A5005417269- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Ultrasound in Clinical Applications
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Cancer Treatment and Pharmacology
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Hemodynamic Monitoring and Therapy
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Blood Pressure and Hypertension Studies
Fondazione Toscana Gabriele Monasterio
2020-2025
Scuola Superiore Sant'Anna
2021-2025
Ospedale Versilia
2025
University College London
2024
University of Brescia
2023
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2023
Maria Cecilia Hospital
2023
University of Messina
2023
University of Florence
2023
University of Ferrara
2023
Cardiotoxicity is a relevant complication that may compromise the clinical use of anthracyclines, affecting quality life and overall survival in cancer patients, independently oncological prognosis. The paper provides an overview anthracycline-induced cardiotoxicity terms definition, classification, incidence, risk factors, possible mechanisms, diagnosis, treatment. We also reported effective strategies for preventing cardiotoxicity. Furthermore, we discussed limitation current approaches,...
Cardiac amyloidosis (CA) affects the four heart chambers, which can all be evaluated through speckle-tracking echocardiography (STE).We 423 consecutive patients screened for CA over 5 years at two referral centres. was diagnosed in 261 (62%) with either amyloid transthyretin (ATTR; n = 144, 34%) or light-chain (AL; 117, 28%) CA. Strain parameters of chambers were altered patients, particularly those ATTR-CA. Nonetheless, only peak left atrial longitudinal strain (LA-PALS) displayed an...
Abstract Aims Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) affects older adults and is currently considered as a rare disorder. We investigated for the first time prevalence of ATTRwt-CA in elderly individuals from general population. Methods results General practitioners Pisa, Italy, proposed screening to all their patients aged 65–90 years, until 1000 accepted. The following red flags were searched: interventricular septal thickness ≥ 12 mm, any echocardiographic,...
Risk stratification of heart failure (HF) patients with preserved ejection fraction (HFpEF) can promote a more personalized treatment. We tested the prognostic value multi-parametric evaluation, including biomarkers, cardiopulmonary exercise testing-exercise stress echocardiography (CPET-ESE), and lung ultrasound, in HFpEF subjects at risk developing HF (HF Stages A B).Risk treatment.We B).We performed resting clinical/bio-humoural evaluation symptom-limited CPET-ESE 274 (45 Stage A, 68 B,...
To characterize heart failure (HF) with mid-range ejection fraction (HFmrEF), combining cardiopulmonary exercise test, and stress echocardiography. We studied 169 consecutive subjects (age 62.3 ± 11 years; 74% male): 30 healthy controls, 45 patients HF preserved EF (HFpEF), 40 HFmrEF, 54 reduced (HFrEF). Left ventricular (LV) stroke volume (SV), EF, elastance, global longitudinal strain, E/E', oxygen consumption (VO2), arterial-venous content difference (AVO2diff) were measured in all...
Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which more reproducible, feasible, less time consuming. In 26 expert centers, LA analyzed echocardiographers (young vs senior) in a blinded fashion. population included: healthy subjects, patients arterial hypertension or aortic stenosis (LA...
Type 2 diabetes mellitus (T2D) increases the risk of incident heart failure (HF), whose earliest fingerprint is effort intolerance (i.e. impaired peak oxygen consumption, or VO2peak). In uncomplicated T2D population, however, prevalence and underpinning mechanistic bases are uncertain. Leveraging multiparametric characterization allowed by imaging-cardiopulmonary exercise testing (iCPET), aim this study to quantify in dissect associated cardiopulmonary alterations.Eighty-eight adults with...
Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular death and risk factors, aside from lowering plasma glucose levels. With this study we aim at determining whether treatment with empagliflozin associated an improvement LV functions diabetic patients asymptomatic against Sitagliptin, which presumably neutral on myocardial function. To...
Myocardial fibrosis (MF) is a deleterious consequence of aortic valve stenosis (AVS). Global longitudinal strain (GLS) novel left ventricular (LV) functional parameter potentially useful to non-invasively estimate MF. MicroRNAs (miRNAs) are non-coding small ribonucleic acids (RNA) modulating genes function, mainly through RNA degradation. miRNA-21 biomarker associated with MF in pressure overload. The aim the present study was find an integrated algorithm for detection using combined...
Peak cardiac power output-to-mass (CPOM) represents a measure of the rate at which work is delivered respect to potential energy stored in left ventricular (LV) mass. We studied value CPOM and cardiopulmonary exercise test (CPET) risk stratification patients with heart failure (HF).We 159 chronic HF (mean rest LV ejection fraction 30%) undergoing CPET stress echocardiography. was calculated as product constant (K = 2.22 × 10-1) output (CO) mean blood pressure (MBP), divided by mass (M),...
Aims Chronic kidney dysfunction (CKD) and persistent congestion influence heart failure prognosis, but little is known about the role of inflammation in this association. We assessed relationship between inflammatory biomarkers, CKD their prognostic implications patients with acute failure. Methods enrolled 97 hospitalised (mean age: 66 ± 12 years, ejection fraction: 30 8%) Before discharge, was using a scoring system on basis Framingham criteria. Circulating levels high-sensitivity...
The mechanism through which sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent the incidence of heart failure and/or affect cardiac structure and function remains unclear.The EMPA-HEART trial is aimed at verifying whether empagliflozin improves myocardial contractility (left ventricle global longitudinal strain, LV-GLS) cardiopulmonary fitness (peak oxygen uptake, VO2peak) in subjects with type diabetes (T2D) without disease. Patients T2D, normal LV systolic (2D-Echo EF > 50%), no...
Abstract Background An echocardiographic algorithm to estimate pulmonary capillary wedge pressure (ePCWP) and vascular resistance (ePVR) has been recently validated versus right heart catheterization (1). Purpose The aim of this study was assess the prognostic significance these measures in failure (HF) patients. Methods Consecutive outpatients with HF left ventricular ejection fraction (LVEF) <50% undergoing echocardiography were selected followed-up for composite endpoint cardiac...