Matteo Mazzola
A5080531332- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Cardiovascular Disease and Adiposity
- Ultrasound in Clinical Applications
- Heart Failure Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- HIV-related health complications and treatments
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Ultrasound and Hyperthermia Applications
- Venous Thromboembolism Diagnosis and Management
- Eosinophilic Disorders and Syndromes
- Photonic Crystals and Applications
- Sarcoidosis and Beryllium Toxicity Research
- Acute Myocardial Infarction Research
- Cardiovascular Issues in Pregnancy
- Systemic Sclerosis and Related Diseases
- Corporate Taxation and Avoidance
Azienda Ospedaliera Universitaria Pisana
2020-2025
University of Pisa
2019-2024
October 6 University
2022
Centre National de la Recherche Scientifique
2022
Université de Technologie de Troyes
2022
Istituto di Fisiologia Clinica
2020-2021
National Research Council
2021
Risk stratification of heart failure (HF) patients with preserved ejection fraction (HFpEF) can promote a more personalized treatment. We tested the prognostic value multi-parametric evaluation, including biomarkers, cardiopulmonary exercise testing-exercise stress echocardiography (CPET-ESE), and lung ultrasound, in HFpEF subjects at risk developing HF (HF Stages A B).Risk treatment.We B).We performed resting clinical/bio-humoural evaluation symptom-limited CPET-ESE 274 (45 Stage A, 68 B,...
Type 2 diabetes mellitus (T2D) increases the risk of incident heart failure (HF), whose earliest fingerprint is effort intolerance (i.e. impaired peak oxygen consumption, or VO2peak). In uncomplicated T2D population, however, prevalence and underpinning mechanistic bases are uncertain. Leveraging multiparametric characterization allowed by imaging-cardiopulmonary exercise testing (iCPET), aim this study to quantify in dissect associated cardiopulmonary alterations.Eighty-eight adults with...
Lung ultrasound B-lines are the sonographic sign of pulmonary congestion and can be used in differential diagnosis dyspnoea to rule or out acute heart failure (AHF). Our aim was assess prognostic value B-lines, integrated with echocardiography, patients admitted a cardiology department, independently initial clinical presentation, thus without AHF, AHF reduced preserved ejection fraction (HFrEF HFpEF).
Abstract Tricuspid regurgitation (TR) carries an unfavourable prognosis and often leads to progressive right ventricular (RV) failure. Secondary TR accounts for over 90% of cases is caused by RV and/or tricuspid annulus dilation, in the setting left heart disease or pulmonary hypertension. Surgical treatment isolated entails a high operative risk seldom performed. Recently, transcatheter edge-to-edge repair (TEER) has emerged as low-risk alternative selected patients. Although experience...
Right ventricular impairment is common among patients undergoing transcatheter edge-to-edge repair for secondary mitral regurgitation (SMR). Adherence to guideline-directed medical therapy (GDMT) heart failure poor in these patients. The aim of this study was evaluate the impact GDMT on long-term survival patient cohort. Within EuroSMR (European Registry Transcatheter Repair Secondary Mitral Regurgitation) international registry, we selected with SMR and right (tricuspid annular plane...
We investigated the role of dynamic changes pulmonary congestion, as assessed by sonographic B-lines, a tool to stratify prognosis in patients admitted for acute heart failure with reduced and preserved ejection fraction (HFrEF, HFpEF). In this multicenter, prospective study, lung ultrasound was performed at admission before discharge trained investigators, blinded clinical findings. enrolled 208 consecutive (mean age 76 [95% confidence interval, 70-84] years), 125 HFrEF, 83 HFpEF 32% 57%,...
Abstract Purpose This study was a quality-control of resting and exercise Doppler echocardiography (EDE) variables measured by 19 laboratories with proven experience participating in the RIGHT Heart International NETwork. Methods All investigators reported requested from ten randomly selected stress tests. Intraclass correlation coefficients (ICC) were calculated to evaluate inter-observer agreement core laboratory. Inter-observer variability peak tricuspid regurgitation velocity (TRV),...
Purpose: To evaluate the potential confounding effect of concomitant pneumonia (PNM) on lung ultrasound (LUS) B-lines in acute heart failure (AHF). Methods: We enrolled 86 AHF patients with (31 pts, AHF/PNM) and without (55 AHF) PNM. LUS were evaluated using a combined antero-lateral (AL) posterior (POST) approach at admission (T0), after 24 h from T0 (T1), 48 (T2) before discharge (T3). score was calculated each time point AL POST chest, dividing number by explorable scanning sites. The...
Sacubitril/valsartan, an angiotensin receptor neprilysin inhibitor, was shown to improve outcome in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). There are reasons for believing that the concept lower B-type natriuretic peptide (BNP) circulating level better prognosis may no longer be correct treated sacubitril/valsartan, since sacubitril interfere BNP clearance. We reported a case series of ten stable chronic HF LVEF ≤35% (mean age: 64 ± 8 years;...
Mitral stenosis results from haemodynamic obstruction at the mitral valve level because of structural abnormalities apparatus, leading to increased resistance transmitral flow. Although rheumatic fever remains predominant cause worldwide, other causes are increasingly relevant in developed countries with degenerative (DMS) annulus calcification (MAC) becoming growingly prevalent industrialized higher life expectancy. Rheumatic (RMS) and DMS display dramatic differences pathophysiology,...