 meses (3,6-95,3 meses), sobrevidas atuariais...