A5021781051- French Urban and Social Studies
- PARP inhibition in cancer therapy
- Prostate Cancer Treatment and Research
- Agriculture and Rural Development Research
- DNA Repair Mechanisms
- Cancer Treatment and Pharmacology
- Healthcare Systems and Practices
- Breast Cancer Treatment Studies
- Health, Medicine and Society
- Colorectal Cancer Screening and Detection
- Clinical practice guidelines implementation
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Global Cancer Incidence and Screening
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Cancer Genomics and Diagnostics
- Frailty in Older Adults
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Nutrition and Health in Aging
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
Université Paris-Est Créteil
2012-2024
Institut Mondor de Recherche Biomédicale
2017-2024
Inserm
2013-2024
Conservatoire National des Arts et Métiers
2020-2024
AZ Sint-Lucas
2010-2023
Belgian Society of Medical Oncology
2017-2022
Paris-Est Sup
2013-2020
Universitair Ziekenhuis Leuven
2018-2019
Universitair Ziekenhuis Brussel
2019
Institut Jules Bordet
2017-2019
Importance Although immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and PD-1 ligand have improved the outcome for many cancer types, majority of patients fails to respond ICI monotherapy. Hypofractionated radiotherapy has potential improve therapeutic ratio ICIs. Objective To assess addition ICIs compared with monotherapy in advanced solid tumors. Design, Setting, Participants This open-label, multicenter, randomized phase 2 trial was conducted 5 Belgian...
Objectives To describe how general practitioners (GPs) adapted their practices to secure and maintain access care in the epidemic phase. A secondary objective was explore if GPs’ individual characteristics type of practice determined adaptation. Design Observational study using an online questionnaire. Organisational changes were measured by a main question detailed two specific outcomes. identify which impacted organisational changes, successive multivariate logistic modelling performed....
To determine the impact of physiologic changes pregnancy on pharmacokinetics chemotherapeutic agents.A preclinical and a clinical case-control trial.Institute Primate Research Nairobi collaborating hospitals in Belgium, Netherlands Czech Republic.Pregnant nonpregnant women baboons receiving chemotherapy.Chemotherapy was compared between pregnant state. Standard-dosed chemotherapy regimens were administered baboons/women, followed by serial blood samplings. Drug plasma levels determined using...
This study aimed to determine whether single nucleotide polymorphisms (SNPs) in genes involved DNA repair or metabolism of taxanes platinum could predict toxicity response first-line chemotherapy ovarian cancer. Twenty-six selected SNPs 18 were genotyped 322 patients treated with paclitaxel-carboplatin carboplatin mono-therapy. Genotypes correlated events (anemia, neutropenia, thrombocytopenia, febrile neurotoxicity), use growth factors and survival. The risk anemia was increased for variant...
A quantitative method for the simultaneous determination of docetaxel (Taxotere), paclitaxel (Taxol), 6α-hydroxypaclitaxel, and p-3'-hydroxypaclitaxel in human plasma oral fluid is developed validated. Oral (this term now preferred to saliva) was sampled with a Salivette collection device. The procedure used simple liquid/liquid extraction methyl tert-butyl ether followed by LC-ESI-MS/MS. Gradient elution applied provided increased robustness ion suppression drug formulation vehicle...
The participation rate in organized breast cancer screening France is lower than recommended. Non-participants either use opportunistic or do not modality. To assess any differences perceptions, attitudes and knowledge related to between users of non-users mammograms identify potential barriers screening. Six focus groups were conducted May 2010 with 34 French non-participants screening, 15 who used (OpS group) 19 no (NoS group). guide for both explored perceptions health, screening;...
High levels of outpatient antibiotic use remain observed in many European countries. Several studies have shown a strong relationship between and bacterial resistance.To assess the long-term effect standardised educational seminar on prescriptions by GPs.Randomised controlled trial 171 GPs (of 203 initially randomised) France.GPs control group (n = 99) received no prescription recommendation. Intervention 72) attended an interactive presenting evidence-based guidelines for respiratory...
The few studies assessing long-term effects of educational interventions on antibiotic prescription have produced conflicting results. Our aim was to assess the after 4.5 years an interactive seminar designed for GPs and focused therapy in respiratory tract infections (RTIs). expected decrease prescriptions any diagnosis. We conducted a randomized controlled parallel-group trial Paris suburb (France), with as randomization unit analysis unit. intervention occurred September 2004 final...
Several observational studies on hypertensive patients have shown a gap between therapeutic targets recommended in guidelines and those achieved daily practice. The ESCAPE trial aimed to determine whether multifaceted intervention focused general practitioners (GPs), could increase significantly the proportion of at high risk primary prevention who all their targets.A pragmatic, cluster randomized involving 257 GPs by region. group had one-day training session were given an electronic blood...
To answer the questions that arise in relation to a patient’s clinical situation, medical decisions need be made according principles of evidence-based medicine. At this time, benefits and risks glycaemic control patients with type 2 diabetes require painstaking reconsideration.1 Even if chronic hyperglycaemia is risk marker for some macro- microvascular complications, does not mean ipso facto its reduction by one or several hypoglycaemic drugs systematically beneficial from point view. The...
Abstract Background While the introduction of checkpoint inhibitors (CPIs) as standard care treatment for various tumor types has led to considerable improvements in clinical outcome, majority patients still fail respond. Preclinical data suggest that stereotactic body radiotherapy (SBRT) could work synergistically with CPIs by acting an situ cancer vaccine, thus potentially increasing response rates and prolonging disease control. Though SBRT administered concurrently been shown be safe,...
Abstract Background No study has investigated factors associated with non-participation or partial participation in the different combination patterns of screening programmes for all three cancers, that is, breast, colorectal and cervical cancer. Methods In a retrospective cohort study, we sought to describe combinations cancer rates among women Val-de-Marne area France identify individual contextual participation. Results Women aged between 50 65 who were eligible (n = 102 219) analysed...
Talazoparib has shown antitumor activity with a manageable safety profile in men metastatic castration-resistant prostate cancer (mCRPC) and DNA damage response (DDR)/homologous recombination repair (HRR) alterations.To evaluate patient-reported health-related quality of life (HRQoL) pain patients who received talazoparib the TALAPRO-1 study, special interest harboring breast susceptibility gene 1 or 2 (BRCA1/2) mutations.TALAPRO-1 is single-arm, phase study mCRPC DDR alterations either...
Background Direct oral anticoagulants (DOACs) account for an increasing proportion of prescriptions in patients with non-valvular atrial fibrillation (NVAF) primary care. Inappropriate dosing DOACs is a common problem, under-dosing being particular issue. However, conflicting results have been reported about the factors independently associated inappropriate dosing. Aim To describe among CACAO French nationwide general practice cohort, and to identify DOAC doses. Design setting...
In this opinion paper, the authors argue that extension of mandatory immunization infants up to two years age from three diseases (diphtheria, tetanus, poliomyelitis) 11 diseases, introduced in France January 2018, is not a sustainable response challenge controlling vaccine-preventable diseases. 2017, infant coverage (IC) rates were sufficiently high or increasing (hepatitis B), except for measles, mumps and rubella (MMR) meningococcus C disease. Even if vaccination obligation makes it...
Reminders have been used in various settings, but failed to produce convincing evidence of benefits on patient adherence colorectal cancer (CRC) screening. The aim this study was assess the effectiveness sending general practitioners (GPs) printed reminders about CRC We conducted a cluster-randomized controlled trial involving 144 GPs Val-de-Marne district (France), who provided care for any reason 20 778 patients eligible screening between June 2010 and November 2011. Data were collected...