A5039570098- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Technology Assessment and Management
- Wound Healing and Treatments
- Economic and Technological Developments in Russia
- Biomedical and Engineering Education
- 3D Printing in Biomedical Research
- Periodontal Regeneration and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Spaceflight effects on biology
- Biomedical Ethics and Regulation
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Liver physiology and pathology
- Osteoarthritis Treatment and Mechanisms
- Sepsis Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Anatomy and Medical Technology
- Silk-based biomaterials and applications
- Pediatric Hepatobiliary Diseases and Treatments
- Nuclear Issues and Defense
- Radiation Therapy and Dosimetry
- Science, Research, and Medicine
Medical Radiological Research Center
2015-2025
Ministry of Health of the Russian Federation
2021-2025
Moscow Engineering Physics Institute
2022-2025
Peoples' Friendship University of Russia
2022-2025
Sechenov University
2012-2022
Moscow Institute of Physics and Technology
2012
Insufficient vascular growth in the area of artificial-material implantation contributes to ischemia, fibrosis, development bacterial infections, and tissue necrosis around graft. The purpose this study was evaluate angiogenesis after polycaprolactone microfiber scaffolds modified by a pCMV-VEGF165-plasmid rats. Influence vascularization on scaffold degradation also examined. We investigated flat microfibrous obtained electrospinning with incorporation pCMV-VEGF-165 plasmid into microfibers...
This article reports the electrospinning technique for manufacturing of multilayered scaffolds bile duct tissue engineering based on an inner layer polycaprolactone (PCL) and outer either a copolymer D,L-lactide glycolide (PLGA) or L-lactide ε-caprolactone (PLCL). A study degradation properties separate polymers showed that flat PCL samples exhibited highest resistance to hydrolysis in comparison with PLGA PLCL. Irrespective liquid-phase nature, no significant mass loss was found 140 days...
Individually customized grafts have become standard for reconstructing extensive chest wall defects resulting from surgical interventions sternal malignant neoplasms. However, the outcomes of these graft implantations can be further improved by administering patient-derived cells, which minimal oncological risks. In 2021, a 52-year-old woman with chondrosarcoma (pT2N0M0G2, stage IIB) was admitted to Department Thoracic Surgery. The patient presented large tumor in body sternum, measuring 81...
The current treatment of radiation-induced skin wounds utilizes mainly conventional therapies, including topical steroids, creams, ointments, and hydrogel dressings, which do not take into account the immunologic changes that occur in after radiation exposure. Therefore, it is relevant to consider alternative therapies their impact on immune landscape skin. aim this study was investigate effect allogeneic minimally manipulated keratinocytes fibroblasts rat repair development responses. We...
Background Clinical observations demonstrated that COVID-19 related pneumonia is often accompanied by hematological and coagulation abnormalities including lymphopenia, thrombocytopenia, prolonged prothrombin time. The evaluation of laboratory findings inflammation parameters may represent a promising approach for early determination severity.
Objective Implantation of tissue-engineered tracheal grafts represents a visionary strategy for the reconstruction wall defects after resections and may develop into last chance number patients with severe cicatricial stenosis. The use decellularized substrate would offer an ideally stiff graft, but matrix density challenge efficient remodeling living cartilage. In this study, we hypothesized that pores laser-perforated cartilage (LPTC) tissues can be colonized by adult nasal chondrocytes...
Immune responses to tissue-engineered grafts made of xenogeneic materials remain poorly studied. The scope current investigations is limited by the lack information on orthotopically implanted grafts. A deeper understanding these processes great importance since innovative surgical approaches include implantation decellularized scaffolds seeded cells. purpose our work study immunological features tracheal repair during constructs based human modified via laser radiation in rabbits. samples...
We’ve read with great interest the article by Smolinska et al. entitled “Stem Cells and Their Derivatives: An Implication for Regeneration of Nonunion Fractures” regarding recent scientific studies dealing treatment nonunion fractures in clinical preclinical settings using Mesenchymal Stem Cell (MSC)-based therapeutic techniques. Bone tissue regeneration is a dynamic process that involves restoration damaged or lost bone structure function. Traditional approaches such as autografts...
Abstract A growing number of studies report dermal malignancies mimicking diabetic foot ulcers (DFUs). We reviewed clinical cases reporting malignant tumours misdiagnosed to be DFU aiming identify factors contributing misdiagnosis. systematically searched in PubMed for on misdiagnosis patients with cancer. chi‐square analysis was conducted show the link between incidence initial and patient age, gender wound duration. Lesions were subsequently diagnosed as melanoma (68% cases), Kaposi's...
Infertility is an important personal and society disease, of which the male factor represents half all causes. One aspects less studied in infertility immunological testicular microenvironment. Mast cells (MCs), having high potential for regulating spermatogenesis due to fine-tuning state integrative buffer metabolic environment, are one most crucial cellular subpopulations interstitium. component MC secretome proteases that can act as proinflammatory agents extracellular matrix (ECM)...
Soft gingival tissue deficiency remains a severe problem leading to postoperative recession, peri-implantitis, and bone resorption. The use of collagen matrices does not always lead complete rebuilding the gingiva volume. application mesenchymal stromal cells (MSCs) simultaneously with materials represents promising approach for restoration soft tissues. However, short-term effects MSCs-enriched grafts after augmentation have yet been studied properly. Mucograft Mucoderm were implanted in...