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Dysferlinopathy represents an orphan disease within the spectrum of progressive muscular dystrophies, occurring at a frequency 1 to 9 cases per 1.000.000 individuals (Orphanet, 2024). It arises from mutations in DYSF gene (OMIM 603009, 2p13, NM_003494.4), which is responsible for coding transmembrane protein dysferlin. Dysferlin plays critical role repair muscle fiber membranes and cellular processes skeletal regeneration. Although molecular mechanisms dysferlin-mediated are under active...

Background. The continued importance of addressing the issue treating purulent wounds and surgical infections different origins localization against background increased resistance their main pathogens dictates need to develop alternative protocols search for new treatment strategies, effectiveness which is confirmed by objective diagnostic methods. Objective. aim study was analyze phage therapy in comparison with traditional methods local drug systemic comorbid patients infection various...

Objective. To analyze long-term structural and functional changes of connective tissue in patients with recurrent hernias after repair implants. Material methods. Excisional biopsies from the hernia recurrence sites were performed 60 who had previously undergone In 37 (62%) patients, polypropylene mesh unidentified manufacturer was implanted. Eight (13%) underwent PROLENE implantation, 4 (5%) — Ultrapro partially absorbable lightweight composed approximately equal parts non-absorbable fibers...

An experimental model of an infected wound was created in 90 Wistar rats using a mixture cultures Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans . The animals are divided into 3 groups 30 individuals. first group consisted treated with pulsed high-intensity broadband irradiation apparatus xenon lamp operating periodic mode average UV-C (200-280 nm) radiation power W, 24 kW. In the second group, traditional ultraviolet wounds mercury bactericidal...

Infertility is an important personal and society disease, of which the male factor represents half all causes. One aspects less studied in infertility immunological testicular microenvironment. Mast cells (MCs), having high potential for regulating spermatogenesis due to fine-tuning state integrative buffer metabolic environment, are one most crucial cellular subpopulations interstitium. component MC secretome proteases that can act as proinflammatory agents extracellular matrix (ECM)...

Chronic kidney disease is detected in 8-15% of the world's population. Along with fibrotic changes, it can lead to a complete loss organ function. Therefore, better understanding onset pathological process required. To address this issue, we examined interaction between mast cells (MCs) and fibrous intact regions, focusing on role MC proteases such as tryptase, chymase, carboxypeptidase A3 (CPA3). MCs appear be involved development inflammatory changes through targeted secretion CPA3...

The objective of this study was to investigate the effectiveness high-intensity pulsed broadband irradiation in treating infected wounds. A morphological conducted on wound specimens from 105 Wistar rats, which wounds were experimentally induced (three groups). first group treated with irradiation, second received traditional ultraviolet and third only antiseptics. Monitoring performed before treatment, 7th, 14th, 21st days treatment. Non-parametric statistical methods used for data analysis....

МОРФОЛОГИЧЕСКАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ ПРИМЕНЕНИЯ ГИДРОХИРУРГИЧЕСКОЙ СИСТЕМЫ VERSAJET ® В СОЧЕТАНИИ С КОМБИНИРОВАННОЙ АНТИБАКТЕРИАЛЬНОЙ ТЕРАПИЕЙ ПРИ ЛЕЧЕНИИ ГНОЙНО-НЕКРОТИЧЕСКИХ ОСЛОЖНЕНИЙ СИНДРОМА ДИАБЕТИЧЕСКОЙ СТОПЫ БИОПЛЕНОЧНЫМИ ФОРМАМИ БАКТЕРИЙ

The aim of the study was features ultrastructural changes in cellular elements and connective tissue carcass great saphenous vein (GSV) at varicose disease depending on duration persons different ages. An examination by light microscopy 133 fragments BPV, excised during phlebectomy 19 patients, an electron microscopic 532 preparations were performed. Depending age four groups distinguished: 18-44 years old (young people); 45-59 (middle-aged 60-74 (the elderly), 75-90 (persons senile age). In...

Оригинальные исследОвания Экспериментальная медицина Р аны различного происхождения являются одной из самых распространенных хирургических патологий [1, 2]. Среди множества различных препаратов и немедикаментозных средств свою нишу занимает лазерное излу-

In the paper study of molecular disorder genes c-Myc and N-Myc in solid-pseudopapillary tumor pancreas. Examined 24 samples tumors obtained from 21 patients, including 19 primary, recurrent 1, 4 metastasis. Fluorescence situ hybridization was performed using DNA lokusspetsificheskih to loci 2p24, 6q23, 8q24 company «Vysis, Abbott Laboratories Inc», demonstrated that amplification gene can be another confirming its neurogenic origin.

A number of sarcolemma proteins are responsible for muscle fiber repair. Dysferlin encoded by the DYSF gene is one these proteins. promotes membrane repair in striated fibers (MFs). Mutations lead to loss or decreased dysferlin expression, impaired MF, and its destruction, clinically manifesting as dysferlinopathy. Preclinical studies cell therapies aimed at restoring regeneration require well-characterized small animal models. Our investigation distinguish histopathological features a mouse...

To develop new technique of abdominal wall repair for postoperative ventral hernia without disadvantages which are intrinsic open and laparoscopic surgery.Combined was used in 18 patients with hernia. Open stage provided safe dissection adhesions defect closure by autoplasty, procedure consisted prosthesis deployment separation layers. Two types composite endoprostheses anti-adhesive coating were repair.There no cases recurrence or infectious complications long-term period (from 3 to 106...

Structural and functional analysis of cells from purulent-necrotic wounds in patients with diabetic foot syndrome undergoing ultrasonic treatment 0.2% Lavasept solution.It is presented morphological/ultrastructural wound specimens 90 (DFS) aged 27-80 years complications who were hospitalized the department infections Vishnevsky Institute Surgery 2013-2016. Main group consisted 75 patients, control - 15 patients. Mean age was 58.4±8.2 years. All had diabetes mellitus type II for previous...

To define the optimal treatment of postoperative ventral hernias.It was performed microscopic examination intraoperative specimens which were obtained from 40 patients with medium, large and giant hernia. The aim to reveal ultrastructural changes morphological features are associated abdominal wall weakness in case There 28 (70%) cases primary hernia 12 (30%) recurrent multiple-recurrent In 4 polypropylene mesh implants implanted prior recurrence. Tissue top herniation, hernial ring 6 cm...

BACKROUND: The development of capillaries in human embryogenesis is a multi-stage process influenced by genetic factors and signaling pathways, which interest studying the mechanisms vascular bed formation prenatal period development. AIM: To study embryonic early fetal periods determine morphological prere­quisites leading to developmental defects. MATERIAL AND METHODS: biomaterial 50 embryos fetuses from 4 12 weeks was studied. A histological electron microscopic examination specimens...

Nowadays, the palm of superiority in elective surgery belongs to problem hernias. According literature worldwide, more than 20 million patients undergo surgical treatment for hernia anterior abdominal wall every year, most whom alloplasty using various kinds nets. The study influence methods fixing implants and emerging local inflammatory response tissues on frequency relapses after allognioplasty is devoted isolated works. Aim was investigate an experiment characteristics reaction when...

From the modern standpoint of theoretical histology, term "histione" is commonly understood to mean a temporary or permanent cellular association, whose combined functional activity aimed at achieving significant structural and other types homeostasis. The model concept histione can be successfully applied analyze structure, function their disorders, including characterizing so- called intestinal epithelial barrier. available scientific data indicate involvement increased permeability...

<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Определение объективных критериев влияния терапии обогащенной тромбоцитами аутологичной плазмой (platelet-rich plasma — PRP; синоним богатая плазма (БоТП)) на качество кожи шеи основании клинических и морфологических показателей. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> Четырем пациенткам в область 1 раз 4 нед трижды вводили по 2,5 мл PRP справа физиологического раствора слева. Результаты оценивали через 2 после окончания курса инъекций с помощью (фотопротоколирование, оценка...

Казанский (Приволжский) федеральный университет, г.Казань, Российская Федерация (1) Институт хирургии им.А.В.Вишневского, г.Москва, (2) Рязанский государственный медицинский университет имени академика И

The aging process of the skin hand continuously progresses from mature to advanced age. With age, becomes pigmented, dry, wrinkled with an emphasized pattern, tone decreases, thinning and atrophy adipose tissue are noted, elasticity is lost formation excess hypoelastic thinned dermis. In recent years, smooth thread implants have been used correct involutional changes in back hand. aim study was a morphological evaluation effectiveness correction surface based on polycaprolactone...