А. О. Толкачев

ORCID: 0000-0002-8630-6072
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About
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Research Areas
  • Cancer, Hypoxia, and Metabolism
  • Adrenal and Paraganglionic Tumors
  • Testicular diseases and treatments
  • Renal cell carcinoma treatment
  • Healthcare Systems and Public Health
  • Sexual Differentiation and Disorders
  • Genital Health and Disease
  • Pediatric Urology and Nephrology Studies
  • Hormonal Regulation and Hypertension
  • Sexual function and dysfunction studies
  • Prostate Cancer Treatment and Research
  • Ovarian cancer diagnosis and treatment
  • IgG4-Related and Inflammatory Diseases
  • Infrared Thermography in Medicine
  • Cardiovascular Disease and Adiposity
  • Renal and related cancers
  • Genetic and Kidney Cyst Diseases
  • Radiopharmaceutical Chemistry and Applications
  • Chemical Reactions and Isotopes
  • Sperm and Testicular Function
  • Biomarkers in Disease Mechanisms
  • Pituitary Gland Disorders and Treatments
  • Soft tissue tumor case studies

Ministry of Health
2018-2024

Ministry of Health of the Russian Federation
2020-2024

National Medical Research Center of Cardiology
2024

P.A. Hertzen Moscow Oncology Research Institute
2020

Among the main methods of prostate cancer diagnosing, such as finger rectal examination, prostate-specific antigen test, ultrasound examination prostate, none them possesses enough specificity and sensitivity. In our research, we used special statistic mathematic processing (multifactor analysis binary logic regression) symptoms, which allows to suspect with 97% accuracy also reduce frequency unnecessary biopsies prostate.

10.5958/0974-360x.2017.00130.5 article EN Research Journal of Pharmacy and Technology 2017-01-01

ФГБУ «Национальный

10.17709/2409-2231-2016-3-4-2 article RU cc-by Research and Practical Medicine Journal 2016-01-01

Introduction. Testicular cancer (TC) mostly affect young men of reproductive age. Several studies have shown correlation between the level sex hormones in testicular and serum tumor markers. However, currently, relationship hormone levels before orchidectomy clinical pathomorphological characteristics has not been sufficiently studied. Aim study: to analyze stage histological patients with develop prognostic models. Material Methods. This prospective single-center study included 66 cancer....

10.21294/1814-4861-2024-23-1-63-74 article EN cc-by Siberian Journal of Oncology 2024-03-23

Introduction. The hypothalamic-pituitary-gonadal axis (HPG) is the most important part of hormonal system that controls testicular function in men. It known neoplasms (TN) can disrupt regulation HPG due to occurrence imbalance. However, changes patients with TN have been little studied, especially before start treatment. Aim: assess degree disorders affecting men Material and methods. study included 49 newly diagnosed TN. concentration total testosterone (T), free (cT), estradiol (E2),...

10.29188/2222-8543-2024-17-1-68-74 article EN cc-by Experimental and Сlinical Urology 2024-03-25

Introduction. Testicular neoplasms (TN) are one of the most common oncological diseases among young men. Currently sexual function such patients remains understudied. The aim study was to assess state in men with testicular before treatment. Material and methods. cross-sectional continuous single-center included 35 TN. average age 34.2–8.2 years (95% CI: 31.4-37.1). comparison group 28 healthy volunteers, 30.5–4.9 28.6-32.4). Some social characteristics patient (marriage children), (using...

10.62968/2070-9781-2024-25-2-109-118 article EN cc-by Andrology and Genital Surgery 2024-01-01

Introduction. Testicular neoplasms (TN) are one of the most common oncological diseases among young men. Currently sexual function such patients remains understudied. The aim study was to assess state in men with testicular before treatment. Material and methods. cross-sectional continuous single-center included 35 TN. average age 34.2–8.2 years (95% CI: 31.4-37.1). comparison group 28 healthy volunteers, 30.5–4.9 28.6-32.4). Some social characteristics patient (marriage children), (using...

10.62968/2070-9781-2024-25-2-110-119 article EN cc-by Andrology and Genital Surgery 2024-07-04

Patients with castration-refractory prostate cancer (PC) are a complicated group of patients for treatment. At the time diagnosis, 85% have localized tumor process, however, in 40% patients, generalization process is observed. The most common localization metastasis skeletal bone, which affects up to 90% cases. same time, taking into account increase morbidity pathology, it dictates need search new, more effective methods treatment this patients. Currently, there six metastatic (mCRPC):...

10.17709/2409-2231-2017-4-4-9 article EN cc-by Research and Practical Medicine Journal 2017-01-01

A solitary fibrous tumor (SFT) are rare mesenchymal neoplasms and due to the fact of their low occurrence, there no large-scale researches this nosology today. The article describes report 37‑year old woman with case kidney. laparoscopic radical right nephrectomy was performed. Histological immunological studies revealed a patient did well postoperatively remains disease-free at present time.

10.17709/2409-2231-2014-1-1-74-79 article EN cc-by Research and Practical Medicine Journal 2015-01-16

Background . Surgical treatment of solitary and oligometastatic metastases in renal cell carcinoma (RCC) is one the options for modern oncology. The objective study to compare surgical outcomes synchronous metachronous metastatic adrenal tumors RCC. Materials methods included 93 patients with kidney cancer, from 1997 till 2018, who underwent urological oncology department P.A. Hertzen Moscow Oncology Research Institute. 1st group represented by 58 RCC secondary gland lesion, simultaneous...

10.17650/1726-9776-2019-15-4-50-57 article EN Cancer Urology 2020-01-16

Сращение почек — одна из наиболее распространенных почечных аномалий. Чаще всего встречается подковообразная почка, которая характеризуется сращением полюсов органа, как правило нижних. Нами описан клинический случай злокачественной опухоли в правой половине подковообразной почки (рак I стадии cT1aN0M0) у мужчины 65 лет, которому была выполнена лапароскопическая резекция. Было показано, что лапароскопия является не менее эффективным методом, чем открытое хирургическое вмешательство. Однако...

10.24075/brsmu.2016-02-08 article RU cc-by Bulletin of Russian State Medical University 2016-01-01

The following methods are usually used for evaluation of adrenal lesion: computed tomography, magnetic resonance imaging, 18F-fluorodeoxyglucose positron emission tomography/computed tomography and sometimes 123I-meta-iodobenzylguanidine scintigraphy. Malignant tumors, such as adrenocortical carcinoma malignant pheochromocytoma, appear to have particularly aggressive course, which leads high mortality rate among these patients, especially in the later stages disease. Thus, there is a...

10.17650/2070-9781-2016-17-4-38-43 article EN cc-by Andrology and Genital Surgery 2016-01-01

Purpose. To investigate the effect of development erectile dysfunction (ED) in patients with prostate cancer after radical prostatectomy (RPE) on assessment these patients’ quality life and their psychological state influence parameters ED treatment by implantation prosthesis penis. Materials methods. The material study was analysis questionnaire data 30 PC postoperative before period falloprosthesis. In long-term (2–3 years) ( n = 30) an stand, who wanted to restore sexual function, were...

10.17709/2409-2231-2018-5-2-6 article EN cc-by Research and Practical Medicine Journal 2018-06-08

Background . Adrenal glands are the site of solitary synchronous and metachronous metastases in non-small cell lung cancer (NSCLC). The presence adrenal metastasis from provides survival benefit; however, currently, there no exact treatment algorithms. Objectives study : to assess shortand long-term outcomes patients with NSCLC. Material methods Treatment undergoing adrenalectomy for NSCLC were analyzed. Results From 1993 2014, 13 (11 males/2 females aged between 44 78, median age 58 years)...

10.21294/1814-4861-2020-19-4-105-111 article EN cc-by Siberian Journal of Oncology 2020-09-02
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