Dirk Van Gestel

ORCID: 0000-0003-4869-9319
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About
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Research Areas
  • Advanced Radiotherapy Techniques
  • Head and Neck Cancer Studies
  • Radiomics and Machine Learning in Medical Imaging
  • Medical Imaging Techniques and Applications
  • Lung Cancer Diagnosis and Treatment
  • Cancer Immunotherapy and Biomarkers
  • Oral health in cancer treatment
  • Advances in Oncology and Radiotherapy
  • Cancer Diagnosis and Treatment
  • Head and Neck Surgical Oncology
  • Cancer Genomics and Diagnostics
  • Radiation Therapy and Dosimetry
  • Pancreatic and Hepatic Oncology Research
  • Brain Metastases and Treatment
  • Dysphagia Assessment and Management
  • Prostate Cancer Diagnosis and Treatment
  • Prostate Cancer Treatment and Research
  • Management of metastatic bone disease
  • Lung Cancer Research Studies
  • Cancer Cells and Metastasis
  • Salivary Gland Tumors Diagnosis and Treatment
  • Cutaneous Melanoma Detection and Management
  • Breast Cancer Treatment Studies
  • Cancer Research and Treatments
  • Sarcoma Diagnosis and Treatment

Université Libre de Bruxelles
2015-2025

Institut Jules Bordet
2015-2024

Centre Hospitalier Universitaire Ibn Rochd
2020

Andre Abrasive Articles (Poland)
2019

University of Antwerp
2011-2018

Antwerp University Hospital
2012-2018

Taipei Medical University Hospital
2017

Centre Eugène Marquis
2017

Ziekenhuisnetwerk Antwerpen Stuivenberg
2011-2013

ZNA Middelheim Hospital
2007

Importance Although immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and PD-1 ligand have improved the outcome for many cancer types, majority of patients fails to respond ICI monotherapy. Hypofractionated radiotherapy has potential improve therapeutic ratio ICIs. Objective To assess addition ICIs compared with monotherapy in advanced solid tumors. Design, Setting, Participants This open-label, multicenter, randomized phase 2 trial was conducted 5 Belgian...

10.1001/jamaoncol.2023.2132 article EN JAMA Oncology 2023-07-06

Abstract Background Compared to static beam Intensity-Modulated Radiation Therapy (IMRT), the main advantage of Volumetric Modulated Arc (VMAT) is a shortened delivery time, which leads improved patient comfort and possibly smaller intra-fraction movements. This study aims at treatment planner-independent comparison radiotherapy planning IMRT VMAT for head-and-neck cancer performed by several institutes based on same CT- contouring data. Methods Five generated plans five oropharyngeal...

10.1186/1748-717x-8-26 article EN cc-by Radiation Oncology 2013-01-31

Radiotherapy techniques have evolved rapidly over the last decade with introduction of Intensity Modulated RadioTherapy (IMRT) in different forms. It is not clear which IMRT superior treatment head and neck cancer patients terms coverage planning target volumes (PTVs), sparing organs at risk (OARs), dose to normal tissue, number monitor units needed delivery time.The present paper aims compare Step Shoot (SS) IMRT, Sliding Window (SW) RapidArc (RA) planned Eclipse, Elekta VMAT SmartArc (SA)...

10.1186/1748-717x-8-37 article EN cc-by Radiation Oncology 2013-02-20

Abstract Background MR‐guided radiotherapy (MRgRT) offers new opportunities but also introduces workflow complexities requiring dedicated optimization. Implementing magnetic resonance linear accelerator (MR‐Linac) technology comes with challenges such as prolonged treatment times and integration issues. Purpose We present here our experience share practical tips tricks to streamline MR‐Linac implementation, optimize efficiency, improve coordination. Methods The first 150 patients treated a...

10.1002/acm2.70073 article EN cc-by Journal of Applied Clinical Medical Physics 2025-03-16

ABSTRACT Background This study aimed at identifying acoustic features of airway protective maneuvers as biomarkers radiation‐associated dysphagia, involving penetration/aspiration and pharyngeal residue. Methods Temporal spectral acoustical analyses were carried out on voluntary coughs, throat clearings, reflexive coughs. Head neck cancer patients with without compared. The same was done for healthy controls. Results A decreased convexity the amplitude contour salience periodicity in...

10.1002/hed.28163 article EN cc-by-nc Head & Neck 2025-04-16

Abstract Background Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive (BC) subtypes. Pathological complete response (pCR) rate, however, lower luminal B BC comparison to the triple negative (TNBC) HER2+ The addition of immune checkpoint blockade (ICB) NACT has potential increase pCR rate but hampered by immunogenicity BC. Novel strategies are needed stimulate ICB Methods Neo-CheckRay trial randomized phase II...

10.1186/s12885-021-08601-1 article EN cc-by BMC Cancer 2021-08-06
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