A5038387722- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Saffron Plant Research Studies
- Visual perception and processing mechanisms
- Glaucoma and retinal disorders
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Retinal Diseases and Treatments
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- Neurological Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Retinopathy of Prematurity Studies
- Retinal Imaging and Analysis
- Ocular and Laser Science Research
- Connexins and lens biology
- Conducting polymers and applications
- Biochemical effects in animals
- Retinal and Optic Conditions
- Laser Applications in Dentistry and Medicine
- Morphological variations and asymmetry
- Neurological Disorders and Treatments
- Retinal and Macular Surgery
- Circadian rhythm and melatonin
- Optical Imaging and Spectroscopy Techniques
Istituto Nazionale Biostrutture e Biosistemi
2012-2025
Institute of Biostructure and Bioimaging
2023
University of L'Aquila
2013-2022
Italian Institute of Technology
2018-2022
Howard University
2019
University of Bologna
2019
Australian National University
2012-2016
Vision Cooperative Research Centre
2014
Australian Research Council
2010
Instituto di Biofisica
1987-1999
Exposure of simple cells the cat striate cortex to high-contrast drifting gratings greatly reduces subsequent response low-contrast gratings. This adaptation effect has an average duration 30 seconds and shows interocular transfer selectivity for spatial frequency orientation. is strikingly similar perceptual
Purpose.: To evaluate the functional effect of short-term supplementation saffron, a spice containing antioxidant carotenoids crocin and crocetin, in early age-related macular degeneration (AMD). Methods.: Twenty-five patients with AMD were randomly assigned to oral saffron 20 mg/d or placebo over 3-month period then reverted for further 3 months. Focal electroretinograms (fERGs) clinical findings recorded at baseline after months supplementation. fERGs response sinusoidally modulated (41...
1. The contrast sensitivity of the cat as a function spatial frequency visual stimulus was determined by using behavioural techniques. 2. No statistically significant difference found for thresholds at various orientations stimulus. 3. A comparison curve with that human shows two species have rather different characteristics resolution.
Significance Retinal degenerative diseases affect specific regions of the retinal pigment epithelium (RPE), suggesting presence functionally different RPE subpopulations. To identify these subpopulations in human eyes, we generated first complete morphometric map at single-cell resolution using artificial intelligence–based software. We identified five concentric subpopulations, including a ring cells with cell area similar to macula periphery eye. Moreover, found that are differentially...
Abstract Retinal dystrophies such as Retinitis pigmentosa are among the most prevalent causes of inherited legal blindness, for which treatments in demand. prostheses have been developed to stimulate inner retinal network that, initially spared by degeneration, deteriorates late stages disease. We recently reported that conjugated polymer nanoparticles persistently rescue visual activities after a single subretinal injection Royal College Surgeons rat model . Here we demonstrate can...
purpose. To test whether the saffron extract (Crocus sativus L.) given as a dietary supplement counteracts effects of continuous light exposure in albino rat retina. methods. Three experimental groups Sprague–Dawley rats were used. Experimental animals prefed either or β-carotene (1 mg extract/kg/d) before they exposed to bright (BCL) for 24 hours. Flash electroretinograms (fERGs) recorded control and treated day 1 week after exposure. At end second recording session, killed retinas quickly...
Objectives . In a previous randomized clinical trial (Falsini et al. (2010)), it was shown that short-term Saffron supplementation improves retinal flicker sensitivity in early age-related macular degeneration (AMD). The aim of this study to evaluate whether the observed functional benefits from may extend over longer follow-up duration. Design Longitudinal, interventional open-label study. Setting Outpatient ophthalmology setting. Participants Twenty-nine AMD patients (age range: 55–85...
Replacement strategies arise as promising approaches in case of inherited retinal dystrophies leading to blindness. A fully organic prosthesis made conjugated polymers layered onto a silk fibroin substrate is engineered. First, the biophysical and surface properties are characterized; then, long-term biocompatibility assessed after implantation device subretinal space 3-months-old rats for period five months. The results indicate good stability implants over time, with preservation physical...
The first target of any therapy for retinal neurodegeneration is to slow down the progression disease and maintain visual function. Cerium oxide or ceria nanoparticles reduce oxidative stress, which known play a pivotal role in neurodegeneration. Our aim was investigate whether cerium were able mitigate including microglial activation related inflammatory processes induced by exposure high intensity light. injected intravitreally intraveinously albino Sprague-Dawley rats three weeks before...
To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and maculopathy susceptibility 2 (ARMS2) risk genotypes. Thirty-three AMD patients, screened for CFH (rs1061170) ARMS2 (rs10490924) polymorphisms receiving Saffron (20 mg/day) over an average period treatment 11 months (range, 6–12), were longitudinally evaluated clinical...
Crocus sativus L. belongs to the Iridaceae family and it is commonly known as saffron. The different cultures together with geoclimatic characteristics of territory determine a chemical composition that characterizes final product. This why complete knowledge this product fundamental, from which more than 150 compounds have been extracted from, but only about one third them identified. saffron has studied in relation its efficacy coping neurodegenerative retinal diseases. Accordingly,...
Wang, Guo-Yong, G.-M. Ratto, Silvia Bisti, and Leo M. Chalupa. Functional development of intrinsic properties in ganglion cells the mammalian retina. J. Neurophysiol. 78: 2895–2903, 1997. Sensory neurons manifest pronounced changes excitability during maturation, but factors contributing to this ubiquitous developmental phenomenon are not well understood. To assess contribution membrane such excitability, present study whole cell patch-clamp recordings were made from developing intact retina...
The spatial and temporal response properties of neurones areas 17 18 were studied in single units (165) anaesthetized paralysed cats. visual stimuli drifting or alternating gratings. We confirmed extended the observation by Tolhurst & Movshon (1975) showing that spatial‐frequency characteristics area are largely independent parameters tuning curves shift along axis when velocity frequency grating changed. effect an increase either is to cell curve down scale, keeping relatively constant...
Experimental studies demonstrated that saffron (Crocus sativus) given as a dietary supplement counteracts the effects of bright continuous light (BCL) exposure in albino rat retina, preserving both morphology and function probably acting regulator programmed cell death [1]. The purpose this study was to ascertain whether neuroprotective effect on retina exposed BCL is associated with modulation endocannabinoid system (ECS). To aim, we used eight experimental groups Sprague-Dawley rats, which...