A5038876364- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Pomegranate: compositions and health benefits
- Birth, Development, and Health
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Mental Health Treatment and Access
- Schizophrenia research and treatment
- Reproductive System and Pregnancy
- Neuroblastoma Research and Treatments
- Psychotherapy Techniques and Applications
- Immune cells in cancer
- Family Caregiving in Mental Illness
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Phytochemical compounds biological activities
- Psychosomatic Disorders and Their Treatments
- Pharmacy and Medical Practices
- Salmonella and Campylobacter epidemiology
- Personality Disorders and Psychopathology
- Antioxidant Activity and Oxidative Stress
- Bioactive Compounds in Plants
- Aquaculture disease management and microbiota
Rajiv Gandhi Centre for Biotechnology
2020-2024
Introduction: The combination of lithium and valproate is the most recommended treatment for relapse prevention in Bipolar Affective Disorder (BPAD) after failure monotherapy. If it proven that functioning, quality life cognitive functioning bipolar patients on a sodium are better than those monotherapy, this could further encourage use therapy. Aim: To compare euthymic therapy with Materials Methods: present hospital-based crosssectional study was conducted Outpatient Department, Institute...
The brain, protected by the cranium externally and blood-brain barrier (BBB) internally, poses challenges in chemotherapy of aggressive brain tumors. Maximal tumor resection followed radiation is standard treatment protocol; however, a substantial number patients suffer from recurrence. Systemic circulation drugs causes myelodysplasia other side effects. To address these caveats, we report facile synthesis polyester-based supramolecular hydrogel as biocompatible implant for situ delivery...
The triple negative breast cancer (TNBC) subtype is one of the most aggressive forms that has poor clinical outcome and an unmet challenge. Accumulating evidence suggests intratumoral heterogeneity or presence phenotypically distinct cell populations within a tumor play crucial role in chemoresistance, progression metastasis. An increased understanding molecular regulators to development effective therapeutic strategies TNBC. To this end, we used unbiased approach identify mediator by...
Notch signaling and its downstream gene target HES1 play a critical role in regulating maintaining cancer stem cells (CSCs), similar to as they do during embryonic development. Here, we report unique subclass of Notch-independent Hes-1 (NIHes-1)-expressing CSCs neuroblastoma. These maintain sustained expression by activation promoter region upstream classical CBF-1 binding sites, thereby completely bypassing receptor-mediated activation. have self-renewal ability potential generate tumors....
Luminal breast cancer subtypes respond poorly to endocrine and trastuzumab treatments due cellular heterogeneity arising from the phenotype transitions, accounted for mainly by loss of receptor expression. The origins basal-like human epidermal growth factor 2 (HER2)-overexpressing have been attributed genetic protein modifications in stem-like cells luminal progenitor cell populations, respectively. post-transcriptional regulation expression is known be influenced microRNAs (miRNAs) that...
BRCA1 mutation is reported in about 70% of all triple negative breast cancers (TNBC), while defect due to promoter hypermethylation seen 30%-60% sporadic cancers. Although PARP inhibitors and platinum-based chemotherapy are used treat these cancers, more efficient therapeutic approaches required overcome the resistance treatment. Our previous findings have elevated βhCG expression but not αhCG deficient As causes immune suppression pregnancy, this study explored immunomodulatory effect...
27-hydroxycholesterol (27-HC) is an oxysterol that acts as endogenous selective estrogen receptor modulator (SERM), and its adverse effects on breast cancer via the (ER) have provided new insights into pathology of cholesterol-linked cancer. Our earlier in vitro experiments showed methanolic extract pomegranate could exhibit SERM properties compete with 27-HC. The major constituents are ellagitannins ellagic acid, which converted urolithins by colonic microbiota. In recent years, urolithins,...
Abstract The complexity of the ER-negative subtype breast cancer arises due to heterogeneous nature disease rendering them more aggressive and this poses a challenge effective treatment eventually prognosis patients. We have explored miRNA regulation altered molecular signatures effect on tumour progression in cancer. Using specimens, gene expression data from public datasets in-vitro in-vivo model systems we shown that low-levels miR-18a tumours drives enrichment hybrid...
Chandipura virus (CHPV) is an emerging human pathogen of great clinical significance. In this study, we have investigated the susceptibility pattern both normal and cancer cell lines origin to wild-type (wt) CHPV in order explore possibility developing as oncolytic vector (OV). Marked cytopathic effect along with enhanced output was observed (HeLa, A549, U-138, PC-3, HepG2) comparison adult dermal fibroblast (HADF) cells. At MOI 0.1, were differentially susceptible CHPV, cells like HeLa...
Epigenetic alterations that lead to differential expression of microRNAs (miRNAs/miR) are known regulate tumour cell states, epithelial-mesenchymal transition (EMT) and the progression metastasis in breast cancer. This study explores key contribution miRNA-18a mediating a hybrid E/M state is pivotal malignant transformation aggressive ER-negative subtype The status associated effects miR-18a were evaluated patient-derived samples combination with gene data from public datasets, further...
Abstract Introduction Non-alcoholic steatohepatitis (NASH) is characterized by excessive accumulation of fat, accompanied inflammation and liver injury. NASH can lead to chronic conditions like fibrosis cirrhosis, has an elevated risk progressing hepatocellular carcinoma (HCC). Currently there are no FDA-approved drugs for the treatment NASH. Objectives Our discovery Uttroside B (Utt-B), a phytosaponin isolated from Solanum nigrum Linn., which exhibits remarkable anti-HCC potential, gained...
The triple-negative breast cancer (TNBC) subtype is one of the most aggressive forms that has poor clinical outcome and still remains as an unmet challenge. Accumulating evidence suggests intratumoral heterogeneity or presence phenotypically heterogeneous cell populations within a tumor plays crucial role in chemoresistance, progression metastasis. Increased understanding molecular regulators will enable development effective therapeutic strategies TNBC. We have identified mediator involved...
Abstract BRCA1 mutation predisposes to tumors mainly the breast and ovaries, though exact reason for said tissue specificity still remains a mystery. We have shown that when cancer cells become defective in BRCA1, hCG is overexpressed. Also, we demonstrated β-hCG can promote tumor progression by inducing TGFβRII, specifically selectively vitro (Sengodan et al., 2017). induces expression of hemoglobin genes protects during oxidative stress, resulting drug resistance Since has...
ABSTRACT Women with a family history of mutations in the Breast cancer susceptibility gene, BRCA1 will have an increased risk developing breast neoplasms. However, majority cancers are sporadic where very rare. Instead, 5-65% cases manifest promoter hypermethylation and 30-40% such develop into Triple Negative Cancers. Even then, molecular mechanism mediated tumorigenesis has remained enigma till date. Here, we present novel pathway for that engenders from by generating site-specific...
Aims: Maternal hypercholesterolemia (MHC) is a pathological condition that may cause atherosclerosis in the adulthood of offspring. The study aims to identify role in-utero programming by placenta atherogenesis and associated liver pathology offspring.Main methods: Female New Zealand white rabbits with normal lipid profiles were fed 0.3% HFD after mating. Lipid levels monitored, pregnant sacrificed at end trimester 1, 2, 3. Placental histology expression metabolism genes studied. levels,...
Schizophrenia is a severe mental disorder affecting 3-5 / 1000 of the general population at any given time in society. In India, caregivers family play vital role providing care by attending to physical and emotional needs their ill relatives. It tends affect young people during most productive years and, if left untreated, illness can continue till end. The management schizophrenia be challenging. Hence, it inevitable that need have knowledge about illness, treatment available support for...