A5059284262- Human Health and Disease
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Healthcare Systems and Public Health
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nephrotoxicity and Medicinal Plants
- Lipoproteins and Cardiovascular Health
- Iron Metabolism and Disorders
- Urban Transport Systems Analysis
- Mast cells and histamine
- Neonatal Health and Biochemistry
- Biochemical effects in animals
- Complement system in diseases
- Digestive system and related health
- Coastal Management and Development
- Climate Change and Health Impacts
- Neurological Disorders and Treatments
- Medicinal Plants and Bioactive Compounds
Orenburg State Medical Academy
2019-2024
Institute of Economic Research of the Slovak Academy of Sciences
2021
Chronic kidney disease is detected in 8-15% of the world's population. Along with fibrotic changes, it can lead to a complete loss organ function. Therefore, better understanding onset pathological process required. To address this issue, we examined interaction between mast cells (MCs) and fibrous intact regions, focusing on role MC proteases such as tryptase, chymase, carboxypeptidase A3 (CPA3). MCs appear be involved development inflammatory changes through targeted secretion CPA3...
The goal is to discuss the criteria for early diagnosis of chronic kidney disease (CKD) in children. article presents data from modern literature on epidemiology, classification, and CKD, own scientific results clinical paraclinical characteristics CKD regional children Orenburg region. Modern approaches children, identification risk factors progression nephropathy algorithm childhood, taking into account unfavorable factors, are scientifically substantiated. A set measures prevention a...
The use of biomarkers formation kidney pathology in obesity by evaluation the level lipid and carbohydrate metabolism, insulin resistance, serum leptin adiponectin is promising for early diagnosis renal lesions children [1–4]. Direct impact adipocytokines produced adipose tissue, may be cause structural functional abnormalities [5,6].
The article presents current information on the pathogenetic role of lipid metabolism disorders and value lipotoxicity in renal pathology, contributing to progression nephropathy. detected increase cholesterol level, TAG, LDL, decrease plasma HDL concentration chronic kidney disease (CKD) is accompanied by significant changes composition various lipoproteins caused expression activity key proteins enzymes involved biosynthesis, transport, remodeling catabolism lipids lipoproteins. It has...
Цель. Определить биомаркеры ранней диагностики и прогнозирования течения различных вариантов тубулоинтерстициальной болезни почек (ТИБП) у детей. Материалы методы. Проведено клинико-параклиническое обследование проспективное наблюдение 120 детей с ТИБП 30 контрольной группы в возрасте от 1 года до 17 лет. Выделены пациенты 1-й – без признаков ХБП (n=50); 2-й формированием (n=70). Статистическая обработка материала произведена использованием программы Statistica 10.0. Результаты. При...
It is proved that HUS in children the cause of formation and progression renal dysfunction with CKD. At same time, outcomes childhood remain insufficiently studied. Purpose. To establish hemolytic-uremic syndrome to develop an algorithm for their prediction.Results. Seasonality established (May June) children, increase incidence rate. In structure Orenburg region, STEC-HUS prevails (96.5 %), more often (68.6 %) infants young children. Chronic kidney diseases associated are characterized by a...
The article presents an analysis of fundamental data on the problem stress and its role in development stressful diseases. Scientific evidence childhood pathology indicates extreme pathogenetic significance stress. It is proved that has three interconnected faces: as a link adaptation mechanism, pathogenesis diseases to situations natural prevention scientific substantiation main evolutionarily determined possibility acquiring some degree resistance situations. Prevention reducing excess...
The authors present their own results of scientific research on the clinical and paraclinical characteristics various stages chronic kidney disease in children. They determine pathogenetic markers for diagnosis prognosis childhood with assessment set endothelial dysfunction markers. proved diagnostic prognostic value a stepwise increase arterial hypertension, urinary excretion prosclerotic, pro-inflammatory cytokines growth factors simultaneous decrease anti-inflammatory cytokines, an level...
Modern scientific data and the emergence of new opportunities for development pediatrics nephrology are inextricably linked with medical genetics, role which is especially important understanding etiology pathogenesis many diseases urinary system. In 35–80 % children diffuse connective tissue diseases, kidney damage formed, one leading causes comorbidity pathology mortality patients. genetic research will allow not only to decipher nature but also scientifically substantiate adequate...
Introduction. The term «chronic kidney disease» (CKD) is used to define the outcomes of various forms chronic progressive disease, characterized by damage, or a decrease in their function for three months more, regardless nosological diagnosis. aim work was determine frequency, structure, and clinical paraclinical features CKD children substantiate principles its management primary health care. Results. In patients, tubulointerstitial renal lesions were established prevail (80%). Associated...
Indonesia is located on the archipelago, which consists of more than 17800 islands. This fact largely determined a structure transport system country. The Indonesian Central government's spending has increased significantly in recent years (before 2020). allowed country to expand its network and improve access remote areas archipelago.
 Maritime navigation provides link between different parts On some islands, where there are no good roads, main connection via large rivers. most...
НАУЧНАЯ ШКОЛА КАР ЛА ПЮДВИГА И ЕЕ ВКЛАД В РАЗВИТИЕ ФИЗИОЛОГИИ МЕДИЦИНЫ 19 СТОЛЕТИИ Ha протяжении второй половины Х|Х в. в физиологической науке произошел коренной сдвиг сторону ускорения ее развития.Используя термин Т.Куна П