A5016571029- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Medical Imaging and Pathology Studies
- Parathyroid Disorders and Treatments
- Coronary Interventions and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Acute Myocardial Infarction Research
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Advanced X-ray and CT Imaging
- Pericarditis and Cardiac Tamponade
- Cardiac and Coronary Surgery Techniques
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
Fondazione Toscana Gabriele Monasterio
2016-2025
Regione Toscana
2015-2024
University College London
2024
University of Iowa Hospitals and Clinics
2023
University of Pisa
1995-2021
Azienda Ospedaliera Universitaria Pisana
2016-2021
Scuola Superiore Sant'Anna
2018
University of Leeds
2016
Christie's
2016
Creative Commons
2016
Background — Depressed myocardial blood flow (MBF) has been reported in dilated cardiomyopathy. The aim of this study was to investigate whether MBF impairment is an independent predictor prognosis patients with idiopathic left ventricular (LV) dysfunction. Methods and Results Sixty-seven (52 male, mean age 52±12 years) different degrees LV systolic dysfunction (average ejection fraction, 0.34±0.10; range, 0.07 0.49) were prospectively enrolled. Thirty-four subjects (51%) had no history...
Background Myocardial blood flow (MBF) impairment has been documented in advanced dilated cardiomyopathy (DCM) which hemodynamic factors, secondary to severe ventricular dysfunction, may limit myocardial perfusion. To assess whether MBF DCM also be present independent of the study was designed quantify perfusion patients with mild disease without overt heart failure. Methods and Results Absolute regional (milliliters per minute gram) measured by positron emission tomography 13 N-ammonia...
Background The relative contribution of amyloid and fibrosis to extracellular volume expansion in cardiac amyloidosis (CA) has never been defined. Methods Results We included all patients diagnosed with light-chain (AL) or transthyretin at a tertiary referral center between 2014 2020 undergoing left ventricular endomyocardial biopsy. Patients (n=37) were more often men (92%), median age 72 years (interquartile range, 68-81). Lambda-positive AL was found 14 19 cases (38%) kappa-positive 5...
Abstract Aims Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) affects older adults and is currently considered as a rare disorder. We investigated for the first time prevalence of ATTRwt-CA in elderly individuals from general population. Methods results General practitioners Pisa, Italy, proposed screening to all their patients aged 65–90 years, until 1000 accepted. The following red flags were searched: interventricular septal thickness ≥ 12 mm, any echocardiographic,...
A novel technology has been developed for ultrafast (UF) single-photon emission CT (SPECT) myocardial perfusion imaging by using a pinhole collimation design and multiple cadmium zinc telluride crystal arrays. The purpose of this study was to compare obtained UF-SPECT with standard (S) SPECT in patients known or suspected coronary artery disease.A total 34 underwent single-day (99m)Tc-tetrofosmin stress/rest imaging. performed 10 minutes before S-SPECT. Images were qualitatively analyzed,...
AimsTo investigate the relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function obtained by means of a low-dose imaging protocol with cadmium–zinc–telluride (CZT) dedicated camera.
The aim of this study was to compare the results dipyridamole-echocardiography test (DET: two-dimensional echo monitoring during dipyridamole infusion up 0.84 mg/kg over a period 10 minutes) with both anatomic and physiological parameters coronary artery disease severity, assessed by computer-assisted quantitative arteriography, regional flow reserve, measured [13N]ammonia (13NH3) dynamic positron emission tomography (PET), respectively.We studied 31 patients history chest pain neither...
BACKGROUND Recent evidence suggests that, in coronary artery disease (CAD), myocardial blood flow (MBF) regulation is abnormal regions supplied by apparently normal arteries. However, the relation between this alteration and MBF response to increasing metabolic demand has not been fully elucidated. METHODS AND RESULTS was assessed at baseline, during atrial pacing tachycardia, after dipyridamole (0.56 mg/kg IV over 4 minutes) 9 subjects 24 patients with ischemia on effort, no infarction,...
Background The comparative effects of calcium channel blockers and ACE inhibitors on myocardial blood flow (MBF) in hypertensive patients after long-term treatment are still unknown. Methods Results Twenty subjects with normal coronary arteries were randomly assigned to verapamil 240 480 mg/d or enalapril 10 40 mg/d. MBF was quantified at rest, during pacing tachycardia, dipyridamole by positron emission tomography 13 N-ammonia before 6 months 1 week pharmacological washout. In both groups,...
The aim of this study was to investigate whether early (time 1, or T1) myocardial tetrofosmin imaging is feasible and as accurate in detecting coronary artery disease standard delayed 2, T2) imaging. <b>Methods:</b> One hundred twenty patients (100 men 20 women; mean age ± SD, 61 10 y) with anginal symptoms underwent gated SPECT. Stress/rest T1 performed at 15 min T2 45 after injection. Image quality visually evaluated using a 4-point scale (from 0 = poor 3 optimal). Myocardial perfusion...