A5029830455- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Gastroesophageal reflux and treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Genetic factors in colorectal cancer
- Aortic aneurysm repair treatments
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Advanced biosensing and bioanalysis techniques
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- Cerebrovascular and Carotid Artery Diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Multiple Sclerosis Research Studies
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Cardiac pacing and defibrillation studies
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2020-2025
University of Salerno
2024
Leonardo (United Kingdom)
2024
Oryzon Genomics (Spain)
2023-2024
University of Naples Federico II
1993-2021
University of Campania "Luigi Vanvitelli"
2020-2021
University of Palermo
2020
Sapienza University of Rome
2004-2020
United States Congress
2020
Academic Center for Dentistry Amsterdam
2020
Cancer-associated fibroblasts (CAFs) are the major components of tumor microenvironment. They may drive progression, although mechanisms involved still poorly understood. Exosomes have emerged as important mediators intercellular communication in cancer. mediate horizontal transfer microRNAs (miRs), mRNAs and proteins, thus affecting breast cancer progression. Differential expression profile analysis identified three miRs (miRs -21, -378e, -143) increased exosomes from CAFs compared normal...
The aim of this study was to evaluate factors associated with pathologic tumor response following pre-operative chemoradiation therapy, and the prognostic impact on overall disease-free survival.Between 1994 2002, 132 patients underwent therapy followed by surgery for middle lower rectal cancer. After excluding 26 cases (metastatic cancer, n = 13; nonradical surgery, 6; local excision procedure, 4; non-5-fluorouracil-based chemotherapy, 2; incomplete data preoperative regimen used, 1),...
Breast cancer remains one of the leading causes mortality among women. It has been proved that onset depends on a very small pool tumor cells with phenotype similar to normal adult stem cells. Cancer (CSC) possess self-renewal and multilineage differentiation potential as well robust ability sustain tumorigenesis. Evidence suggests CSCs contribute chemotherapy resistance survival under hypoxic conditions. Interestingly, hypoxia in turn regulates these effects may be primarily mediated by...
TNF-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent for its remarkable ability to selectively induce apoptosis in cancer cells, without affecting the viability of healthy bystander cells. The TRAIL tumor suppressor pathway deregulated many human malignancies including lung cancer. In non-small cell (NSCLC) sensitization therapy can be restored by increasing expression levels microRNA-212 (miR-212) leading inhibition anti-apoptotic protein PED/PEA-15 implicated...
Oxidation effects on SERS response of Ag nanoprism arrays are interpreted by FEM simulations the local-field distribution around nanoprisms.
The importance of transient ischemic attack (TIA) lies on the short-term risk stroke, and ABCD2 score may improve early stroke prediction. However, population-based studies are still needed. We aimed to provide data TIA incidence evaluate predictive ability for recurrent in a study.This study is part 2-year prospective community-based registry all cerebrovascular events district Udine (153 312 inhabitants), Friuli Venezia Giulia region, northeast Italy, between April 1, 2007 March 31, 2009....
Purpose Lymph node (LN) involvement is the most important prognostic factor in colorectal cancer (CRC), and pN-positive status identifies patients who require adjuvant chemotherapy. Approximately 15% to 20% of without nodal metastases (pN0) develop recurrent disease. In this study, we tested significance isolated tumor cells (ITCs) LNs with pN0 CRC (stages I II). Patients Methods ITCs regional were assessed 312 consecutive followed up clinically and/or endoscopically for at least 6 months...
BACKGROUND In the general population, Helicobacter pylori (H. pylori), particularly cagA positive strain, has been associated with intestinal-type gastric carcinoma. Gastric carcinomas are rarely observed in patients age ≤40 years. Host-related factors have thought to be more important than environmental agents these early-onset cancers. The aim of this study was ascertain possible role H. infection and that strains development carcinoma young patients. METHODS case−control study, 105...
Oxidative DNA damage is associated with Helicobacter pylori infection, atrophy and intestinal metaplasia. H. pylori-cagA-positive strains are the highest risk of gastric cancer.To ascertain whether cagA-positive infection correlates higher concentrations 8OHdG presence precancerous changes.118 patients were studied (65M/53F, age 61 +/- 14 years). Twelve pylori-negative. Among pylori-positive patients, 34 40 cagA negative. In 32 had been eradicated at least 6 months before endoscopic...
// Danilo Fiore 1 , Elvira Donnarumma 2 Giuseppina Roscigno 1, 3 Margherita Iaboni Valentina Russo Alessandra Affinito Assunta Adamo Fabio De Martino Cristina Quintavalle 4 Giulia Romano 5 Adelaide Greco 6, 7 Ylermi Soini 8 Arturo Brunetti Carlo M. Croce Gerolama Condorelli Department of Molecular Medicine and Medical Biotechnology, "Federico II" University Naples, Italy IRCCS-SDN, IEOS, CNR, Institute Pathology, Pathology Division, Basel, Switzerland Virology, Immunology Genetics, Human...
Geographical differences have been shown in the clinical outcomes of Helicobacter pylori—associated gastritis phenotypes and gastric cancer risk. This study tested whether Operative Link on Gastritis Assessment (OLGA) staging correlated with risk populations from 3 continents. Mapped biopsies were obtained 316 dyspeptic adults aged less than 41 years 8 geographic areas that differed Gastric atrophy was assessed according to internationally validated criteria. stage established OLGA system....
Background Stroke incidence in high-income countries is reported to decrease, and new data on stroke outcome are needed design services ameliorate management. Methods This study part of a two-year prospective community-based registry all cerebrovascular events the district Udine (153 312 inhabitants), Friuli-Venezia Giulia region, northeast Italy, between 1 April 2007 31 March 2009. Overlapping sources for case finding were used, combining hot cold pursuit. Results We identified 784 cases,...
Abstract Background Cardiac remodeling in athletes involve both the left and right ventricular atrial chambers is considered to be a physiological adaptation high, repeated hemodynamic load induced by regular exercise training. Notably, endurance training leads greatest increase of cardiac chamber diameters volumes, often mimicking pathologic conditions. In this setting, studies on aortic are more limited restricted small athlete’s cohorts. Purpose To assess presence extent an "aortic...
Nanosphere lithography coupled with reactive ion etching has been used to synthesize hexagonal ordered arrays of Au-Ag bimetallic semi-nanoshells be as plasmonic biosensors. The degree lateral interaction between adjacent can controlled by tailoring the time in order boost global properties through formation near-field hot-spots, which turn improve sensitivity To test efficiency proposed system a biosensor, we an established protocol for detection biomolecules (local sensitivity), based on...
Atrophic gastritis is a precancerous condition that commonly caused by chronic Helicobacter pylori (H. pylori) infection. This blinded, controlled study was designed to determine if serum gastrin and pepsinogens were reliable markers of atrophy in asymptomatic patients.One hundred forty-seven patients underwent endoscopy with multiple gastric biopsies obtained for histology, culture, rapid urease test. Fasting (total G-17) (I-II) determined standard immunoassays. Gastric histologically...
The effect of topical ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes was evaluated. study performed 10 healthy volunteers glaucomatous patients. Systolic arterial blood (SBP), diastolic (DBP), heart rate (HR), IOP, tonographic outflow facility, pupil diameter, corneal thickness, tear secretion were recorded at baseline 1 hour intervals for 12 hours after administration 0.5% or placebo, given a randomised, double masked, crossover fashion. alternative treatment...
Restless legs syndrome (RLS) is a sensorimotor disorder. It can be idiopathic, associated to other diseases or pharmacologic treatments. RLS has been reported occur more frequently in migraine patients, but clear pathogenetic link seems still under debate. We aimed evaluate prevalence migraine, impact on sleep quality and the main clinical determinants of this association.Migraine patients age- sex-matched controls were enrolled from 1st January 2011 30th December 2012. Migraine diagnosis...