A5019299186- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Advanced Radiotherapy Techniques
- Dysphagia Assessment and Management
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Soft tissue tumor case studies
- Cancer survivorship and care
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Patient Satisfaction in Healthcare
- Voice and Speech Disorders
- Nosocomial Infections in ICU
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Genetic and Kidney Cyst Diseases
- Pleural and Pulmonary Diseases
- Cancer-related Molecular Pathways
- Nutrition and Health in Aging
- Cytomegalovirus and herpesvirus research
Institut Jules Bordet
2016-2025
University of Lausanne
2025
Université Libre de Bruxelles
2019-2025
Regional Cancer Center, Thiruvananthapuram
2019
University of Alberta
2015
Abstract Head and neck cancer (HNC) patients suffer from a range of health‐related quality life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group HRQoL at least 5 years' post‐diagnosis in HNC survivors. In an international cross‐sectional study, survivors completed the European Organization for Research Treatment Cancer (EORTC) core questionnaire (EORTC‐QLQ‐C30) its module (EORTC‐QLQ‐H&N35). Meaningful differences...
Highlights•The epidemiology and outcomes of intensive care unit-acquired Gram-negative bacteremia are described.•Resistance to ciprofloxacin piperacillin/tazobactam was common.•Carbapenem resistance among pseudomonal isolates surprisingly high.•Most patients received adequate empiric antimicrobial therapy.•Coronary disease, immunosuppression, therapy predicted mortality.SummaryObjectivesTo describe the epidemiology, susceptibilities, treatment, unit (ICU)-acquired bacteremia.MethodsPatients...
The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the quality life in this population, 1114 HNCS were asked to state their two most serious effects. A clinician recorded responses during face-to-face appointments. list 15 example was provided, but free text field also available. total 1033 responded question. frequent 'dry mouth' (DM) (n = 476; 46%), 'difficulty swallowing/eating' (DSE) 408; 40%),...
Using patient reported-outcome measures (PROMs) in routine care has significant potential to benefit patients with cancer, but it is unclear how widely they are used practice. We conducted a cross-sectional survey (November 2023-April 2024) among healthcare professionals (HCPs) the European Organisation for Research and Treatment of Cancer (EORTC). Descriptive statistics chi-square tests assessed PROM use patterns, regional differences, barriers. Binary regression models compared barriers...
Abstract Background Radiation‐associated‐dysphagia is a serious side effect of radiotherapy (RT) for head and neck cancer (HNC). Methods Seventy‐six patients had weekly prospective follow‐up from baseline until one week post‐RT. Combined mixed model analysis ( n = 43) determined the evolution self‐perceived swallowing function, isometric tongue strength (MIP), (TS) during (Pswal), quality life (QoL) in these RT. Results Swallowing deteriorated third on, resulting an increase tube dependency...
Abstract Assignment of CMV infection status in infants awaiting SOT is challenging as passive maternal antibody can lead to false‐positive serology. Since 2000, our protocol has recommended sending throat and urine samples for viral detection, culture, or NAAT, CMV‐seropositive <18 months SOT. We reviewed pretransplant serology 152 and, seropositives, examined relationships between IgG OD values, age, detection explore time clearance evaluate assignment status. The proportion decreased...
Abstract Background Nutritional complications in patients with locally advanced head and neck cancer (LA-HNC) treated by concurrent chemoradiotherapy (CCRT) often lead to placement of a prophylactic gastrostomy (PG) tube, while indication lacks harmonization. Our aim was explore the current PG tube utilization among Belgian radiation oncology centers. Methods A survey distributed all 24 Radiation departments, questions about number patient per year, whether is discussed at multidisciplinary...
Percutaneous endoscopic gastrostomy (PEG) is often used to provide nutritional support in locally advanced head and neck cancer patients undergoing multimodality treatment. However, there little published data on the impact of prophylactic versus reactive PEG. PEG placement may affect swallowing-related physiology, function, quality life. The Swall study a randomized controlled phase III trial testing patient-reported outcomes terms swallowing life oropharyngeal patients.Patients with...
Definitive chemoradiotherapy (CRT) is a cornerstone of treatment for locoregionally advanced head and neck cancer (HNC). Research ongoing on how to improve the tumor response limit normal tissue toxicity. A major limitation in that regard growing number intrinsic or acquired resistance cases. In this review, we will discuss overexpression efflux pumps, perturbation apoptosis-related factors, increased expression antioxidants, glucose metabolism, metallotheionein expression, DNA repair, stem...
<title>Abstract</title> <underline>Background</underline><underline><bold>:</bold></underline> Head and Neck Squamous Cell Carcinoma (HNSCC) remains a significant global cause of mortality, with late-stage diagnoses contributing to unfavorable prognosis<sup>1</sup>. Radiotherapy (RT) is crucial in HNSCC treatment but poses risks, including osteoradionecrosis the jaw (ORNJ) dental issues post-irradiation<sup>2</sup>. Pre-RT restoration recommended, yet some patients undergo unnecessary tooth...
This study evaluates the benefit of weekly delineation and peer review by a multidisciplinary team (MDT) radiation oncologists (ROs), radiologists (RXs), nuclear medicine (NM) physicians in defining primary lymph node tumor volumes (GTVp GTVn) for head neck cancer (HNC) radiotherapy. includes 30 consecutive HNC patients referred definitive curative (chemo)-radiotherapy. Imaging data including MRI, [18F]-FDG-PET CT scan were evaluated MDT. The RO identified 'undeniable' as GTVp_core...
Abstract Background: Nutritional complications in patients with locally advanced head and neck cancer (LA-HNC) treated by concurrent chemoradiotherapy (CCRT) often lead to placement of a prophylactic gastrostomy (PG) tube, while indication lacks harmonization. Our aim was explore the current PG tube utilization among Belgian radiation oncology centers. Methods: A survey distributed all 24 Radiation departments, questions about number patient per year, whether is discussed at...