A5006894254- Renal cell carcinoma treatment
- Renal and related cancers
- Mast cells and histamine
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Healthcare Systems and Public Health
- Pituitary Gland Disorders and Treatments
- Sperm and Testicular Function
- Pediatric Urology and Nephrology Studies
- Adrenal and Paraganglionic Tumors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Coronary Artery Anomalies
- Soft tissue tumor case studies
- Skin and Cellular Biology Research
- Cancer, Hypoxia, and Metabolism
- Hydrogen's biological and therapeutic effects
- Bladder and Urothelial Cancer Treatments
- Ultrasound in Clinical Applications
- Cardiovascular Issues in Pregnancy
- Chemotherapy-induced cardiotoxicity and mitigation
- Urinary Bladder and Prostate Research
- Food Allergy and Anaphylaxis Research
- Urinary Tract Infections Management
- Testicular diseases and treatments
- Chemical Reactions and Isotopes
City Clinical Hospital
2024-2025
Russian New University
2019-2024
Peoples' Friendship University of Russia
2014-2024
Ministry of Health of the Russian Federation
2019-2024
Scientific Research Institute of Healthcare Organization and Medical Management
2024
Moscow State University of Medicine and Dentistry
2019
Introduction. Cancer occupies one of the leading positions in list most common death causes world. The widespread use chemo-, targeted, immune and radiation therapy clinical practice has increased survival cancer patients. However, incidence cardiotoxic complications antitumor significantly, they may manifest themselves many years after onset remission. Brief description. We present a case premature coronary artery disease (CAD) 40-year-old male patient, who underwent multiagent chemotherapy...
// P.A. Shatalov 1 , N.A. Falaleeva E.A. Bykova D.O. Korostin 2 V.A. Belova A.A. Zabolotneva A.P. Shinkarkina A. Yu Gorbachev 3 M.B. Potievskiy V.S. Surkova Zh V. Khailova Kulemin Denis Baranovskii 4 Kostin A.D. Kaprin and P.V. Shegai National Medical Research Radiological Centre of the Ministry Health Russian Federation, Obninsk 249036, Russia Center for Precision Genome Editing Genetic Technologies Biomedicine, Pirogov University, Moscow 117997, FSBI "Lopukhin Federal Clinical...
The mechanisms of the pathogenesis neck paraganglioma (PGL) and possible role mast cells (MCs) in its development metastasis are still poorly understood. We analyzed MCs' morphologic characterization, activation, properties their cytoplasmic/released granules PGLs, using light transmission electron microscopy. Paragangliomas showed a large tumor-associated MC population both connective tissue layers tumor between cells. Notably, MCs were presented by high expression specific proteases, size...
Infertility is an important personal and society disease, of which the male factor represents half all causes. One aspects less studied in infertility immunological testicular microenvironment. Mast cells (MCs), having high potential for regulating spermatogenesis due to fine-tuning state integrative buffer metabolic environment, are one most crucial cellular subpopulations interstitium. component MC secretome proteases that can act as proinflammatory agents extracellular matrix (ECM)...
Chronic kidney disease is detected in 8-15% of the world's population. Along with fibrotic changes, it can lead to a complete loss organ function. Therefore, better understanding onset pathological process required. To address this issue, we examined interaction between mast cells (MCs) and fibrous intact regions, focusing on role MC proteases such as tryptase, chymase, carboxypeptidase A3 (CPA3). MCs appear be involved development inflammatory changes through targeted secretion CPA3...
Marfan syndrome (MFS) is a hereditary condition accompanied by disorders in the structural and regulatory properties of connective tissue, including elastic fibers, due to mutation gene encodes for fibrillin-1 protein (FBN1 gene) synthesis abnormal glycoprotein. Despite high potential mast cells (MCs) remodel extracellular matrix (ECM), their pathogenetic significance MFS has not been considered yet. The group patients with included two mothers five children (three girls aged 4, 11, 11 boys...
Background . Spontaneous coronary artery dissection (SCAD) is an underdiagnosed and rare cause of myocardial infarction (MI). SCAD defined as the separation wall by hemorrhage with or without intimal tear. It causes acute syndrome in 1.7% to 4% cases. Case Summary We report a case patient MI caused marked progression within 4 days spontaneous healing 2 months. Fibromuscular dysplasia (FMD) arteries associated condition that was found our patient. Conclusion In young women admitted clinic...
The tuberculosis is the most important medical and social problem among globally dangerous epidemiological phenomena. ranks 9th place in structure of mortality disability population 1st causes death from single infectious agent.The purpose study was to analyze dynamics total morbidity because against background implementation telemedicine clinical organizational technology phthisiology care 2007-2021.The official Regional Federal data Rosstat for 2007-2021 were used. indicators caused by...
Molecular hydrogen (H2) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced hypertension (MPH), we had previously explored the impact of inhaled H2 on lung inflammation blood pressure. this study, further focused biological effects mast cells (MCs) parameters phenotype local tissue microenvironment. MPH resulted in significantly increased number MCs both pneumatic respiratory parts lungs, an...
Background . The generally algorithm for the initial physical examination of patients with STEMI, including medical history and ECG, is inadequate. Short focal ultrasound protocols can improve diagnostic accuracy examination, but when they are needed, there currently no clear understandable algorithms. Objective Evaluate impact routine on STEMI patients. Material methods A total 228 were included in a single-center prospective cohort study. will be enrolled at I.V. Davydovsky Moscow City...
The problem of timely final diagnosis, early initiation treatment and optimal management patients with malignant neoplasms is very actual. purpose the study to analyze experience managing in largest private medical organization. sociological survey 412 oncologists, surgeons, including coloproctologists obstetrician-gynecologists working clinics Medsi Group Companies Moscow Oblast was carried out. In 2023, all functioning Russia, after establishment diagnosis neoplasm, 45.7% these continued...
Introduction . Nowadays the standard of care for locally advanced and metastatic urothelial carcinoma (UC) is a combination platinum-based drugs. However, such therapy characterized with high toxicity selective efficacy. So, question optimal alternative to first line choice drugs second currently relevant. Immune checkpoint inhibitors have revolutionized treatment UC. Nevertheless, despite fact that initially this series showed fairly efficacy as second-line UC, at present there no...
ПРОГНОСТИЧЕСКАЯ ЦЕННОСТЬ ПЭТ/КТ С 18F-ФДГ В ОПРЕДЕЛЕНИИ СТАТУСА МУТАЦИИ ГЕНА EGFR У ПАЦИЕНТОВ НЕМЕЛКОКЛЕТОЧНЫМ РАКОМ ЛЕГКОГО
A solitary fibrous tumor (SFT) are rare mesenchymal neoplasms and due to the fact of their low occurrence, there no large-scale researches this nosology today. The article describes report 37‑year old woman with case kidney. laparoscopic radical right nephrectomy was performed. Histological immunological studies revealed a patient did well postoperatively remains disease-free at present time.
The possibilities and technique of using the radioactive colloid technetium99mTc “Tehnefit 99mTc” to identify 35 biopsy sentinel lymph nodes with their morphological examination during operations in patients early breast cancer melanoma were studied. optimal dosage active volume features injection for “Technetium99mTc” best results Trial № 1 was determined. most reliable histological cytological intraoperative diagnosis metastases a combination both methods. Trials did not display same that...
Acute pyelonephritis belongs to the wide-spread inflammatory diseases in oncourological inpatient clinic. Escherichia coli continues be leading causal agent of urinary tract infections. Obstructive uropathies (including bladder tumours), foreign bodies, vesico-ureteral reflux contribute ascending development infection. The choice antimicrobial drug majority cases is done speculatively, on basis data about domineering causative agents and their regional resistance. In case complicated...
.