Purpose: To investigate the proportion, risk factors, and of recurrence nephrolithiasis to determine type, size, location, treatment patterns kidney stones. Materials methods: This single-centered prospective study comprised 300 patients with (age, 18–90 years) who were admitted Caritas Hospital in India between October 2022 March 2023. A control group was included significance dietary lifestyle factors nephrolithiasis. Patient demographics, clinical data, therapeutic data collected from...

A series of thienylchalcones with fluoro and trifluoromethyl derivatives were synthesized evaluated for their capability to inhibit human monoamine oxidase B. The chemical structures the compounds have been ascertained by means 1HNMR, 13CNMR, mass spectroscopic data elemental analysis. results documented that these revealed moderate good inhibitory activities towards MAO-B than MAO-A. most active compound, (2E)-1-(thiophen-2-yl)-3-[4-(trifluoromethyl) phenyl] prop-2-en-1-one exhibited Ki...

Monoamine oxidase-A and B have been studied over a long period as one of the promising drug targets for treatment depression neurodegenerative disorders. Commonly, MAO-A is associated with because its relation control serotonin levels. On other hand, MAO-B has Alzheimer's Parkinson's diseases this enzyme modulates dopamine levels in CNS. The major objective research field devoted to identify isolate selective ligands MAO-A/MAO-B so that undesirable side effects due non-selective inhibition...

Background Hand-foot syndrome is a common adverse effect of 5-fluorouracil infusion or oral capecitabine. Several types research have shown that clinical presentations hand-foot vary by ethnicity, so we tried to look at the incidence and severity in individuals receiving infusional capecitabine tertiary care hospital central Kerala, India. Aim To determine cancer patients chemotherapy regimen. Methodology A prospective cohort study was conducted oncology department Our subjects were those...

Context: Xanthine oxidase is a key enzyme in purine metabolism with an important role various pathological conditions including gout and oxidative stress. Many of the synthetic candidates showed remarkable activity greater amount side effects. Thus search promising structural core like flavonoids emerged attention for inhibition xanthine oxidase. Objective: The objective this review to provide detailed knowledge flavonoidal class compounds natural derivatives lays emphasis on structure...

Hyponatremia is one of the most common electrolyte abnormalities in hospitalized patients. The treatment hyponatremia controversial as rapid correction serum sodium can give rise to neurologic disorder and at same time if not corrected timely, it lead brain damage. aim this study was compare efficacy Tolvaptan with 3% hypertonic saline solution for management patients.In prospective observational study, data 60 patients having from February 2013 July were collected analyzed. Patients either...

Coronavirus disease 2019 (COVID-19) was declared an epidemic and a global health emergency by the World Health Organization (WHO), prompting various countries to implement early stringent social distancing protocols through lockdown, flatten curve. The objective of our present study assess impacts effectiveness lockdown protocol in Karnataka Punjab, compared with implementation this method Australia United Kingdom (UK). This involved collection data from different authorized databases, two...

Background: The role of ascorbic acid in cancer therapy is mainly due to its structural similarity with glucose. When supplemented intravenously high dose, can get into the cells and induce apoptosis by causing mitochondrial damage. Aim: aim was study efficacy high-dose intravenous (IV) as monotherapy patients following ketogenic diet improving quality life. Results: C-reactive protein (CRP) erythrocyte sedimentation rates (ESRs) were considered parameters determine treatment, substantial...

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare potentially life-threatening hypersensitivity cutaneous presentation internal organ involvement. We herein present case of phenytoin induced DRESS in 56- year-old male who presented high-grade fever chills, cough expectoration generalized maculopapular rash. Laboratory findings revealed eosinophilia, leukocytosis, thrombocytopenia, transaminitis elevated inflammatory markers. Further clinical, radiological...

Hydrazone core is a versatile structural linker for the development of various classes antiepileptic agents. The aim this study was to investigate anticonvulsant activity thiophene based hydrazones according drug program protocol.

Objective: To compare the impact of lockdown in Maharashtra, Kerala and United States. Methodology: We conducted a prospective observational study order to assess between Kerala, Maharashtra States (US). The involved collection data from two phases. first phase is time index case reported each country till 14th day after declaration that country. second collected 15th 28th lockdown. Data storage analysis were performed using Microsoft excel SPSS version 24. Result: As per 21st April, 426...

Abstract: Pancreatico-pleural Fistula is rare complication of chronic pancreatitis and it occurs in considerably less number patients. We present a case left sided pleural effusion that was attributable to pancreatico-pleural fistula. A 30-year old alcoholic patient who had worsening dyspnea, hemoptysis intractable cough. Diagnosis difficult due the prevalance respiratory symptoms than pancreatitis. concluded by detection high level amylase lipase fluid ERCP. It been managed placing stent on...

Background The novel coronavirus disease (COVID-19) has been recognized as a global threat, and several studies are being conducted using various mathematical models to predict the probable evolution of this epidemic, which subject potential bias. In study, we aimed assess compare impact lockdown among Punjab, Delhi, Gujarat states India Auto Regressive Integrated Moving Average (ARIMA) model by comparing forecasted COVID-19 data with real-time data. Methods We analyzed Indian from index...

Abstract Background The novel corona virus disease (COVID-19) was declared as pandemic by World health organisation (WHO) on the 11 th of March 2020. India one among countries in world to declare longest lock down across nation order resist spread COVID-19. It a challenge assess medical care chronic patients during these days. Methodology We adopted cross sectional survey design conditions and perceptions with cardiovascular metabolic co-morbidities those autoimmune rheumatic diseases...

Abstract: Telmisartan is a widely used antihypertensive drug that effectively lowers blood pressure. In this report, we present the case of patient who developed acute kidney injury after taking an ARB inhibitor, Telmisartan. A 40-year old, male known Congestive heart failure and dilated cardiomyopathy got admitted to emergency department with breathlessness cough. He was diabetic for past four years on Insulin. also hypertensive 11 All his parameters except renal function tests (blood urea,...

Introduction: Cross sectional study is a type of observational that analyzes data from apopulation, or representative subset, at specific point in time-that is, cross data. The causality appraisal assessment the probability detected adverse event produced by medication. most commonly used scales are Naranjo Probability Scale and World Health Organization-Uppsala Monitoring Centre (WHO-UMC) scales. to analyze drug reaction reported hospital for past three years. Aim: A ADR during Methodology:...

Up to 14 days before your period begins, you might see bulging, Migraines, temperament swings, or other physical and enthusiastic changes. These Month month side effects are known as premenstrual disorder, PMS. Around 85% of ladies experience some level A couple have more serious. Manifestations that disturb work individual connections, Dysphoric problem (PMDD). The etiology these disorders remains uncertain, Research suggests altered regulation neurohormones neurotransmitters is involved....

Case Summary: An 84-year-old man was admitted to the hospital due seizure episodes. One week before patient same with complaints of COPD exacerbation and discharged a prescription levofloxacin, theophylline ceftriaxone, pantaprazole, montelukast, methylprednisolone, budesonide nebulization, ipratropium bromide syrup codylex. After receiving one dose oral experienced seizure. The hyperglycaemic at time admission had no history disorder. Discussion: Here cause could be drug-drug interaction...

Objective: To report a case of liposomal doxorubicin induced anaphylaxis. Case Summary:  A 43 year old female patient with metastatic carcinoma endometrium was admitted to the hospital chief complaints abdominal pain, distention and vomiting. Due disease progression she planned for chemotherapy doxorubicin. But developed anaphylactic reaction in 1st dose drug stopped. Therapy discontinued got recovered. Discussion: Liposomal is formulation packed liposome polyethylene glycol covering....

Abstract Chromoblastomycosis (CBM) is a chronic progressive cutaneous fungal infection caused by several naturally pigmented fungi which are commonly seen in tropical and subtropical climates. The secondary to trauma or autoinoculation. A majority of the cases from India reported sub-Himalayan belt South India. Fungal diseases other than mycetoma considered neglected World Health Organization. global burden CBM could be even greater can lead potential incapacity for labor. Here, we present...