A5079950219- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Mass Spectrometry Techniques and Applications
- Cancer, Lipids, and Metabolism
- Parasites and Host Interactions
- Cancer Cells and Metastasis
- Integrated Circuits and Semiconductor Failure Analysis
- FOXO transcription factor regulation
- Glutathione Transferases and Polymorphisms
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Circular RNAs in diseases
The London College
2023
Imperial College London
2022-2023
Hammersmith Hospital
2022
Freemasons Foundation Centre for Men's Health
2016-2021
The University of Adelaide
2016-2021
Manipal Academy of Higher Education
2015-2021
Serum levels of miR-194 have been reported to predict prostate cancer recurrence after surgery, but its functional contributions this disease not studied. Herein, it is demonstrated that a driver metastasis. Prostate tissue were associated with aggressiveness and poor outcome. Ectopic delivery stimulated migration, invasion, epithelial-mesenchymal transition in human cell lines, stable overexpression enhanced metastasis intravenous intraprostatic tumor xenografts. Conversely, inhibition...
Abstract Alteration to the expression and activity of androgen receptor (AR) coregulators in prostate cancer is an important mechanism driving disease progression therapy resistance. Using a novel proteomic technique, we identified new AR coregulator, transcription factor Grainyhead-like 2 (GRHL2), demonstrated its essential role oncogenic signaling axis. GRHL2 colocalized with tumors was frequently amplified upregulated cancer. Importantly, maintained multiple model systems, required for...
Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can lead to emergence neuroendocrine cancer (NEPC), a phenomenon associated with enhanced cell plasticity. Here, we show that microRNA-194 (miR-194) is regulator epithelial-neuroendocrine transdifferentiation. In clinical samples, miR-194 expression and activity were elevated NEPC inversely correlated AR signaling. facilitated features cells, process mediated by its ability directly target suite genes...
Abstract Cervical cancer (CC) is a leading cause of cancer-related death among women in developing countries. However, the underlying mechanisms and molecular targets for therapy remain to be fully understood. We investigated epigenetic regulation, biological functions, clinical utility zinc-finger protein 471 (ZNF471) CC. Analysis cervical tissues five independent public datasets CC showed significant hypermethylation ZNF471 gene promoter. In cell lines, promoter DNA methylation was...
Prostate cancer (PCa) is a highly prevalent disease, causing the second largest amount of male deaths worldwide. Currently, prostate specific antigen (PSA) blood test remains standard serum prognostic and diagnostic monitoring biomarker but it lacks specificity sensitivity. PSA testing can lead to invasive biopsies which result in under detection clinically significant disease potential overtreatment indolent disease. There are promising circulating biomarkers could facilitate less more...
Prostate cancer (PCa) is the second most common cause of male cancer-related death worldwide. The gold standard treatment for advanced PCa androgen deprivation therapy (ADT). However, eventual failure ADT and leads to lethal metastatic castration-resistant PCa. As such, detection relevant biomarkers in blood drug resistance patients could lead personalized options. mRNA often limited by low specificity qPCR assays which are restricted specialized laboratories. Here, we present a novel...
ABSTRACT MicroRNA-194 (miR-194) promotes prostate cancer metastasis, but the precise molecular mechanisms by which it achieves this are unknown. Here, integrating Argonaute high-throughput sequencing of RNA isolated crosslinking immunoprecipitation (Ago-HITS-CLIP) with and exon-intron split analysis, we defined a 163-gene miR-194 “targetome” in cancer. These target genes were predominantly down-regulated through canonical 3’UTR recognition sites enriched within pathways involved cytoskeletal...
<div>Abstract<p>Serum levels of miR-194 have been reported to predict prostate cancer recurrence after surgery, but its functional contributions this disease not studied. Herein, it is demonstrated that a driver metastasis. Prostate tissue were associated with aggressiveness and poor outcome. Ectopic delivery stimulated migration, invasion, epithelial–mesenchymal transition in human cell lines, stable overexpression enhanced metastasis intravenous intraprostatic tumor xenografts....
<p>This files contains 1 Supplementary Table and 11 Figures. The shows Univariate multivariate Cox proportional hazard analysis of prostate tumor levels miR-194 Gleason score/grade in relation to recurrence-free interval after radical prostatectomy the TCGA cohort. Figures collectively include data that supports key finding this study; namely, is an important driver cancer metastasis.</p>
<div>Abstract<p>Serum levels of miR-194 have been reported to predict prostate cancer recurrence after surgery, but its functional contributions this disease not studied. Herein, it is demonstrated that a driver metastasis. Prostate tissue were associated with aggressiveness and poor outcome. Ectopic delivery stimulated migration, invasion, epithelial–mesenchymal transition in human cell lines, stable overexpression enhanced metastasis intravenous intraprostatic tumor xenografts....
<p>This files contains 1 Supplementary Table and 11 Figures. The shows Univariate multivariate Cox proportional hazard analysis of prostate tumor levels miR-194 Gleason score/grade in relation to recurrence-free interval after radical prostatectomy the TCGA cohort. Figures collectively include data that supports key finding this study; namely, is an important driver cancer metastasis.</p>
Abstract Steroid hormone signaling axes drive proliferation and survival in prostate cancer (PCa), breast other cancers. In late stage PCa, the androgen receptor (AR) is therapeutically antagonized with success, for example Enzalutamide (Enza). Although initially successful, resistance emerges associated tissue plasticity patient mortality. Enza-resistance mechanisms include altered AR coregulator interactions. Identifying which coregulators change Enza sensitivity attractive as they may...
Searchable abstracts of presentations at key conferences in oncology ISSN 2631-4657 (online)