A5064640929- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related gene regulation
- RNA modifications and cancer
- Effects and risks of endocrine disrupting chemicals
- Cervical Cancer and HPV Research
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Metabolism and Genetic Disorders
- Computational Drug Discovery Methods
- Heavy Metal Exposure and Toxicity
- Ferroptosis and cancer prognosis
- FOXO transcription factor regulation
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Dental Radiography and Imaging
- Trace Elements in Health
- Dental materials and restorations
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
Manipal Academy of Higher Education
2016-2025
Shamnur Shivashankarappa Institute of Medical Sciences & Research Centre
2022
Kasturba Medical College, Manipal
2021
Manipal College of Medical Sciences
2021
Manipal-Tata Medical College, Jamshedpur
2021
Creative Commons
2017
DNA methylation and its perturbations are an established attribute to a wide spectrum of phenotypic variations disease conditions. Indian traditional system practices personalized medicine through indigenous concept distinctly descriptive physiological, psychological anatomical features known as prakriti. Here we attempted establish differences in these three prakriti phenotypes. Following structured objective measurement 3416 subjects, whole blood 147 healthy male individuals belonging...
Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia cancer biomarkers. In this study, we tested tissues at various stages of tumor progression for 5-methylcytosine 5-hydroxymethylcytosine levels also promoter profile a panel genes its diagnostic potential. total, 5-methylcytosine, 5-hydroxymethylcytosine, 33 were evaluated by reversed-phase high-performance liquid chromatography, enzyme-linked immunosorbent assay...
Young women (20-35 years) are at high risk of HPV infection, although the majority infections asymptomatic and cleared spontaneously by host immune system. These also group who sexually active in population pregnant women. During pregnancy, changes hormonal milieu response may favor persistence infection aid transgenerational transmission thereby furthering cancer risk. In present study, we determined prevalence vaginal early pregnancy attempted to relate with outcome.Vaginal cytology...
Abstract Background Cervical cancer continues to be a leading among women in India. Despite availability of various screening techniques, majority Indian remain unscreened for cervix. The increasing incidence could attributed the lack awareness regarding cervical and paucity organized facilities country. This study assessed knowledge, attitude practices (KAP) towards tribal coastal Karnataka, southern Methods A community-based cross-sectional was conducted 1140 aged 20–65 years from three...
Mitochondrial disorders are clinically complex and have highly variable phenotypes among all inherited disorders. Mutations in mitochon drial DNA (mtDNA) nuclear genome or both been reported mitochondrial diseases suggesting common pathophysiological pathways. Considering the clinical heterogeneity of encephalopathy, lactic acidosis stroke-like episodes (MELAS) phenotype including focal neurological deficits, it is important to look beyond gene mutation.The clinical, histopathological,...
Abstract Cervical cancer (CC) is a leading cause of cancer-related death among women in developing countries. However, the underlying mechanisms and molecular targets for therapy remain to be fully understood. We investigated epigenetic regulation, biological functions, clinical utility zinc-finger protein 471 (ZNF471) CC. Analysis cervical tissues five independent public datasets CC showed significant hypermethylation ZNF471 gene promoter. In cell lines, promoter DNA methylation was...
MicroRNAs (miRNAs) play a significant role in nuclear and mitochondrial anterograde retrograde signaling. Most of the miRNAs found inside mitochondria are encoded genome, with few genome-encoded non-coding RNAs having been reported. In this study, we have identified 13 microRNAs (mitomiRs), which were differentially expressed breast cancer cell lines (MCF-7, MDA-MB-468 MDA-MB-231), non-malignant epithelial line (MCF-10A), normal tissue specimens. We that DNA (mtDNA) depletion inhibition...
Cervical cancer (CC) is a key contributor to cancer-related mortality in several countries. The identification of molecular markers and the underlying mechanism may help improve CC management. We studied regulation biological function chromosome 14 microRNA cluster (C14MC; miR-379/miR-656) CC. Most C14MC members exhibited considerably lower expression tissues cell lines Cancer Genome Atlas (TCGA) cervical squamous carcinoma endocervical adenocarcinoma patient cohorts. Bisulfite Sanger...
Double C-2 Like Domain Beta (DOC2B) located at 17q13.3 prevents metastasis by senescence induction and epithelial to mesenchymal transition inhibition in cervical cancer (CC). The extracellular vesicle (EV) mediated trafficking of DOC2B its impact on tumor suppressive activity are not investigated CC. Using a retroviral method, we first ectopically expressed SiHa, which do normally express DOC2B. DOC2B-SiHa vector-SiHa EVs were co-incubated separately with recipient cell subjected various...