A5058775568- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Protein Degradation and Inhibitors
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Multiple Sclerosis Research Studies
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Bone and Joint Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Hematological disorders and diagnostics
- Cytomegalovirus and herpesvirus research
- Acute Lymphoblastic Leukemia research
- COVID-19 Impact on Reproduction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Long-Term Effects of COVID-19
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2015-2025
University of Brescia
2023
Center for Research in Environmental Epidemiology
2020
Centro de Recursos Educativos Avanzados
2020
Abstract Purpose: Early intervention in smoldering multiple myeloma (SMM) requires optimal risk stratification to avoid under- and overtreatment. We hypothesized that replacing bone marrow (BM) plasma cells (PC) for circulating tumor (CTC), adding immune biomarkers peripheral blood (PB) the identification of patients at progression due lost surveillance, could improve International Myeloma Working Group 20/2/20 model. Experimental Design: report outcomes 150 with SMM enrolled iMMunocell...
Diffusion-weighted whole-body MRI (DW-MRI) is increasingly used in the management of multiple myeloma (MM) patients, but data regarding prognostic role DW-MRI imaging response after treatment are lacking. The Myeloma Response Assessment and Diagnosis System (MY-RADS) recommendations recently proposed criteria for assessment category (RAC) with a 5-point scale order to standardize therapy, this score still needs be validated.We investigated RAC 64 newly diagnosed MM patients autologous stem...
Functional high-risk (FHR) multiple myeloma (MM) patients, defined as those with early relapse despite optimal initial therapy, represent an unmet clinical need. Diffusionweighted whole-body MRI (DW-MRI) is increasingly used in MM management due to its high sensitivity assessing treatment response. The Myeloma Response Assessment and Diagnosis System (MY-RADS) established the Category (RAC), a 5-point scale ranging from complete response (RAC 1) progressive disease 5), which independently...
Multiple Myeloma (MM) is a hematological malignancy caused by microenviromentally-aided persistence of plasma cells in the bone marrow. Monoclonal often secrete high amounts immunoglobulin free light chains (FLCs) that could induce tissue damage. Recently we showed FLCs are internalized endothelial and myocardial cell lines secreted extracellular vesicles (EVs). MM serum derived EVs presented phenotypic differences if compared with gammophaty undetermined significance (MGUS) suggesting their...
Abstract Risk stratification in acute myeloid leukemia ( AML ) patients using prognostic parameters at diagnosis is effective, but may be significantly improved by the use of on treatment which better define actual sensitivity to therapy single patient. Minimal residual disease MRD monitoring has been demonstrated crucial for identification high risk relapse, best method and timing detection are still discussed. Thus, we retrospectively analyzed 104 newly diagnosed patients, consecutively...
Colorectal carcinoma (CRC) represents a lethal disease with heterogeneous outcomes. Only patients mismatch repair (MMR) deficient CRC showing microsatellite instability and hyper-mutated tumors can obtain clinical benefits from current immune checkpoint blockades; on the other hand, immune- or target-based therapeutic strategies are very limited for subjects proficient (CRCpMMR). Here, we report comprehensive typing of infiltrating cells in CRCpMMR. We also tested expression...
T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) relapse of hematological malignancies after stem cell transplantation (SCT). Their sequential assessment together with neogenesis indexes has thoroughly analysed in relation these changing interrelated immunologic/clinic events yet. Lymphocyte peripheral blood (PB) were at different time points a prospective study 50 patients. Principal component analysis (PCA) was used as first step...
Multiple Myeloma (MM) is still considered an incurable disease. However, the availability of novel and effective therapies making prospect eradicating malignant clone converting MM into a curable disease realistic. In this context, detection minimal residual (MRD) has become utmost importance. The high spatial genomic heterogeneity that characterizes patients explains potential persistence even in bone marrow (BM) MRD negative patients, highlighting need different techniques able to detect...
CRCMSS/pMMR contain a significantly increased fraction of TREM2+ macrophages (TAMs) and CD66+ neutrophils (TANs) together with decrease CD4-CD8-CD3+ double negative T lymphocytes (DNTs); no differences were revealed by the analysis myeloid plasmacytoid dendritic cell populations. A tumor-infiltrating T-cells display an exhausted phenotype, co-expressing PD-1 TIM-3. Remarkably, expression PD-L1 on fresh tumor cells TAMs was undetectable even after in vitro stimulation interferon-γ. These...
Abstract Combination of anti-retroviral therapy, high-dose chemotherapy (HCT) and autologous stem cell transplantation (ASCT) has led to an improved survival HIV + non-Hodgkin lymphoma (NHL) patients. We compared T- B-cell subset recovery related capability respond in-vitro stimulation, as well T-cell repertoire modifications − NHL patients undergoing HCT ASCT first-line consolidation or salvage treatment, using sequential blood samples obtained before at 3, 6, 12 24 months after ASCT. B...
The mechanisms underlying the therapeutic activity of interferon-β in multiple sclerosis are still not completely understood. In present study, we evaluated short and long-term effects treatment on different subsets regulatory T cells relapsing-remitting patients biologically responsive to because mixovirus resistance protein A inducibility.In this prospective longitudinal natural (naïve, central memory effector memory) inducible (Tr1), as well vitro-induced (Tr1-like cells), were...
Levels of Kappa-deleting recombination excision circles (KRECs), T-cell receptor (TRECs), and repertoire diversity were evaluated in 1038 samples 124 children with primary immunodeficiency, whom 102 (54 severe combined immunodeficiency 48 other types immunodeficiency) underwent hematopoietic stem cell transplantation. Twenty-two not transplanted patients used as controls. Only data from at least five sent to the clinical laboratory for routine monitoring lymphocyte reconstitutions included...