A5064917512- Effects of Radiation Exposure
- Cancer Cells and Metastasis
- Heat shock proteins research
- Carcinogens and Genotoxicity Assessment
- Genetics, Aging, and Longevity in Model Organisms
- Cervical Cancer and HPV Research
- Chemical Reactions and Isotopes
- Radiation Therapy and Dosimetry
- Human Health and Disease
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Dendrimers and Hyperbranched Polymers
- Photodynamic Therapy Research Studies
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Nuclear Issues and Defense
- Radiopharmaceutical Chemistry and Applications
- Health, Environment, Cognitive Aging
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
Medical Radiological Research Center
2013-2024
Ministry of Health of the Russian Federation
2012-2024
Joint Institute for Nuclear Research
2022-2023
Moscow Engineering Physics Institute
2019
Academy of Medical Sciences
2006-2010
Russian Academy of Sciences
2007-2010
Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with SH3 domain Src, thereby mediating effects Hsp70 on Src Using several complementary approaches, established Hsp70-Bag3 module is broad-acting regulator cancer signaling by modulating activity transcription factors NF-κB, FoxM1, Hif1α, translation HuR, and cell-cycle regulators p21 survivin. We also identified small-molecule inhibitor, YM-1,...
Previously we have found that stationary Ehrlich ascites carcinoma (EAC) cells in vivo accumulated heat shock proteins (HSPs) and became resistant to necrotic heath induced by prolonged energy deprivation of hyperthermia. Here report apoptotic death nutrient starvation, transient ATP depletion, a microtubule‐disrupting drug, vinblastine, was also suppressed EAC comparing with exponential cells. When (sensitive) were subjected short‐term heating recovery accumulate inducible form HSP70, they...
AbstractPurpose: To determine the variant frequencies (VF) at glycophorin A (GPA) and T-cell receptor (TCR) loci in persons exposed to prolonged ionizing radiation different doses assess significance of GPA TCR assays for biodosimetry irradiation. Materials methods: The VF values were determined by means flow cytometry 120 between 1968-1996. Most exposures Chernobyl clean-up workers 1986-1987. Results: significant correlation was shown N cell frequency dose (r 0.61, p 0.0001). slope linear...
Elucidation of the mechanisms for response cancer stem cells (CSCs) to radiation exposure is considerable interest further improvement radio- and chemoradiotherapy cervical (CC). The aim this work evaluate effects fractionated on expression vimentin, which one end-stage markers epithelial-mesenchymal transition (EMT), analyze its association with CSC short-term prognosis CC patients. level vimentin was determined in HeLa, SiHa cell lines, scrapings from cervix 46 patients before treatment...
Purpose of the study. Study characteristics human papillomavirus (HPV) infection, comparison HPV status, molecular and genetic parameters high risk (HR) with clinical morphological cervical cancer. Materials methods. The study included 240 patients morphologically verified cancer stages I–III, in whom presence DNA 14 genotypes was examined before treatment; upon detection, viral load (VL), degree integration into genome host cell were examined. Results. A number statistically significant...
Understanding the effects on tumor cells underlies possible practical use of collagen- containing composition (HCCC) for treatment radiation therapy related complications. Purpose study. Is to investigate heterogeneous HCCC growth, viability, proliferative activity and stem cell pool cervical cancer in vitro. Materials methods. HeLa were incubated with commercially available HССC (trademark Sphero®GEL two versions: Medium Light) 24–72 h. We determined total number cells, their viability by...
Radio- and chemoresistance of cancer stem cells (CSCs) is considered as one the possible causes adverse results chemoradiotherapy for various malignancies, including cervical cancer. However, little known about quantitative changes in CSC subpopulation course treatment mechanisms individual response CSCs to therapy. The purpose study was evaluate association radiation with clinical morphological parameters disease features human papillomavirus (HPV) infection. proportion CD44+CD24low...