A5070091094- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Cardiac tumors and thrombi
- Colorectal Cancer Treatments and Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- TGF-β signaling in diseases
- Vascular Tumors and Angiosarcomas
- Genetic and Kidney Cyst Diseases
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
Institute of Cancer Research
2021-2024
Cancer Hospital and Research Institute
2022-2023
Sri Shankara Cancer Hospital and Research Center
2022-2023
St. John's National Academy of Health Sciences
2022
St.John's Medical College Hospital
2018-2020
Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy 1,2 . This mediated in part by complex tumour microenvironment 3 , low vascularity 4 and metabolic aberrations 5,6 Although altered metabolism drives progression, the spectrum of metabolites used as nutrients PDA remains largely unknown. Here we identified uridine fuel for glucose-deprived conditions assessing how more than 175 impacted activity 21 pancreatic cell lines under nutrient...
Abstract Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological subtypes. Within leiomyosarcomas, identify three subtypes distinct myogenesis immune features, anatomical site distribution survival outcomes. Characterisation undifferentiated pleomorphic dedifferentiated liposarcomas low infiltrating CD3 + T-lymphocyte levels...
RAF kinases are highly conserved serine/threonine kinases, and among the three isoforms (ARAF, BRAF, CRAF), pathophysiological relevance of ARAF is not well defined. Here, we show that patients with lung cancer exhibit low expression ARAF, which associated lymph node metastasis poor patient survival. We uncover depletion promotes anchorage-independent growth through activation AKT signaling in a subset cells. identified loss was an increase ERBB3 kinase-independent manner. suppressed...
Abstract Background Adolescents and young adult (AYA) patients with soft tissue tumours including sarcomas are an underserved group disparities in treatment outcomes. Methods To define the molecular features between AYA older (OA) patients, we analysed proteomic profiles of a large cohort across 10 histological subtypes (AYA n = 66, OA 243), also publicly available functional genomic data from tumour cell lines 5, 8). Results Biological hallmarks analysis demonstrates that significantly...
Abstract Immunotherapy has shown limited success in pancreatic adenocarcinoma (PDAC) patients. To improve clinical management of cancer, it is crucial to identify alternative immunostimulatory targets associated with mechanisms tumor evolution facilitate the development novel combination immunotherapies. Here we categorized PDACs and other cancers (n>7,500) into subgroups based on glucocorticoid-induced necrosis factor receptor (TNFR)-related ligand (GITRL) (GITR) expression: GITRL high +...
Triple-negative breast cancer (TNBC) is a heterogeneous disease with significant challenge to effectively manage in the clinic worldwide. Immunotherapy may be beneficial TNBC patients if responders can identified. Here we sought elucidate immune landscape of TNBCs by stratifying into immune-specific subtypes (immunotypes) decipher molecular and cellular presentations signaling events this associating them their clinical outcomes potential treatment options.
Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with 5-year survival rate of 12% in the USA. PDA highly rely on glucose but surrounded by nutrient-limited microenvironment. How survive such condition, and metabolites enabling that process, unclear. To determine how adapt to starvation, we profiled utility >175 21 pancreatic cell lines cultured limited condition. This nutrient profiling assay revealed use uridine when depleted. Uridine utilization strongly...
Background Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose This study aimed explore responses of podocytes nephrotic plasma identify specific genes signaling pathways differentiating various NS groups as well biological processes that drive injury normal podocytes. Methods Transcriptome profiles...
Abstract Background Breast Cancer (BC) patients who do not obtain pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) present higher rate of relapse and worse overall survival. Recent evidence suggests that (CT) efficacy relies on the capacity chemotherapeutic agents to interact with immune system. BC features a unique tumor microenvironment (TME) comprising multiple cell types including Macrophages share double-edged relationship cancer as they get polarised from M1...
Abstract Introduction: Triple-Negative Breast Cancer (TNBC) comprises approximately 30% of all breast cancers in Indian women. Given their aggressive nature, TNBCs have high rates systemic metastasis and mortality with only chemotherapy available for treatment. Compelling evidence has demonstrated the prognostic value tumor-infiltrating lymphocytes (TILs), many especially play a critical role tumour progression, response to therapeutics prognosis. They are typically measured by H&E...
Abstract Background: Immunotherapy has resulted in a paradigm shift the treatment of multiple solid tumors. Still, immunotherapy unselected pancreatic ductal adenocarcinoma (PDAC) patients been disappointing. This failure is likely multifactorial and associated with high immunosuppressive desmoplastic tumor microenvironment (TME). unique TME PDAC leads to various immune escape mechanisms employed by tumor. While this could be overcome therapy involving IL12 (or other cytokines) alone, they...