A5077087081- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Ferroptosis and cancer prognosis
- Inflammatory mediators and NSAID effects
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Cellular Mechanics and Interactions
- Cancer and Skin Lesions
- CRISPR and Genetic Engineering
- Cell Adhesion Molecules Research
- Healthcare Systems and Reforms
- Cancer Research and Treatment
- Digestive system and related health
Manipal Academy of Higher Education
2021-2024
St.John's Medical College Hospital
2017-2024
Sri Venkateshwaraa Medical College Hospital and Research Centre
2024
St. John's School
2022-2023
St. John's National Academy of Health Sciences
2016-2023
Annapoorana Medical College and Hospitals
2023
Thrombosis Research Institute
2021
Institute of Molecular Medicine
2020
HCG Cancer Hospital
2019
Institute of Medical Sciences
2014
The glucocorticoid receptor (GR) is frequently expressed in breast cancer (BC), and its prognostic implications are contingent on estrogen (ER) status. To address conflicting reports explore therapeutic potential, a GR signature (GRsig) independent of ER status was developed. We also investigated cell type-specific protein expression BC tumor epithelial cells infiltrating lymphocytes. GRsig derived from Dexamethasone treated lines through bioinformatic pipeline. Immunohistochemistry assessed...
<title>Abstract</title> Triple-negative breast cancer (TNBC) lacks targeted therapies, leading to poor prognosis. Younger TNBC patients exhibit distinct tumor microenvironments and aggressive disease. We explored the influence of menopausal status on immune landscapes, progression, therapy response using spatial profiling. Eleven treatment-naïve tumors were analyzed in epithelial non-epithelial areas, revealing clusters for premenopausal with upregulated antigen presentation cell activation...
Abstract Integrin α v β 6 is involved in the transition from ductal carcinoma situ ( DCIS ) to invasive IDC of breast. In addition, integrin ITGB 6) prognostic value breast cancers, particularly HER 2+ subtype. However, pathways mediating activity clinical progression cancers need further elucidation. We have examined human cancer specimens N = 460) for expression mRNA by qPCR . we a subset 147) immunohistochemistry IHC ). The levels members Rho–Rac pathway including downstream genes ACTR 2...
Androgen receptor (AR) is considered a marker of better prognosis in hormone positive breast cancers (BC), however, its role triple negative cancer (TNBC) controversial. This may be attributed to intrinsic molecular differences or scoring methods for AR positivity. We derived regulated gene score and examined utility BC subtypes. genes were by applying bioinformatic pipeline on publicly available microarray data sets AR+ cell lines was calculated as average expression six genes. Tumors...
Abstract Despite the established benefits of long‐term endocrine therapy, women with hormone receptor‐positive breast cancer remain at risk for late relapse. The basis this is multi‐factorial including genetic, epigenetic, and host factors. In study we have explored epigenetic regulation estrogen receptor (ER)‐dependent molecular cellular phenotype by hsa‐miR‐18a‐5p using well‐established human ER‐positive (ER+) cell lines. miR‐18a was overexpressed in MCF7 ZR‐75‐1 led to an increase...
Abstract Purpose Young premenopausal women develop breast cancer (BC) within 5–10 years of the last childbirth, known as post-partum cancers (PPBC), often present with aggressive disease. The exact mechanisms that lead to poor prognosis in these patients are largely unknown. Methods We have evaluated association clinical and reproductive factors BC a cohort ≤ 45 ( N = 155) long-term follow-up. Based on duration since childbirth (LCB), grouped into PPBC1 (LCB 5 years), PPBC2 between 6 10...
Purpose Apart from germ-line BRCA1-mutated breast cancers, a significant proportion of women with sporadic triple negative cancer (TNBC) sub-type are known to harbour varying levels BRCA1-dysfuction. There is currently no established diagnostic method identify these patients. Methods The analysis was performed on 183 primary tumor specimens our longitudinal case-series archived as formalin-fixed-paraffin-embedded (FFPE) blocks comprising 71 TNBCs and 112 Hormone receptor positive HER2...
Women with breast tumors higher expression of AR are in general known to have better survival outcomes while a high AR/ER ratio is associated poor hormone receptor positive cancers mostly post menopausal women. We evaluated the context circulating androgens specifically patients younger than 50 years most whom pre-menopausal and hence estrogenic hormonal milieu.Tumor samples from or at first diagnosis were chosen larger cohort 270 median follow-up 72 months. Expression levels ER proteins...
<title>Abstract</title> <bold>Background</bold> Triple-negative breast cancer (TNBC) is characterized by a lack of targeted therapies, leading to poor prognosis. Premenopausal TNBC often has different clinical outcomes compared postmenopausal patients, influenced their hormonal milieu and its impact on the tumor microenvironment (TME). This study used Digital Spatial Profiling (DSP) explore these differences comprehensively. <bold>Methods</bold> We analyzed 11 treatment-naive tumors...
Abstract Breast cancer (BC) among premenopausal women is an aggressive disease associated with poor outcome despite intensive treatment. Higher burden observed in southeast Asian countries attributed to younger population structure. We compared the reproductive and clinicopathological characteristics, distribution of subtypes survival between pre postmenopausal from a retrospective cohort BC patients median follow up over 6 years examine differences. In our 446 patients, 162/446 (36.3%) were...
Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present advanced disease, many such patients do well. We have attempted identification biologically indolent tumors within HR+HER2- based on gene expression using histological grade as guide to tumor aggression. 144 were divided into subclasses scores derived by transcript levels multiple genes representing survival, proliferation, and apoptotic...
Hyponatremia is one of the most common electrolyte abnormalities in hospitalized patients. The treatment hyponatremia controversial as rapid correction serum sodium can give rise to neurologic disorder and at same time if not corrected timely, it lead brain damage. aim this study was compare efficacy Tolvaptan with 3% hypertonic saline solution for management patients.In prospective observational study, data 60 patients having from February 2013 July were collected analyzed. Patients either...
Human epidermal growth factors play an important role in ovarian carcinogenesis and are evaluated for prognostic possible therapeutic roles high-grade serous malignancies. The present study was undertaken to evaluate the expression of human factor receptor 2 (HER2) (EGFR) advanced stage carcinoma their influence on prognosis. HER2 EGFR studied 59 cases III IV carcinomas by immunohistochemistry fluorescent situ hybridization. Of 48 interpretable tumors HER2, 6 (12.5%) were scored as positive,...
Colorectal cancer (CRC) is a complex disease as shown by consensus classification. The present study attempted to identify subtypes with known prognostic markers for better clinical management. A total of 72 CRC tumors were examined the expression mismatch repair (MMR) proteins, along caudal-type homeobox protein 2 (CDX2) and BRCA1, immunohistochemistry. Tumors assigned based on presence or loss MMR proteins proficient deficient. Correlations CDX2 BRCA1 clinico-pathological features....
Abstract The complexity of the ER-negative subtype breast cancer arises due to heterogeneous nature disease rendering them more aggressive and this poses a challenge effective treatment eventually prognosis patients. We have explored miRNA regulation altered molecular signatures effect on tumour progression in cancer. Using specimens, gene expression data from public datasets in-vitro in-vivo model systems we shown that low-levels miR-18a tumours drives enrichment hybrid...
Abstract Background: World over, less than a quarter of breast cancer diagnoses are in premenopausal women. However, India women constitute half all with most hospital case series. Most these present at advanced stages aggressive subtypes disease and hence the high mortality.The role utility detecting androgen receptor (AR) expression different sub-types cancer, especially ones without hormone is yet to be firmly established. Evidence from previous studies suggestive its beneficial positive...
Abstract Background : The glucocorticoid receptor (GR) is frequently expressed in breast cancer (BC), and its prognostic implications are contingent on estrogen (ER) status. To address conflicting reports explore therapeutic potential, a GR signature (GRsig) independent of ER status was developed. We also investigated cell type-specific protein expression BC tumor epithelial cells infiltrating lymphocytes. Methods GRsig derived from Dexamethasone-treated lines through bioinformatic pipeline....
Abstract Background Breast cancers (BC) in the young women tend to have poor outcomes and higher proportion of aggressive subtypes. Immunotherapy has shown promising results lately, especially for categories like triple negative breast (TNBC). Success immunotherapy is be dependent on tumor immune microenvironment (TIME) which plays important role disease progression response therapy. Though numerous studies demonstrated hot tumors are associated with better prognosis, mechanism...
Epigenetic alterations that lead to differential expression of microRNAs (miRNAs/miR) are known regulate tumour cell states, epithelial-mesenchymal transition (EMT) and the progression metastasis in breast cancer. This study explores key contribution miRNA-18a mediating a hybrid E/M state is pivotal malignant transformation aggressive ER-negative subtype The status associated effects miR-18a were evaluated patient-derived samples combination with gene data from public datasets, further...
Background: Thyroid nodules are common clinical findings that appear as distinct lesions within the thyroid gland, identifiable through radiological imaging. Sonographic evaluation, particularly using Imaging Reporting and Data System (TIRADS) elastography, has become essential in assessing managing these nodules. This study aims to evaluate diagnostic accuracy utility of TIRADS conjunction with Fine-Needle Aspiration Cytology (FNAC), for a comprehensive assessment lesions. Methodology: A...
The main aim of the study was to comparative single dose prophylactic antibiotic versus empirical postoperative antibiotics in prevention surgical site infection. a prospective observational conducted over period 8months. A total 100 number surgery cases were selected randomly, groups 50 each. group received preoperatively while control 3 5 days therapy. Data analysis and statistical done with help graph pad prism trial version software. Student t test carried out for paired find P value....
Abstract In high grade serous ovarian cancers (HG-SOC), BRCA1/2 mutations have been reported as the most predominant by various studies. However, non-mutational mechanisms of BRCA pathway inactivation in HG-SOC are unclear. We aimed to evaluate BRCA1 estimating its expression along with repressor primary and neoadjuvant chemotherapy (NACT) treated tumors known therapeutic response. The pattern protein was evaluated immunohistochemistry (IHC) 119 cases from a hospital cohort consisting (N=...
<title>Abstract</title> Background Though pregnancy and lactation are considered as protective factors against development of breast cancer (BC), small proportion young premenopausal women develop tumors within 5 to 10 years last childbirth presenting with aggressive disease. The exact mechanisms that lead poor prognosis in these postpartum cancers (PPBC) is largely unknown. Methods We have evaluated the association clinical reproductive BC a cohort ≤ 45 (N = 155) long term follow up. Based...