A5091929949- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Biosensors and Analytical Detection
- Neuroscience and Neural Engineering
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Advanced Memory and Neural Computing
- Electrochemical Analysis and Applications
- Molecular Biology Techniques and Applications
- CCD and CMOS Imaging Sensors
- Advanced Biosensing Techniques and Applications
- Cell Image Analysis Techniques
Imperial College London
2023-2024
Prostate cancer (PCa) is a highly prevalent disease, causing the second largest amount of male deaths worldwide. Currently, prostate specific antigen (PSA) blood test remains standard serum prognostic and diagnostic monitoring biomarker but it lacks specificity sensitivity. PSA testing can lead to invasive biopsies which result in under detection clinically significant disease potential overtreatment indolent disease. There are promising circulating biomarkers could facilitate less more...
The COVID-19 pandemic has highlighted a significant research gap in the field of molecular diagnostics. This brought forth need for AI-based edge solutions that can provide quick diagnostic results whilst maintaining data privacy, security and high standards sensitivity specificity. paper presents novel proof-of-concept method to detect nucleic acid amplification using ISFET sensors deep learning. enables detection DNA RNA on low-cost portable lab-on-chip platform identifying infectious...
This paper presents an experimental characterisation of the pH dependence drift on ISFET sensors. Experiments are run array over 4000 sensors fabricated in commercial CMOS technology with buffer solutions known pH. A mathematical model is built and fitted coefficients compared between experiments where constant changes. An exponential a linear compared, as well different metrics for coefficient comparison. It shown that can be found variation when rate exceeds <tex...
This paper describes a method of detection for the TP53 mutation that leads to p.R248W substitution, commonly found in colorectal cancer cases. is achieved through design and implementation pH-sensitive specific Loop-mediated isothermal amplification (pH-LAMP) experimental validation using Lab-on-Chip (LoC) platform, with an integrated array Ion-Sensitive Field Effect Transistors (ISFETs) can detect pH changes. Synthetic DNA was detected pH-LAMP reactions, on both qPCR platform LoC, primers...