A5052822983- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Connexins and lens biology
- Proteoglycans and glycosaminoglycans research
- Adolescent Sexual and Reproductive Health
- Axon Guidance and Neuronal Signaling
Italian Institute of Technology
2020-2024
University of Genoa
2011-2024
Abstract Retinal dystrophies such as Retinitis pigmentosa are among the most prevalent causes of inherited legal blindness, for which treatments in demand. prostheses have been developed to stimulate inner retinal network that, initially spared by degeneration, deteriorates late stages disease. We recently reported that conjugated polymer nanoparticles persistently rescue visual activities after a single subretinal injection Royal College Surgeons rat model . Here we demonstrate can...
Visual cortical plasticity is high during early life, but gradually decreases with development. This due to the Otx2-driven maturation of intracortical inhibition that parallels condensation extracellular matrix components into perineuronal nets mainly around parvalbumin-positive GABAergic neurons. Repressor Element 1 Silencing Transcription (REST) epigenetically controls expression a plethora neuron-specific genes. We demonstrate conditional knockout REST in primary visual cortex adult mice...
Although mother-to-child transmission (MTCT) rates are at an all-time low in Western Europe, potentially preventable transmissions continue to occur. Duration of antenatal combination antiretroviral therapy (ART) is strongly associated with MTCT risk.Data on pregnant HIV-infected women enrolled the and Central European sites Collaborative Study between January 2000 July 2009 were analysed. The proportion receiving no ART or 1-13 days treatment was investigated, factors explored using...