A5082778229- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Cancer Research and Treatments
- Adenosine and Purinergic Signaling
- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Colorectal and Anal Carcinomas
- MRI in cancer diagnosis
- Combustion and Detonation Processes
- Traumatic Ocular and Foreign Body Injuries
Institut Jules Bordet
2019-2025
Université Libre de Bruxelles
2021-2023
Vrije Universiteit Brussel
2013-2019
Universitair Ziekenhuis Brussel
2014-2018
3E (Belgium)
2017
Importance Although immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and PD-1 ligand have improved the outcome for many cancer types, majority of patients fails to respond ICI monotherapy. Hypofractionated radiotherapy has potential improve therapeutic ratio ICIs. Objective To assess addition ICIs compared with monotherapy in advanced solid tumors. Design, Setting, Participants This open-label, multicenter, randomized phase 2 trial was conducted 5 Belgian...
Abstract Background MR‐guided radiotherapy (MRgRT) offers new opportunities but also introduces workflow complexities requiring dedicated optimization. Implementing magnetic resonance linear accelerator (MR‐Linac) technology comes with challenges such as prolonged treatment times and integration issues. Purpose We present here our experience share practical tips tricks to streamline MR‐Linac implementation, optimize efficiency, improve coordination. Methods The first 150 patients treated a...
Purpose: Few data is available on rectal tumor shrinkage during preoperative chemoradiotherapy (CRT). This regression pattern interesting to optimize timing of dose escalation the tumor.Methods: Gross volumes (GTV) were contoured by two observers magnetic resonance imaging (MRI) obtained before, weekly during, 2–4 weeks after, and 7–8 after a 5-week course concomitant CRT for cancer.Results: Overall, 120 MRIs acquired in 15 patients. A statistically significant volume reduction seen from...
Dynamic Wave Arc (DWA) is a clinical approach designed to maximize the versatility of Vero SBRT system by synchronizing gantry-ring noncoplanar movement with D-MLC optimization. The purpose this study was verify delivery accuracy DWA and evaluate potential dosimetric benefits.DWA an extended form VMAT continuous varying ring position. main difference in optimization modules during angular spacing, where algorithm does not consider gantry but only Euclidian norm angle. A preclinical version...
Abstract Introduction Up to 60% of patients with metastatic melanoma develop brain metastasis ( MBM ) during the course their disease. Surgery, radiosurgery SRS ), stereotactic radiotherapy SRT and whole‐brain radiation therapy WBRT or combinations these are commonly used local treatment modalities. Inhibitory monoclonal antibodies against CTLA ‐4 PD ‐1 immune checkpoint receptors significantly improved survival patients, including . This prolonged survival, potentially also...
Abstract Background While the introduction of checkpoint inhibitors (CPIs) as standard care treatment for various tumor types has led to considerable improvements in clinical outcome, majority patients still fail respond. Preclinical data suggest that stereotactic body radiotherapy (SBRT) could work synergistically with CPIs by acting an situ cancer vaccine, thus potentially increasing response rates and prolonging disease control. Though SBRT administered concurrently been shown be safe,...
In patients diagnosed with rectal cancer, dose escalation is currently being investigated in a large number of studies. Since there little known on gross tumor volume (GTV) inter-fraction motion for wide variety margins used. Purpose this study to quantify GTV statistics different timescales and give estimates planning target (PTV) margins.Thirty-two patients, were included. To investigate from week-to-week, 16 underwent pretreatment five weekly MRIs, prior radiotherapy (RT) fraction the...
Monoclonal antibodies that block the programmed death-1 (anti-PD-1) or cytotoxic T-lymphocyte antigen-4 (CTLA-4) immune checkpoint receptors (pembrolizumab, nivolumab, ipilimumab, combination of nivolumab with ipilimumab) are approved treatment option for patients advanced melanoma. Over half all refractory to these immunotherapies and in need alternative complementary options. Talimogene laherparepvec (T-VEC) is a first-in-class intralesionally delivered oncolytic immunotherapy, which has...
Physicians considering stereotactic ablative body radiation therapy (SBRT) for the treatment of extracranial cancer targets must be aware sizeable risks normal tissue injury and hazards physical tumor miss. A first-of-its-kind SBRT platform achieves high-precision through a combination versatile real-time imaging solutions sophisticated tracking capabilities. It uses dual-diagnostic kV x-ray units stereoscopic open-loop feedback target intrafraction movement occurring as consequence...
To improve split-VMAT technique by optimizing treatment delivery time for deep-inspiration breath hold (DIBH) radiotherapy in left-sided breast cancer patients, when automatic beam-interruption devices are not available.Ten consecutive patients were treated with an eight partial arcs (8paVMAT) plan, standard of care our center. A four (4paVMAT) plan was also created and actual LINAC outputs measured, to evaluate whether there a dosimetric difference between both techniques potential impact...
Background and PurposeEvidence regarding radiation-induced lymphopenia its negative impact on oncological outcome is incrementing. Therefore, the aim of this study to evaluate feasibility lymphocyte-rich organs at risk (LOAR) sparing in pelvic irradiation for localized prostate cancer estimate effective dose circulating immune cells (EDIC).Materials MethodsTwenty patients with nodal or bed were included. The following bone marrow (BM) structures delineated as LOARs using semi-automatic...