A5081155932- Birth, Development, and Health
- Oral Health Pathology and Treatment
- Curcumin's Biomedical Applications
- Signaling Pathways in Disease
- Pregnancy and preeclampsia studies
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Apelin-related biomedical research
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related molecular mechanisms research
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Genetic Associations and Epidemiology
- Gestational Diabetes Research and Management
- Tissue Engineering and Regenerative Medicine
- Cancer, Lipids, and Metabolism
- Cerebrovascular and genetic disorders
- Traditional and Medicinal Uses of Annonaceae
- Cardiac Fibrosis and Remodeling
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
Gujarat Biotechnology University
2023-2024
Rajiv Gandhi Centre for Biotechnology
2014-2023
Gujarat National Law University
2023
Gujarat Technological University
2023
Regional Cancer Center, Thiruvananthapuram
2005
Abstract Oral leukoplakia is a potentially malignant lesion of the oral cavity, for which no effective treatment available. We investigated effectiveness curcumin, potent inhibitor NF-κB/COX-2, molecules perturbed in carcinogenesis, to treat leukoplakia. Subjects with (n = 223) were randomized (1:1 ratio) receive orally, either 3.6 g/day curcumin 111) or placebo 112), 6 months. The primary endpoint was clinical response obtained by bi-dimensional measurement size at recruitment and...
Cyclophilin A, an immunophilin is secreted from human monocytes activated by high glucose. Given its role as inflammatory mediator of vascular tissue damage associated with inflammation and oxidative stress, we examined plasma levels cyclophilin A in normal healthy volunteers patients type 2 diabetes (DM), or without coronary artery disease (CAD).Study subjects comprised 212 DM CAD,101 diabetes, 122 CAD 121 volunteers. Diabetes was assessed HbA1c while established a positive treadmill test...
Hyperglycemia is widely recognized to be a potent stimulator of monocyte activity, which crucial event in the pathogenesis atherosclerosis. We analyzed proteome for potential markers that would enhance ability screen early inflammatory status Type 2 diabetes mellitus (T2DM), using proteomic technologies. Monocytic cells (THP-1) were primed with high glucose (HG), their protein profiles 2DE and downregulated differentially expressed spots identified MALDI TOF/MS. selected five proteins...
Vascular disease in diabetes is initiated by monocyte adhesion to vascular endothelium, transmigration and formation of foam cells. Increasing clinical evidence supports a role for the secretory protein, cyclophilin A diabetic disease. The means which contributes lesion development however largely unknown. In this study we investigated using THP1 cells human monocytes whether under hyperglycemic conditions, functions inflammatory cascade as chemoattractant increases lipid uptake invitro. We...
Growing evidence implicates cyclophilin A secreted by vascular wall cells and monocytes as a key mediator in atherosclerosis. Cyclophilin addition to its proliferative effects, during hyperglycemic conditions, increases lipid uptake macrophages increasing scavenger receptors on the cell’s surface. It also promotes macrophage migration across endothelial conversion of into foam cells. Given known effects metformin reducing complications diabetes, we investigated effect action macrophages....
Impairment of efferocytosis in apoptotic macrophages is a known determinant the severity atherosclerosis and vulnerability plaques to rupture. The precise mechanisms involved impaired are unclear. Given well-recognized role inflammatory cytokine cyclophilin A (Cyp A) modulating several atherogenic high-glucose primed monocytes, we investigated Cyp macrophage efferocytosis. efficiency RAW 264.7 grown vitro with was assessed using flow cytometry confocal assays. Cholesterol content cells...
<h3>Objective</h3> Human papillomavirus oncoproteins E6 and E7 down modulate Toll-like receptor (TLR) 9 expression in infected keratinocytes. We explored the status of function TLR7, TLR8, TLR9 primary human Langerhans cells (LCs) isolated from cervical tumors. <h3>Methodology</h3> Single-cell suspensions were made fresh tissues squamous cell carcinoma (International Federation Gynecology Obstetrics stage IB2); myeloid dendritic purified using CD1c magnetic activated separation kits. further...
Heart failure (HF) is emerging as a major health problem in India. The profile of HF India divergent from elsewhere the world. While cardiologists must equip themselves with requisite clinical management tools, scientists and policymakers would need epidemiological data on information resources required to meet challenges ahead. aim this study was identify lacunae suggest recommendations improve research.We surveyed multidisciplinary group experts using two stage process. An email-based...
Macrophage apoptosis is a key contributor to the progression of atherosclerosis. Cyclophilin A, monocyte secretory protein associated with initiation atherosclerosis has an inherent nuclease activity. This study reports mechanism by which cyclophilin A causes macrophages and accelerates Aortic lesion formation were studied in New Zealand White rabbits (NZW) fed high-fat diet (HFD) for 12 weeks. Using monocytes HFD-fed we demonstrate that induces mitochondrial membrane potential loss pore...
Abstract Cardiac tissue engineering using cells, scaffolds or signaling molecules is a promising approach for replacement repair of damaged myocardium. This study addressed the contemporary need conductive biomimetic nanocomposite scaffold cardiac by examining use gold nanoparticle‐incorporated porcine cholecystic extracellular matrix same. The had an electrical conductivity (0.74 ± 0.03 S/m) within range native It was suitable substrate growth and differentiation cardiomyoblast (H9c2) as...
Fibrosis that occurs after nonfatal myocardial infarction (MI) is an irreversible reparative cardiac tissue remodeling process characterized by progressive deposition of highly cross-linked type I collagen. No currently available therapeutic strategy prevents or reverses MI-associated fibrotic scarring myocardium. In this study, we used epicardial graft prepared porcine cholecystic extracellular matrix to treat experimental MI in rats. Graft-assisted healing was reduced fibrosis, with scanty...