A5021651694- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Genetics, Bioinformatics, and Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Phosphodiesterase function and regulation
- Renal and related cancers
- Microtubule and mitosis dynamics
- Angiogenesis and VEGF in Cancer
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Asthma and respiratory diseases
- Mast cells and histamine
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
Ollscoil na Gaillimhe – University of Galway
2021-2022
Rajiv Gandhi Centre for Biotechnology
2010-2020
Pfizer (United Kingdom)
2011
Breast cancer is an aggressive disease of multiple subtypes with varying phenotypic, hormonal, and clinicopathological features, offering enhanced resistance to conventional therapeutic regimens. There unmet need for reliable molecular biomarkers capable detecting the malignant transformation from early stages enhance diagnosis treatment outcomes. A subset small non-coding nucleic acid molecules, micro ribonucleic acids (microRNAs/miRNAs), have emerged as promising due their role in gene...
BackgroundHuman epidermal growth factor receptor-2 (HER2) is overexpressed in 20–25% of breast cancers. Complete eradication disease following neoadjuvant therapies and chemotherapy has been referred to as pathological complete response (pCR).AimsTo determine clinicopathological predictors pCR evaluate a surrogate enhanced survival.MethodsConsecutive female patients with HER2 positive (HER+) cancer managed surgically single institution between 2005 2015 were included. Descriptive statistics...
Luminal breast cancer subtypes respond poorly to endocrine and trastuzumab treatments due cellular heterogeneity arising from the phenotype transitions, accounted for mainly by loss of receptor expression. The origins basal-like human epidermal growth factor 2 (HER2)-overexpressing have been attributed genetic protein modifications in stem-like cells luminal progenitor cell populations, respectively. post-transcriptional regulation expression is known be influenced microRNAs (miRNAs) that...
Type 7 phosphodiesterases (PDE7) are responsible for the decrease of intracellular cyclic AMP (cAMP) in many cells involved allergic asthma by suppressing their potential to respond activating stimuli. The elevation cAMP has been associated with immunosuppressive and anti-inflammatory activities represents a treatment asthma. Our aim was evaluate impact deletion murine phosphodiesterase (PDE)7B gene then efficacy newly described selective PDE7A -B inhibitor on an ovalbumin (OVA)-induced...
This study is an integrated analysis of the transcriptome profile microRNA (miRNA) and its experimentally validated mRNA targets differentially expressed in tumorigenic stem-like fraction oral squamous cell carcinoma (OSCC). We had previously reported coexistence multiple drug-resistant fractions, termed side population (SP1, SP2, MP2), a nontumorigenic fraction, main (MP1), cancer. These fractions displayed self-renewal, regenerative potential known stemness-related surface markers despite...