A5038680349- Ocular Infections and Treatments
- MicroRNA in disease regulation
- Seed Germination and Physiology
- RNA modifications and cancer
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Corneal Surgery and Treatments
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Plant Genetic and Mutation Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Plant responses to water stress
- Plant tissue culture and regeneration
- Plant biochemistry and biosynthesis
- Sepsis Diagnosis and Treatment
- Gene expression and cancer classification
- Circular RNAs in diseases
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Tuberculosis Research and Epidemiology
- Religion, Spirituality, and Psychology
- Plant Micronutrient Interactions and Effects
- Phytochemicals and Medicinal Plants
- Bioinformatics and Genomic Networks
University of Agricultural Sciences, Bangalore
2001-2010
Yale University
2002-2008
Whitney Museum of American Art
2002
National Centre for Biological Sciences
2001
University of Agricultural Sciences, Dharwad
1999
Goa Medical College
1978
An analysis of protein-protein interactions in Arabidopsis identifies the plant interactome.
Ocimum sanctum L. (O. tenuiflorum) family-Lamiaceae is an important component of Indian tradition medicine as well culture around the world, and hence known "Holy basil" in India. This plant mentioned ancient texts Ayurveda "elixir life" (life saving) herb worshipped for over 3000 years due to its healing properties. Although used various ailments, validation molecules differential activities yet be fully analyzed, about 80 % patents on this are extracts or parts, mainly focussed essential...
Aspergillus flavus, one of the causative agents human fungal keratitis, can be phagocytosed by corneal epithelial (HCE) cells and conidia containing phagosomes mature into phagolysosomes. But immunological responses interacting with A. flavus are not clear. In this study, we report expression immune response related genes HCE exposed to spores using targeted transcriptomics.Human cell line primary cultures were grown in a six-well plate used for coculture experiments. Internalization was...
<title>Abstract</title> Triple-negative breast cancer (TNBC) lacks targeted therapies, leading to poor prognosis. Younger TNBC patients exhibit distinct tumor microenvironments and aggressive disease. We explored the influence of menopausal status on immune landscapes, progression, therapy response using spatial profiling. Eleven treatment-naïve tumors were analyzed in epithelial non-epithelial areas, revealing clusters for premenopausal with upregulated antigen presentation cell activation...
Little is known about the protein complexes required for microRNA formation and function. Here we used native gel electrophoresis to identify miRNA ribonucleoprotein (miRNPs) in Caenorhabditis elegans . Our data reveal multiple distinct miRNPs that assemble on let-7 vitro. The of these affected but not abolished by alg-1 or alg-2 null mutations. largest complex (M*) with an estimated molecular mass >669 kDa cofractionates RISC factors ALG-1, VIG-1, TSN-1. M* two complexes, M3 M4, similar...
<title>Abstract</title> <bold>Background</bold> Triple-negative breast cancer (TNBC) is characterized by a lack of targeted therapies, leading to poor prognosis. Premenopausal TNBC often has different clinical outcomes compared postmenopausal patients, influenced their hormonal milieu and its impact on the tumor microenvironment (TME). This study used Digital Spatial Profiling (DSP) explore these differences comprehensively. <bold>Methods</bold> We analyzed 11 treatment-naive tumors...
Occurrence and features of 130 suicide cases were studied in a culturally distinct community, Goa (India), which was isolated from mainland for over 450 years records obtained the police information collected close relatives deceased analyzed retrospectively. It noted that cultural religious factors continue to play an important role suicidal behaviour India. The rate higher males as compared with females greater joint family than nuclear family. Similarly, married persons both sexes had...
Background Monocyte miRNAs govern both protective and pathological responses during tuberculosis (TB) through their differential expression emerged as potent targets for biomarker discovery host-directed therapeutics. Thus, this study examined the miRNA profile of sorted monocytes across TB disease spectrum [drug-resistant (DR-TB), drug-sensitive (DS-TB), latent TB] in healthy individuals (HC) to understand underlying pathophysiology regulatory mechanism. Methods We total including three...
<title>Abstract</title> Hepatocellular carcinoma (HCC) is a of epithelial origin. While there are several factors, specific genetic and epigenetic landscapes define the initiation progression HCC. Genetic mutations, particularly missense often act as predictors onset cancers, including Specifically, mutations associated with telomerase, TP53, beta-catenin (CTNNB1) among three most commonly mutated genes in These subtypes HCC, exhibiting expression patterns terms miRNA interactome. In our...
Septic shock is associated with high mortality and there significant heterogeneity in the host response. The aim of this study was to understand genome-wide expression transcriptomic signatures children septic correlate them outcomes.
Prostate cancer (PCa) is one of the burgeoning cancers worldwide. Of late, number cases in Indian subcontinent has been doubling and incidence as per population-based registries (PBCR) increased at an alarming rate. In assessing trends PCa, there needs a statistical framework on incidence, comparing PBCRs vis-a-vis with hospital-based not only to that cohorts from India but also West other consortia. Our erstwhile pilot study inferring whole-exome sequencing variants yielded distinct...
ABSTRACT miRNAs are small non-coding RNAs that regulate most cellular processes. Tumorigenesis disrupts the normal balance in cell, which leads to changes cell cycle, signalling, activation of growth factors, miRNA deregulation, etc. Thus, variations expression between and tumor stages can be used predict, diagnose, detect identify different cancer stages, thereby suggesting potential use as biomarkers or therapeutic targets for cancer. In this study we aim differentially expressed could...