A5004115272- Colorectal Cancer Screening and Detection
- Palliative Care and End-of-Life Issues
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Childhood Cancer Survivors' Quality of Life
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Healthcare professionals’ stress and burnout
- Palliative and Oncologic Care
- Patient Dignity and Privacy
- Lung Cancer Treatments and Mutations
- Air Quality and Health Impacts
- Patient-Provider Communication in Healthcare
- Cancer survivorship and care
- Nonmelanoma Skin Cancer Studies
- Psychological Well-being and Life Satisfaction
- Oral Health Pathology and Treatment
- Testicular diseases and treatments
- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Cutaneous lymphoproliferative disorders research
- Fish biology, ecology, and behavior
- Geography and Environmental Studies
Hospital de Câncer de Barretos
2017-2024
Hospital São Paulo
2019-2023
Weatherford College
2021
Fundação Oswaldo Cruz
2020
Santa Casa de Misericórdia de Passos
2020
AC Camargo Hospital
2016-2018
Universidade de Uberaba
2015
Instituto do Coração
2015
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015
Universidade do Vale do Paraíba
2011
To evaluate the prevalence and possible factors associated with development of burnout among medical students in first years undergraduate school.A cross-sectional study was conducted at Barretos School Health Sciences, Dr. Paulo Prata. A total 330 four school were invited to participate responding sociodemographic Maslach Burnout Inventory-Student Survey (MBI-SS) questionnaires. The first-year group consisted 150 students, followed by second-, third-, fourth-year groups, 60 each.Data from...
Microbial diversity has been pointed as a major factor in the development and progression of colorectal cancer (CRC). We sought to explore richness abundance microbial community series tumor samples treated at Barretos Cancer Hospital, Brazil, through 16S rRNA sequencing. The presence impact Fusobacterium nucleatum (Fn) DNA CRC prognosis was further evaluated by qPCR 152 cases. An enrichment for potentially oncogenic bacteria observed, with being most abundant genus tissue. In validation...
Colorectal cancer is the second most common in Brazil. Yet, a nationally organized colorectal screening program not implemented. Barretos Cancer Hospital (BCH) one of largest Brazilian institution that cares for underserved patients. BCH developed fecal immunochemical test (FIT)-based to improve outcomes.This study aims present quality/performance measures first 2 years FIT-based and its impact on disease stage. Between 2015 2017, total 6,737 individuals attending Outpatient Department...
Colorectal cancer (CRC) is a leading cause of death worldwide. Microsatellite instability (MSI) genetic pathway to CRC, associated with particular clinicopathological features, and recently major biomarker immunotherapy response. There little information the frequency MSI among Brazilian CRC patients, it still debatable ideal methodology for screening in countries limited resources. We proposed evaluate by molecular immunohistochemistry (IHC) methods, compare both methodologies also assess...
Abstract Lung cancer is the deadliest worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity smoking. impact mutations Brazilian remains poorly explored. Thus, we investigated a large series together with patients’ genetic ancestry, clinicopathological sociodemographic characteristics. was 22.7% 20.4%. average ancestry proportions were 73.1% for EUR, 13.1% AFR, 6.5% AME 7.3% ASN. independently associated never-smokers, high-Asian...
Abstract The molecular basis of colorectal cancer (CRC) can guide patient prognosis and therapy. In Brazil, knowledge on the CRC mutation landscape is limited. Here, we investigated profile 150 cancer-related genes by next-generation sequencing associated with microsatellite instability (MSI) genetic ancestry in a series 91 Brazilian patients. Driver mutations were found APC (71.4%), TP53 (56.0%), KRAS (52.7%), PIK3CA (15.4%) FBXW7 (10.9%) genes. Overall, MAPK/ERK, PIK3/AKT, NOTCH receptor...
Colorectal cancer (CRC) screening can help to reduce its incidence and mortality. Noninvasive strategies, such as plasma analysis of epigenetic alterations, constitute important biomarkers CRC detection.This study aimed evaluate the methylation status SEPT9 BMP3 promoters for detection precursor lesions in a Brazilian population.Plasma samples from 262 participants program Barretos Cancer Hospital who had positive fecal occult blood test underwent colonoscopy patients were analyzed....
Objetivo: avaliar os índices de acidentes ocupacionais dos garis, identificar fatores riscos relacionados aos trabalho e a frequência o motivo da procura do serviço público saúde pelo gari. Método: trata-se uma pesquisa descritiva, realizada no município Picos/PI. A população amostra foi representada por 51 coletores lixo. Os dados foram coletados meio um formulário, período setembro novembro 2019 digitados com utilização software. Resultados: maioria relatou ter sofrido menos tipo acidente...
Patients with refractory colorectal (CRC) cancer have few treatment options. This trial tests the combination of metformin and irinotecan in this setting.A phase 2 single-arm was conducted, patients received 2500 mg orally a day plus 125 mg/m2 intravenously weekly D1 D8 every 21 days. The primary endpoint disease control rate according to Response Evaluation Criteria Solid Tumors version 1.1 at 12 weeks.Between December 2015 January 2018, 41 were enrolled. Seventeen (41%) met weeks; hence,...
To evaluate the preferred place-of-death (PPoD) among patients with advanced cancer over time, and concordance between actual place-of-death.Prospective cohort study. A total of 190 their caregivers (n=190) were interviewed every 3 months, from study enrolment to 12 months (M0, M1, M2, M3, M4). PPoD data obtained under four different end-of-life scenarios: (1) severe clinical deterioration without further specification; (2) suffering symptoms; (3) receiving home-based visits; (4) visits...
Medulloblastoma is the most frequent malignant brain tumor in children. Four medulloblastoma molecular subgroups, MB SHH , WNT GRP3 and GRP4 have been identified by integrated high‐throughput platforms. Recently, a 22‐gene panel NanoString‐based assay was developed for subgrouping, but robustness of this has not widely evaluated. Mutations gene human telomerase reverse transcriptase (h TERT ) found medulloblastomas are associated with distinct subtypes. This study aimed to implement...
Abstract Objectives To identify the patients who are most likely to participate in discussions about palliative care (PC) and advance planning (ACP), determine their preferred timing approach of discussion. Methods The study included women aged 18–75 years diagnosed with breast cancer. In quantitative phase, sociodemographic clinical characteristics, knowledge, decision-making, stigmas were evaluated. qualitative phase questions patients’ understanding, timing, method discussing PC ACP,...
Background: Colorectal cancer (CRC) is the third most frequent and second deadliest worldwide. The ethnic structure of population has been gaining prominence as a player. purpose this study was to determine genetic ancestry Brazilian CRC patients. Moreover, we intended interrogate its impact on patients' clinicopathological features. Methods: Retrospective observational cohort with 1,002 patients admitted from 2000 2014 at Barretos Cancer Hospital. Following tumor DNA isolation, assessed...
Methylation levels in tumor-suppressor genes and repetitive sequences have previously been used to study the relationship between environmental air pollution epigenetic changes related cancer. In this study, we measured methylation profiles of promoter regions CDKN2A, MLH1 APC sequence LINE-1 59 workers exposed construction environment 49 unexposed workers. We also evaluated micronuclei frequency trace elements blood all particulate matter polycyclic aromatic hydrocarbons (PAHs) at site...
Abstract Background Although cancer patients experience distressing symptoms and health-related changes in their quality of life, they may report positive emotional states. The lives informal caregivers also be affected by the patient’s diagnosis; however, find benefits experiences. Noticeable are reported personal priorities after an oncologic diagnosis that can lead individuals to restructure values way perceive life. This study aims assess happiness/satisfaction with life negative affect...
The therapeutic approach to Wilms tumor (WT) is multidisciplinary and leads significant patient impairment, increasing the risk of nutritional compromise malnutrition. Children with cancer are vulnerable sarcopenia which has been recognized as a negative impact anticancer therapy. Recent studies have highlighted reduction in total psoas muscle area (TPMA) be associated poor prognosis many pediatric diseases, including cancer. This study aims evaluate changes TPMA compartment during treatment...
Neoadjuvant chemotherapy (NACT) is the mainstay of treatment stages II and III triple-negative breast cancer (TNBC). This study aims to evaluate if addition carboplatin NACT associated with an increase in pathological complete response (pCR) rates TNBC.We conducted open-label phase randomized clinical trial a single center Brazil. Patients stage TNBC were receive standard or without carboplatin. All patients received doxorubicin (60 mg/m2) plus cyclophosphamide (600 both intravenously (i.v.)...
Abstract Background: Tobacco or human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) represent different clinical and epidemiologic entities. This study investigated the prevalence of HPV-positive HPV-negative OPSCC in a reference cancer hospital Brazil its association with demographic data, as well impact on overall survival. Methods: HPV infection was determined by p16-IHC pre-treatment formalin-fixed paraffin-embedded samples from all patients diagnosed at...