A5089093250- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- HER2/EGFR in Cancer Research
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Palliative Care and End-of-Life Issues
- Breast Lesions and Carcinomas
- Cancer-related cognitive impairment studies
- Pain Management and Opioid Use
- Monoclonal and Polyclonal Antibodies Research
- DNA Repair Mechanisms
- Fibroblast Growth Factor Research
- Neutropenia and Cancer Infections
Universitair Ziekenhuis Brussel
2012-2024
Breast International Group
2024
Vrije Universiteit Brussel
2008-2022
Belgian Society of Medical Oncology
2009-2022
Institut Jules Bordet
2017-2019
Universitair Ziekenhuis Leuven
2019
Catholic University of America
2012
Europe Hospitals
2012
Catharina Ziekenhuis
2010
Ziekenhuis Bernhoven
2010
Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor characteristics in breast cancer to guide therapy. Anti-HER2 treatment has clear survival advantages HER2-positive carcinoma patients. Heterogeneity HER2 expression between primary and metastasis repeatedly been described, resulting need reassess during disease course. To avoid repeated biopsy with potential bias due heterogeneity, Nanobodies directed against have developed as probes for molecular imaging....
Human epidermal growth factor receptor 2 (HER2) status is used for decision-making in breast carcinoma treatment. The obtained through immunohistochemistry or situ hybridization. These two methods have the disadvantage of necessitating tissue sampling, which prone to error due tumor heterogeneity interobserver variability. Whole-body imaging might be a solution map HER2 expression throughout body. <b>Methods:</b> Twenty patients with locally advanced metastatic (5 HER2-positive and 15...
<sup>131</sup>I-GMIB-anti-human epidermal growth factor receptor type 2 (HER2)-VHH1 is a targeted radionuclide theranostic agent directed at HER2-expressing cancers. VHH1 single-domain antibody covalently linked to therapeutic <sup>131</sup>I via the linker <i>N</i>-succinimidyl 4-guanidino-methyl-3-iodobenzoate (SGMIB). The phase I study was aimed evaluating safety, biodistribution, radiation dosimetry, and tumor-imaging potential of <sup>131</sup>I-GMIB-anti-HER2-VHH1 in healthy volunteers...
Patients with triple-negative breast cancer (TNBC) who relapse early after (neo)adjuvant chemotherapy have more aggressive disease. In the ASCENT trial, sacituzumab govitecan (SG), an antibody-drug conjugate composed of anti-Trop-2 antibody coupled to SN-38 via a hydrolyzable linker, improved outcomes over single-agent physician's choice (TPC) in metastatic TNBC (mTNBC). Of 468 patients without known baseline brain metastases, 33/235 vs 32/233 (both 14%) SG TPC arms, respectively, received...
Macrophages play an important role throughout the body. Antiinflammatory macrophages expressing macrophage mannose receptor (MMR, CD206) are involved in disease development, ranging from oncology to atherosclerosis and rheumatoid arthritis. [
Cancer seems to have an independent adverse prognostic effect on COVID-19-related mortality, but uncertainty exists regarding its across different patient subgroups. We report a population-based analysis of patients hospitalised with COVID-19 prior or current solid cancer versus those without cancer.We analysed data adult registered until 24 May 2020 in the Belgian nationwide database Sciensano. The primary objective was in-hospital mortality within 30 days diagnosis among cancer. Severe...
Pain after cancer remains underestimated and undertreated. Precision medicine is a recent concept that refers to the ability classify patients into subgroups differ in their susceptibility to, biology, or prognosis of particular disease, response specific treatment, thus tailor treatment individual patient characteristics. Applying this pain cancer, post-cancer three major phenotypes (i.e. nociceptive, neuropathic, nociplastic pain) accordingly, an emerging issue. This especially relevant...
In the majority of familial breast cancer (BC) families, etiology disease remains unresolved. To identify missing BC heritability resulting from relatively rare variants (minor allele frequency ≤ 1%), we have performed whole exome sequencing followed by variant analysis in a virtual panel 492 cancer-associated genes on patients BRCA1 and BRCA2 negative families with elevated risk.BC 54 BRCA2-negative risk 120 matched controls were considered for germline DNA sequencing. Rare identified [492...
PURPOSE: To assess whether the addition of epirubicin (EPI) therapy to prolonged treatment with tamoxifen (TAM) improves relapse-free and overall survival in postmenopausal women node-positive primary breast cancer. PATIENTS AND METHODS: Six hundred four patients entered onto a randomized clinical trial were allocated receive TAM 20 mg/d for 4 years or plus EPI 50 mg/m 2 intravenously on days 1 8 every weeks six cycles. Analysis was performed according treatment, all included (intention...
Recently aromatase inhibitors have become a standard care as an adjuvant treatment for many postmenopausal patients with hormone receptor positive early breast cancer. Adjuvant letrozole was made available either immediately postoperative, after 2-3 years of tamoxifen, or extended 5 tamoxifen. Between October 2003 and 2005, we analyzed the subjective tolerance in 185 postoperative cancer receiving outside clinical trial. The most prominent toxicity musculoskeletal pain. In addition hot...
Background: Brain metastases form a challenge in breast cancer patients, especially HER2+ patients whose peripheral can often be controlled using standard-of-care HER2 regimens, but with relapse or progression the brain. This determines survival for such patients. Penetration brain lesions as well therapeutic outcome hampered due to particular tumour microenvironment. The here used anti-HER2 agent is single-domain antibody nanobody that targets nanomolar affinity size ten-fold smaller than...
Cancer-related cognitive impairment (CRCI) is a prevalent source of comprised quality life in cancer survivors. This study evaluated the efficacy Emotional Freedom Techniques (EFT) on self-reported CRCI (sr-CRCI).
Purpose/Objectives: To evaluate the effects of a rehabilitation program on quality life, fatigue, fear movement (kinesiophobia), distress, anxiety, depression, and physical condition.
Abstract Lessons Learned Cabazitaxel has activity in squamous cell carcinoma of the head and neck (SCCHN) taxane-resistant lines. For first time, cabazitaxel was investigated incurable patients with recurrent SCCHN. Patients were randomly assigned to every 3 weeks or weekly methotrexate. This phase II study did not meet its primary endpoint. low The toxicity profile this population also favorable owing high rate febrile neutropenia observed (17%). Background. is a second-generation taxane...