A5059376978- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Effects of Radiation Exposure
- Ultrasound and Hyperthermia Applications
- Cancer Cells and Metastasis
- Cancer Risks and Factors
- Human Health and Disease
- Glutathione Transferases and Polymorphisms
- Photodynamic Therapy Research Studies
- Healthcare Systems and Public Health
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- bioluminescence and chemiluminescence research
- Lymphoma Diagnosis and Treatment
- Chemical Reactions and Isotopes
- Nutrition, Genetics, and Disease
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Endometriosis Research and Treatment
- Medical and Agricultural Research Studies
- Cancer-related molecular mechanisms research
- Advanced Radiotherapy Techniques
- Reproductive Biology and Fertility
- Biochemical Acid Research Studies
Ministry of Health of the Russian Federation
2014-2024
Medical Radiological Research Center
2015-2024
Russian Academy of Sciences
2001-2010
Academy of Medical Sciences
2010
(1) Background: There are no reliable and widely available markers of functional iron deficiency (FID) in cancer. The aim the study was to evaluate role transferrin (Tf) as a marker cancer ovary (CrO) related FID. (2) Methods: groups consisted 118 patients with CrO 69 control females. Blood serum status determined on Beckman Coulter AU (USA) analyzer. Tf quantification performed by immunoturbidimetry. relative contents apo- holo-Tf (iron-free iron-saturated Tf, respectively) were eight...
Genes encoding proteins with antioxidant properties may influence susceptibility to endometrial hyperplasia (EH) and carcinoma (ECa). Patients EH ( n = 89), concurrent ECa 76), 186), healthy controls 1110) were genotyped for five polymorphic variants in the genes involved metabolism of lipoproteins APOE Cys112Arg Arg158Cys), iron HFE Cys282Tyr His63Asp), catecholamines COMT Val158Met). matched by ethnicity (all Caucasians), age, body mass index (BMI), incidence hypertension diabetes. The...
5541 Background: Quisinostat is an orally bioavailable potent pan-histone deacetylase inhibitor. Combinations of HDAC inhibitors with paclitaxel or cisplatin demonstrate promising results in preclinical models and resistant OC. In phase Ib study the dosage combination carboplatin recommended for II was 12 mg. We report pts recurrent platinum resistantOC. Methods: main inclusion criteria tumor progression observed not less than 1 month no more 6 months after completion planned number cycles...
A review of domestic and foreign literature was carried out. Statistical analysis the available showed that at present, despite improvement screening programs around world, there is a steady increase in incidence mortality cervical cancer women reproductive age with high percentage patients advanced forms, whose proportion 32 %. The deaths during year since verification disease 2020 12.6 In structure Russian population, malignant diseases occupy second ranking place, accounting for 13.6 %...
Purpose of the study. Study characteristics human papillomavirus (HPV) infection, comparison HPV status, molecular and genetic parameters high risk (HR) with clinical morphological cervical cancer. Materials methods. The study included 240 patients morphologically verified cancer stages I–III, in whom presence DNA 14 genotypes was examined before treatment; upon detection, viral load (VL), degree integration into genome host cell were examined. Results. A number statistically significant...
Radio- and chemoresistance of cancer stem cells (CSCs) is considered as one the possible causes adverse results chemoradiotherapy for various malignancies, including cervical cancer. However, little known about quantitative changes in CSC subpopulation course treatment mechanisms individual response CSCs to therapy. The purpose study was evaluate association radiation with clinical morphological parameters disease features human papillomavirus (HPV) infection. proportion CD44+CD24low...
Purpose : To evaluate the proportion of BRCA1 / 2 mutations in patients with serous and endometrioid cancer ovary, fallopian tube, peritoneum Russia, to percentage germinal somatic mutations, identify spectrum genes, clinical morphological features BRCA-associated ovarian (OC). Patients methods The study enrolled 18 years older newly diagnosed peritoneum. Biological material (blood, tumor tissue) was collected, followed by molecular genetic analysis. method detecting blood were:...
The aim of research is to analyze available scientific data for the study relationship between carcinoma lower uterine segment and traditional prognostic factors stage 1 corpus cancer, assess its significance related treatment outcomes feasibility adjuvant radiotherapy in cases with disease poor prognosis. Search concern electronic databases use keywords analysis Russian English translated published 1987 2024. tumor occurs 3-27.8% endometrial cancer uterus body and, due anatomical features...
редставлены результаты теоретического исследования реакции окисления 1-аценафтила молекулярным кислородом. Молекулярные параметры и относительные энергии получены с использованием композитной расчетной схемы G3(MP2,CC)//B3LYP/6-311G(d,p), обеспечивающей химическую точность. Значения констант скоростей выходы продуктов были рассчитаны кинетической точностью при различных условиях в рамках теории RRKM пакетом MESS. Предложенный механизм включает себя конкурирующие пути реакции, из которых...
The article presents a clinical case of patient with stage IA endometrial cancer, who, at later date following specialized treatment conducted according to established standards, was diagnosed disease progression complicated by an abscess in the pelvic area. strategy involved radical surgical intervention, which included sanitation, resolution, and simultaneous complete cytoreduction – resection sigmoid colon, ureteral ligation, creation single-barrel colostomy, extended lymphadenectomy. A...
Распространённость вируса папилломы человека высокого канцерогенного риска при неопластических патологиях шейки маткиМкртчян Л.С., Каприн А.Д. 1 , Иванов С.А. Киселева В.И
Исследование аберраций хромосом и маркёров оксидативного стресса (малоновый диальдегид, общая антиоксидантная активность плазмы) у жительниц загрязнённых после аварии на ЧАЭС территорий
e13111 Background: First large Russian ovarian cancer observational study was conducted in 2014-2018. Methods: A total of 500 patients 29 sites Russia with newly diagnosed ovarian, peritoneal and fallopian tube enrolled (NCT02122588). The primary objective to describe treatment approaches the first line treatment. 141 (pts) BRCA1/2 mutations (BRCA1/2mt) detected by NGS blood tissue were observed prospectively during at least 2 years. Results: Rate population is high – 28.4% (141 from 496...
The antioxidant effects of lignan - 7-hydroxymatiresinol as complementary therapy for gynecological diseases Relevance. work is devoted to the study effect 7-hydroxymatairezinol in various diseases. Materials and methods. included 30 women taking (in a dose mg/day 60 days), which was conducted mini-invasive or surgical treatment. They studied general status its enzymatic link before after drug Results conclusions. Comparative analysis results showed that along with has anti-inflammatory...
Брахитерапия интраэпителиального рака влагалища (клинический случай)Кулиева Г.З., Сидорин А.В., Вербинская Н