A5000239148- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cardiac tumors and thrombi
- CAR-T cell therapy research
- Uterine Myomas and Treatments
- Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cutaneous Melanoma Detection and Management
- Molecular Biology Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Musculoskeletal synovial abnormalities and treatments
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Gastrointestinal Tumor Research and Treatment
- Telemedicine and Telehealth Implementation
- Histone Deacetylase Inhibitors Research
- Renal cell carcinoma treatment
- MRI in cancer diagnosis
Institute of Cancer Research
2020-2024
Royal Marsden NHS Foundation Trust
2022-2024
National Health Service
2022
Royal Marsden Hospital
2020
PURPOSE Many patients with cancer, often those rare cancers such as sarcomas, travel long distances to access expert care. The COVID-19 pandemic necessitated widespread changes in delivery of cancer care, including rapid adoption telemedicine-based We aimed evaluate the impact telemedicine on patients, clinicians, and care at Royal Marsden Hospital (RMH) Sarcoma Unit during pandemic. METHODS Data were extracted from patient records for all planned outpatient appointments RMH March 23 April...
Abstract Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological subtypes. Within leiomyosarcomas, identify three subtypes distinct myogenesis immune features, anatomical site distribution survival outcomes. Characterisation undifferentiated pleomorphic dedifferentiated liposarcomas low infiltrating CD3 + T-lymphocyte levels...
Soft tissue sarcomas (STS) are a group of rare and heterogeneous cancers. While large-scale genomic epigenomic profiling STS have been undertaken, proteomic analysis has thus far limited. Here we utilise sequential window acquisition all theoretical fragment ion spectra mass spectrometry (SWATH-MS) for formalin fixed paraffin embedded (FFPE) specimens from cohort patients (n = 36) across four histological subtypes (leiomyosarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma...
Abstract Background Adolescents and young adult (AYA) patients with soft tissue tumours including sarcomas are an underserved group disparities in treatment outcomes. Methods To define the molecular features between AYA older (OA) patients, we analysed proteomic profiles of a large cohort across 10 histological subtypes (AYA n = 66, OA 243), also publicly available functional genomic data from tumour cell lines 5, 8). Results Biological hallmarks analysis demonstrates that significantly...
High-risk soft tissue sarcomas of the extremities and trunk wall (eSTS), as defined by Sarculator nomogram, are more likely to benefit from (neo)adjuvant anthracycline-based therapy compared low/intermediate-risk patients. The biology underpinning these differential treatment outcomes remain unknown. We analysed proteomic profiles clinical 123 eSTS A Cox model for overall survival including was fitted individual data define four risk groups. DNA replication protein signature-Sarcoma...
Background Size-based assessments are inaccurate indicators of tumor response in soft-tissue sarcoma (STS), motivating the requirement for new imaging biomarkers this rare and heterogeneous disease. In study, we assess test–retest repeatability radiomic features from MR diffusion-weighted (DWI) derived maps apparent diffusion coefficient (ADC) retroperitoneal STS compare baseline with changes following radiotherapy (RT). Materials Methods Thirty patients received an examination prior to...
Intravenous leiomyomatosis (IVLM) is a rare benign smooth muscle tumour that characterised by intravenous growth in the uterine and pelvic veins. Previous DNA copy number transcriptomic studies have shown IVLM harbors unique genomic alterations when compared to leiomyoma (uLM), which may account for their distinct clinical behaviour. Here we undertake first comparative proteomic analysis of other tumours (comprising uLM, soft tissue metastasizing leiomyoma) utilising data-independent...
<title>Abstract</title> Background Intratumoral heterogeneity means single site tumor biopsy might not be representative, leading to erroneous conclusions about biology and therapy selection. Here we develop optimize an MRI-informed multiregional technique in retroperitoneal pelvic sarcomas (RPS). Methods Participants with suspected RPS underwent multiparametric (mp)MRI within a week prior biopsy. Three ‘target regions’ differing imaging characteristics were contoured. Robotic or freehand...
Abstract Intravenous leiomyomatosis (IVLM) is a rare benign smooth muscle tumour that characterised by intravenous growth in the uterine and pelvic veins. Previous DNA copy number transcriptomic studies have shown IVLM harbours unique genomic alterations when compared to leiomyoma (uLM), which may account for their distinct clinical behaviour. Here we undertake first comparative proteomic analysis of other tumours (comprising uLM, soft tissue metastasising leiomyoma) utilising...
Synovial sarcoma is a rare translocation-driven cancer with poor survival outcomes, particularly in the advanced setting. Previous synovial preclinical studies have relied on small panel of cell lines which suffer from limitation genomic and phenotypic drift as result being grown culture for decades. Patient-derived xenografts (PDX) are valuable tool research they retain many histopathological features their originating human tumour; however, this approach expensive, slow, resource...
Monitoring treatment response of soft-tissue sarcomas (STS) following radiotherapy is challenging due to the inherent intratumoral heterogeneity disease. Radiomics and deep-learning provide opportunities for discovery potent biomarkers response. Successful must demonstrate good baseline repeatability if they are be used personalized treatment. We explore stability radiomic features derived from a pipeline by determining pairwise correlation features, measuring Apparent Diffusion-Coefficient...
Abstract Adolescents and young adult (AYA) patients with soft tissue tumours (STT) including sarcomas are an underserved group disparities in treatment outcomes. To define the molecular features between AYA older (OA) patients, we analysed proteomic profiles of a large cohort STT across 10 histological subtypes (AYA n=66, OA n=243). enriched proteins involved mitochondrial metabolism while have elevated inflammatory cell cycle signalling. By integrating patient-level data functional genomic...
Abstract Background High-risk soft tissue sarcomas of the extremities and trunk wall (eSTS), as defined by Sarculator nomogram, are more likely to benefit from (neo)adjuvant anthracycline-based therapy compared low/intermediate-risk patients. The biology underpinning these differential treatment outcomes remain unknown. Methods We analysed proteomic profiles clinical 123 eSTS A Cox model for overall survival including was fitted individual data define 4 risk groups. DNA replication protein...